个人简历

学习经历：\r
2000年9月-2004年6月，大学，动物医学专业，学士学位\r
2004年9月-2009年6月，博士，预防兽医专业，博士学位\r
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教学及研究经历：\r
2018年10月---至今江苏大学，食品与生物工程学院，硕士生导师\r
2018年10月---至今江苏省农业科学院，兽医所，研究员\r
2017年12月---至今江苏省农业科学院，兽医所，副所长\r
2015年9月-2016年9月斯坦福大学，医学院，访问学者\r
2012年12月---至今南京农业大学，动物医学院，硕导\r
2012年8月---2018年10月江苏省农业科学院，兽医所，副研究员\r
2009年8月-2012年7月江苏省农业科学院，兽医所，助理研究员\r
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荣誉：\r
教育部学位论文评议专家\r
江苏省双创人才\r
江苏省“333高层次人才培养工程”中青年科学技术带头人\r
江苏省“六大人才高峰”资助对象\r
江苏省科技社团（学会）优秀青年人才\r
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在研项目：\r
1. 国家自然科学基金面上项目，细胞骨架蛋白ADD1对A群轮状病毒的抑制作用及其分子机制，项目编号：31872481，资助年限：2019.01-2022.12；\r
2. 国家重点研发计划，猪呼吸道病原微生物共感染与协同致病机理。项目编号：2018YFD0500101，资助年限：2018.06-2020.12；\r
3. 第十三批六大人才高峰高层次人才资助项目，猪流行性腹泻疫苗与检测试剂盒创制。项目编号：NY-45，资助年限：2016.07-2019.06；\r
4. 江苏省地方标准，猪萨佩罗病毒(Porcine Sapelovirus, PSV)诊断技术。项目编号：5511611；\r
5. 国家重点研发计划，猪流行性腹泻病毒的遗传演化与免疫逃逸的分子基础。项目编号：2016YFD0500101，资助年限：2016.07-2020.12；\r
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结题项目：\r
1. 国家自然科学基金面上项目，猪肺炎支原体与PRRSV混合感染激活IL-1β的分子机制及生物学意义。项目编号：31472204，资助年限：2015.1-2018.12；\r
2. 江苏省双创计划，规模化猪场绿色健康新型养殖模式的创建。2015.7-2017.6；\r
3. 江苏省农业科学院基本科研业务专项，猪肺炎支原体和PRRSV共感染激活IL-1β的分子机制。2015.01-2015.12；\r
4. 江苏省自然科学基金面上项目，猪肺炎支原体与PRRSV混合感染激活IL-1β的分子机制研究。项目编号：BK20131330，资助年限：2013.7-2016.6；\r
5. 江苏省农业科技自主创新资金，猪流行性腹泻病毒系列诊断试剂盒研制。项目编号：CX(13)3069，资助年限：2013.7-2015.6；\r
6. 国家自然科学基金青年基金，猪肺炎支原体和猪繁殖与呼吸综合征病毒混合感染的分子机制研究，项目编号：31001066，资助年限：2011.1-2013.12；\r
7. 江苏省农业科技自主创新资金，猪博卡病毒新型分子诊断及抗体检测技术研究，项目编号：CX（11）4043，资助年限：2011.7-2013.6。

研究领域

""硕士研究生：生物技术、微生物、检测技术、动物病原微生物"""（1）生物技术，病原诊断与检测方法；（2）兽医微生物疫苗研发及致病机理研究；（3）猪病毒性腹泻防控技术研究；（4）新型免疫佐剂和抗原递呈系统的开发。"

近期论文

1. Ren L*, Ding S*#, Song Y*, Li B*, Co J, Ramanathan M, Amieva MR, Khavari PA, and Greenberg HB#. Profiling of rotavirus 3’ UTR binding proteins reveals ATP synthase subunit ATP5B as a novel host factor that supports late stage virus replication. J Biol. Chem. 2019, In Press.\r
2. Du L, Yu Z, Pang F, Xu X, Mao A, Yuan W, He K, Li B*. Targeted Delivery of GP5 Antigen of PRRSV to M Cells Enhances the Antigen-Specific Systemic and Mucosal Immune Responses. Front Cell Infect Microbiol. 2018, 25;8:7. doi: 10.3389/fcimb. \r
3. Bin Li, Luping Du, Zhengyu Yu, Bing Sun, Xiangwei Xu, Baochao Fan, Rongli Guo, Wanzhe Yuan, Kongwang He. Poly (D, L-lactide-co-glycolide) nanoparticle-entrapped vaccine induces a protective immune response against porcine epidemic diarrhea virus infection in piglets. Vaccine, 2017.15;35(50):7010-7017.\r
4. Bin Li, Siyuan Ding, Ningguo Feng, Nancie Mooney, Yaw Shin Ooi, Lili Ren, Jonathan Diep, Marcus R. Kelly, Linda L. Yasukawa, John T. Patton, Hiroyuki Yamazaki, Tomoaki Shirao, Peter K. Jackson, and Harry B. Greenberg*. Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. Proc Natl Acad Sci USA. 2017. 114(18):E3642-E3651.\r
5. Lin H, Li B, Chen L, Ma Z, He K, Fan H. Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of Infection. J Proteome Res. 2017, 16(6):2113-2120.\r
6. Fan B, Jiao D, Zhao X, Pang F, Xiao Q, Yu Z, Mao A, Guo R, Yuan W, Zhao P, He K, Li B*. Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome. Sci Rep. 2017, 7:44209.\r
7. Du L, Pang F, Yu Z, Xu X, Fan B, Huang K, He K, Li B*. Assessment of the efficacy of two novel DNA vaccine formulations against highly pathogenic Porcine Reproductive and Respiratory Syndrome Virus. Sci Rep. 2017, 7: 41886;\r
8. Luping Du, Bin Li, Fengjiao Pang, Zhengyu Yu, Xiangwei Xu, Baochao Fan, Yeping Tan, Kongwang He, Kehe Huang. Porcine GPX1 enhances GP5-based DNA vaccination against porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology, 2017, 183, 31-39.\r
9. Fan B, Yu Z, Pang F, Xu X, Zhang B, Guo R, He K, Li B*. Characterization of a pathogenic full-length cDNA clone of a virulent porcine epidemic diarrhea virus strain AH2012/12 in China. Virology. 2017 500, 50-61.\r
10. Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, Greenberg HB. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016, 5;12(10):e1005929.\r
11. Du L1, Bin Li (co-first author), Xu X, Sun B, Pang F, Wen L, Huang K, He K. Adsorption of a porcine reproductive and respiratory syndrome virus DNA vaccine candidate onto biodegradable nanoparticles improves immunogenicity in mice. Arch Virol. 2015, 160(6):1543-7.\r
12. Bin Li, Luping Du, Xiangwei Xu, Bing Sun, Zhengyu Yu, Zhixin Feng, Maojun Liu, Yanna Wei, Haiyan Wang, Guoqing Shao, Kongwang He.Transcription analysis on response of porcine alveolar macrophages to co-infection of the highly pathogenic porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Virus research, 2015, 196,60-69.\r
13. Bin Li, Luping Du, Bing Sun, Zhengyu Yu, Maojun Liu, Zhixin Feng, Yanna Wei, Haiyan Wang, Guoqing Shao, Kongwang He. Transcription Analysis of the Porcine Alveolar MacrophageResponse to Mycoplasma hyopneumoniae. PLoS ONE 2014, 9(8): e101968.\r
14. Luping Du, Bin Li (co-first author), Kongwang He, Haibin Zhang, Kehe Huang and Shaobo Xiao. Construction and Immunogenicity of DNA Vaccines Encoding Fusion Protein of Porcine IFN-1 and GP5 Gene of Porcine Reproductive and Respiratory Syndrome Virus. BioMed Research International, Volume 2013 (2013), Article ID 318698.\r
15. Bin Li*, Du L, Sun B, Yu Z, Wen L, Zhang X, Guo R, Ni Y, Hu Y, Zhou J, Zhu H, Lv L, Yu Y, Wang X, He K*. Monoclonal antibodies against Nsp2 protein of the highly pathogenic porcine reproductive and respiratory syndrome virus. Monoclon Antib Immunodiagn Immunother. 2013, 32(5): 362-365.\r
16. Bin Li*, Bing Sun, Lu-ping Du, Ai-hua Mao, Li-bin Wen, Yan-xiu Ni, Xue-han Zhang, Kong-wang He*. Development of a loop-mediated isothermal amplification assay for the detection of porcine hokovirus. J Virol Methods. 2013, 193(2): 415-418.\r
17. Bin Li*, Haofei Liu, Kongwang He, Rongli Guo, Yanxiu Ni, Luping Du, Libin Wen, Xuehan Zhang, Zhengyu Yu, Junming Zhou,Aihua Mao, Lixin Lv, Yiyi Hu, Yang Yu, Haodan Zhu, Xiaomin Wang. Complete genome sequence of a recombinant porcine epidemic diarrhea virus strain from eastern China. Genome Announc. 2013, 18;1(2): e00105-13.\r
18. Jianbo Cao, Bin Li (co-first author), Liurong Fang, Huanchun Chen, Shaobo Xiao. Pathogenesis of nonsuppurative encephalitis caused by highly pathogenic Porcine reproductive and respiratory syndrome virus. J Vet Diagn Invest. 2012, 24(4):767-71.\r
19. Bin Li*, Ma Junjie, Liu Yanling, Wen Libin, Yu Zhengyu, Ni Yanxiu, Zhang Xuehan, Zhou Junming, Guo Rongli, Wang Xiaomin, Feng Zhixin, Hu Yiyi, Lv Lixin, He Kongwang. Complete genome sequence of a highly prevalent porcine circovirus 2 isolated from piglet stool samples in China，J. Virol, 2012, 86(8), 4716.\r
20. Bin Li, Ma JJ, Xiao SB, Fang LR, Zeng SL, Wen LB, Zhang XH, Ni YX, Guo RL, Yu ZY, Zhou JM, Mao AH, Lv LX, Wang XM, He KW. Complete genome sequence of a novel species of porcine bocavirus, PBoV5. J. Virol. 2012, 86(2):1286–1287.\r
21. Bin Li, Ma JJ, Xiao SB, Wen LB, Ni YX, Zhang XH, Fang LR, He KW. Genome sequence of a highly prevalent porcine partetravirus in mainland China. J. Virol. 2012, 86:1899.\r
22. Bin Li, Ma JJ, Xiao SB, Zhang XH, Wen LB, Mao L, Ni YX, Guo RL, Zhou JM, Lv LX, He KW. Development of a loop-mediated isothermal amplification method for rapid detection of porcine boca-like virus. J. Virol. Methods. 2012, 179:390-395.\r
23. Bin Li, Liurong Fang, Xueliang Guo, Janfeng Gao, Tao Song, Jing Bi, Kongwang He, Huanchun, Chen, Shaobo Xiao. Epidemiology and Evolutionary Characteristics of the Porcine Reproductive and Respiratory Syndrome Virus in China between 2006 and 2010. J Clin Microbiol. 2011, 49 (9): 3175-3183.\r
24. Bin Li, Xiao SB, Ma JJ, Liu YL, Mao L, Wen LB, Mao AH, Zhang XH, Ni YX, Guo RL, Zhou JM, Yu ZY, Lv LX, Wang XM, Fang LR, Chen HC, He KW. Development of a novel TaqMan-based real-time PCR assay for the detection of porcine boca-like virus (Pbo-likeV). Virol. J. 2011, 8:357.\r
25. Bin Li, Liurong Fang, Suyan Liu, Fuwei Zhao, Yunbo Jiang, Kongwang He, Huanchun Chen, Shaobo Xiao The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009. Vet Microbiol. 2010, 146: 226-237.\r
26. Bin Li, Liurong Fang, Zuofei Xu, Suyan Liu, Jianfeng Gao, Yunbo Jiang, Huanchun Chen, Shaobo Xiao. Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome virus. Emerg Infect Dis. 2009, 15 (12): 2032-2035.\r
27. Bin Li, Shaobo Xiao, Yanwei Wang, Shanshan Xu, Yunbo Jiang, Huanchun Chen, Liurong Fang. Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene. Vaccine. 2009, 27: 1957-1963.
担任Sci Rep、Vet Microbiol、Arch Virol、PLoS ONE、J Virol Methods、Medicine、Protein & Peptide Letters等杂志审稿人。 兼任江苏省畜牧兽医学会副理事长，中国微生物学会兽医微生物学会青年委员，中国畜牧兽医学会兽医公共卫生学分会理事，江苏省兽医免疫学常务委员，江苏省农业科学院欧美同学会副会长。 教育部学位论文评议专家 江苏省双创人才 江苏省“333高层次人才培养工程”中青年科学技术带头人 江苏省“六大人才高峰”资助对象 江苏省科技社团（学会）优秀青年人才