个人简历

毕洪凯，南京医科大学基础医学院教授，博士生导师。2017年入选江苏特聘教授，2018年入选江苏特聘医学专家和双创团队核心成员。2009年获得日本国立千叶大学医药学博士学位，2019-2015年在美国伊利诺伊大学厄本那-香槟分校做博士后研究员工作。目前担任中国药理学会海洋药物药理专委会委员，江苏省药学会海洋药物专委会委员和国家自然科学基金通讯评审专家等。现主持国家自然科学基金面上项目2项、国家重点研发计划课题1项和江苏省高等学校自然科学研究重大项目1项，近年来发表SCI论文20余篇，申请发明专利2项，获得中华医学科技进步奖三等奖一次。

研究领域

研究方向：
1.新型抗菌药物筛选与研发
2.幽门螺杆菌致病新机理
3.抗菌药物新靶点确证

近期论文

近年来发表代表作论文：
1.JiangX,DuanY,ZhouB,GuoQ,WangH,HangX,ZengL,JiaJ,BiH*.TheCyclopropaneFattyAcidSynthaseMediatesAntibioticResistanceandGastricColonizationofHelicobacterpylori.JBacteriol.2019Sep20;201(20).pii:e00374-19.
2.HuangY,HangX,JiangX,ZengL,JiaJ,XieY,LiF,BiH*.InVitroandInVivoActivitiesofZincLinolenate,aSelectiveAntibacterialAgentagainstHelicobacterpylori.AntimicrobAgentsChemother.2019May24;63(6).pii:e00004-19.
3.HangX,ZengQ,ZengL,JiaJ*,BiH*.FunctionalReplacementoftheBioCandBioHProteinsofEscherichiacoliBiotinPrecursorBiosynthesisbyEhrlichiachaffeensisNovelProteins.CurrMicrobiol.2019May;76(5):626-636.
4.QiaoY,YanJ,JiaJ,XueJ,QuX,HuY,DengZ,BiH*,ZhuD*.CharacterizationoftheBiosyntheticGeneClusterfortheAntibioticArmeniaspirolsinStreptomycesarmeniacus.JNatProd.2019Feb22;82(2):318-323.
5.ShenS,HangX,ZhuangJ,ZhangL*,BiH*,ZhangL*.Aback-doorPhenylalaninecoordinatesthestepwisehexamericloadingofacylcarrierproteinbythefattyacidbiosynthesisenzymeβ-hydroxyacyl-acylcarrierproteindehydratase(FabZ).IntJBiolMacromol.2019May1;128:5-11.
6.BiH*,ZhuL,JiaJ,ZengL,CronanJE*.UnsaturatedFattyAcidSynthesisintheGastricPathogenHelicobacterpyloriProceedsviaaBacktrackingMechanism.CellChemBiol.2016Dec22;23(12):1480-1489.
7.BiH*,ZhuL,JiaJ,CronanJE*.ABiotinBiosynthesisGeneRestrictedtoHelicobacter.SciRep.2016Feb12;6:21162.
8.CaoDM,LuQF,LiSB,WangJP,ChenYL,HuangYQ*,BiHK*.ComparativeGenomicsofH.pyloriandNon-PyloriHelicobacterSpeciestoIdentifyNewRegionsAssociatedwithItsPathogenicityandAdaptability.BiomedResInt.2016;2016:6106029.
9.BiH,YuY,DongH,WangH,CronanJE*.Xanthomonascampestris RpfBisafattyAcyl-CoAligaserequiredtocounteractthethioesteraseactivityoftheRpfFdiffusiblesignalfactor(DSF)synthase.MolMicrobiol.2014Jul;93(2):262-75.
10.BiH*,ZhangC.IntegrationhostfactorisrequiredfortheinductionofacidresistanceinEscherichiacoli.CurrMicrobiol.2014Aug;69(2):218-24.
11.BiH,ZhuL,WangH,CronanJE*.InefficienttranslationrenderstheEnterococcusfaecalisfabKenoyl-acylcarrierproteinreductasephenotypicallycryptic.JBacteriol.2014Jan;196(1):170-9.
12.ZhuL#,BiH#,MaJ,HuZ,ZhangW,CronanJE*,WangH*.Thetwofunctionalenoyl-acylcarrierproteinreductasesofEnterococcusfaecalisdonotmediatetriclosanresistance.MBio.2013Oct1;4(5):e00613-13.
13.BiH,WangH,CronanJE*.FabQ,adual-functiondehydratase/isomerase,circumventsthelaststepoftheclassicalfattyacidsynthesiscycle.ChemBiol.2013Sep19;20(9):1157-67.
14.BiH,ChristensenQH,FengY,WangH,CronanJE*.TheBurkholderiacenocepaciaBDSFquorumsensingfattyacidissynthesizedbyabifunctionalcrotonasehomologuehavingbothdehydrataseandthioesteraseactivities.MolMicrobiol.2012Feb;83(4):840-55.