个人简历

【学历简介】

2004-2007年浙江理工大学生物化学与分子生物学硕士。
2007-2011年浙江大学化学博士。

【科研项目】

1.国家青年自然科学基金（Nos.31200602）

2.国家博士后二等资助（Nos.2012M521001）

3.江苏大学人才基金（Nos.1281330021）

【专利】

1.发明专利(申请号：201210384554.7)：一种改性树脂支载的过渡金属催化剂的载体制备方法，排名1/2

近期论文

1.NiZ,et.al.ACombinationofComputationalandExperimentalApproachestoInvestigatetheBindingBehaviorofB.subLipaseAMutantswithSubstratepNPP.Mol.Inform.2011,30:359-367.

2.NiZ,et.al.IntegratingInSilicoandInVitroApproachestoDissecttheStereoselectivityofBacillussubtilisLipaseAtowardsKetoprofenVinylEster.Chem.Biol.DrugDes.2011,78:301-308.

3.NiZ,et.al.InsightintosubstituenteffectsinCal-Bcatalyzedtransesterificationbycombiningexperimentalandtheoreticalapproaches.J.Mol.Model.2013,19,349-358.

4.NiZ,et.al.JustanadditionalhydrogenbondcandramaticallyreducethecatalyticactivityofB.sublipaseAI12Tmutant:anintegrationofcomputationalmodelingandexperimentalanalysis.Comput.Biol.Med.2013,43:1882-1888.

5.NiZ,et.al.Whyissubstratepeptidebindingunsusceptibletomultidrug-resistantmutationsinHIV-1protease?Astructuralandenergeticanalysis.Int.J.Pept.Res.Ther.(Inpress,DOI:10.1007/s10989-013-9365-9).

6.NiZ,et.al.InsightintomolecularmechanismunderlyingthetransesterificationcatalyzedbypenicillinGamidase(PGA)usingacombinationprotocolofexperimentalandtheoreticalanalyses.Mol.Simul.(Inpress,DOI:10.1080/08927022.2013.850500).

7.NingJH,ChenWW,LiJJ,PengZX,WangJH,NiZ*.Structuralandenergeticinsightsintosequence-specificinteractioninDNA–drugrecognition:developmentofaffinitypredictorandanalysisofbindingselectivity.JMolModel.2013,19:1573-1582.

8.JinR,MaY,QinL,NiZ*.Structure-basedpredictionofdomain-peptidebindingaffinitybydissectingresidueinteractionprofileatcomplexinterface:acasestudyonCALPDZdomain,ProteinPept.Lett.2013,20:1018-1028.

9.ChenHY,SunTY,ChenHZ,TianR,ZhanTX,ChenZ,NiZ*.Structuralandenergeticinsightsintotheselectiveinteractionsofmonoacylglycerollipasewithitsnaturalsubstrateandsmall-moleculeinhibitors.Med.Chem.Res.(Inpress,DOI:10.1007/s00044-013-0832-9).

10.JinX,LiuB,NiZ,et.al.Anovelcontrolofenzymaticenantioselectivitythroughtheracemictemperatureinfluencedbyreactionmedia.EnzymeMicro.Tech.2011,48:454-457.