个人简历

2013.09-2016-06 上海药物研究所 博士(药物设计)\r
2011.07-2013.06 上海药物研究所 硕士(药物设计)联合培养\r
2010.09-2013.06 福州大学 硕士(物理化学)\r
2006.09-2010.06 曲阜师范大学 学士(化学）\r
2016.07-至今 济南大学生物科学与技术学院 制药工程系讲师

研究领域

""理论模拟驱动的创新药/靶发现与作用机制研究""""

近期论文

Wang C, Xu P, Zhang L, Huang J, Zhu K*, Luo C*. Current Strategies and Applications for Precision Drug Design. Front Pharmacol. 2018; 9:787. (IF: 3.831)\r
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Zhu K, Tao H, Song JL, Jin L, Zhang Y, Liu J, Chen Z, Jiang CS*, Luo C*, Zhang H*. Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations. Bioorg Chem. 2018; 81: 289-298.\r
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Zhu K, Jiang C, Tao H, Liu J, Zhang H*, Luo C*. Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations. Bioorg Med Chem Lett. 2018; 28(9):1476-1483.\r
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Zhu K, Jiang CS, Hu J, Liu X, Yan X, Tao H, Luo C*, Zhang H*. Biochem Biophys Res Commun. 2018; 495(1):721-727. (IF: 2.559)\r
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Jiang CS, Zhuang CL, Zhu K, Zhang J, Muehlmann LA, Figueiró Longo JP, Azevedo RB, Zhang W, Meng N*, Zhang H*. Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy. J Enzyme Inhib Med Chem. 2018； 33(1):833-841. (co-first author, IF: 3.638)\r
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Mao R, Shao J, Zhu K, Zhang Y, Ding H, Zhang C, Shi Z, Jiang H, Sun D*, Duan W*, Luo C*. Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017; 60(14):6289-6304. (co-first author, IF: 6.253)\r
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Jiang J, Zheng C*, Zhu K, Liu J, Sun N, Wang C, Jiang H, Zhu J, Luo C*, Zhou Y*. Quantum chemistry calculation-aided structural optimization of combretastatin A-4-like tubulin polymerization inhibitors: improved stability and biological activity. J Med Chem. 2015; 58(5):2538-46. (co-first author, IF: 6.253)\r
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Zhang J, Liu H, Zhu K, Gong S, Dramsi S, Wang YT, Li J, Chen F, Zhang R, Zhou L, Lan L, Jiang H, Schneewind O*, Luo C*, Yang CG*. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci U S A. 2014. 111(37):13517-13522. (co-first author, IF: 9.504)\r
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Zhu K, Kong X, Zhao D, Liang Z, Luo C*. c-MET kinase inhibitors: a patent review (2011 - 2013). Expert Opin Ther Pat. 2014; 24(2):217-30.\r
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Zhu K, Lu J, Liang Z, Kong X, Ye F, Jin L, Geng H, Chen Y*, Zheng M, Jiang H, Li JQ, Luo C*. A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1. J Comput Aided Mol Des. 2013; 27(3):247-56. (IF: 2.356)\r
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Zhu K, Lu J, Ye F, Jin L, Kong X, Liang Z, Chen Y*, Yu K, Jiang H, Li JQ, Luo C*. Structure-based computational study of the hydrolysis of New Delhi metallo-β-lactmase-1. Biochem Biophys Res Commun. 2013; 431(1):2-7. (IF: 2.559)