个人简历

教育经历
2007.9 ~ 2010.7：博士，山东大学，免疫学
2000.9 ~ 2003.7：硕士，山东省医学科学院，免疫学
1995.9 ~ 2000.7：学士，泰山医学院，临床医学
工作经历
2015.9 ~至今： 暨南大学 研究员
主要研究固有免疫细胞发育和功能的代谢调控
2011.9 ~ 2015.9： 清华大学医学院， 博士后 主要研究PI3K途径关键分子调节NK细胞发育、稳态维持和功能机制。
2003.7 ~ 2011.9：山东大学齐鲁医院临床基础研究所，副主任技师 主要研究低氧微环境对免疫细胞生物学行为的影响

研究领域

1．T-box家族转录因子Eomes和T-bet调控自然杀伤细胞发育和功能的机制研究
2．PI3K-mTOR信号通路相关分子调控自然杀伤细胞发育和功能的时序性研究
3．自然杀伤细胞发育分化和免疫记忆形成的代谢调节

近期论文

Chen S, Cai C, Li Z, Liu G, Wang Y, Blonska M, Li D, Du J, Lin X, Yang M, Dong Z.Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity. J Exp Med.2017.（IF：11.24）
Yang M, Chen S, Du J, He J, Wang Y, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P,Guo W, Chang Z, Wang S, Tian Z, Dong Z. NK cell development requiresTsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. NatCommun. 2016 ;7:12730.（共同第一作者）（IF：11.329）
Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z, Dong Z. The self-specific activation receptor SLAM family is critical for NK cell education. Immunity. 2016;45(2):292-304.（共同第一作者）（IF：24.082）
Sun J, Yang M, Ban Y, Gao W, Song B, Wang Y, Zhang Y, Shao Q, Kong B, Qu X.Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. PLoS One. 2016;11(1):e0147186. （IF：3.057）
Du J, Yang M, Chen S, Li D, Chang Z, Dong Z. PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model.Oncogene. 2016;35(25):3314-23.（IF：7.932）
Yang M, Liu Y, Ren G, Shao Q, Gao W, Sun J, Wang H, Ji C, Li X, Zhang Y, Qu X.Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward aTh2 polarization. Sci Rep. 2015;5:13674.（共同第一作者）（IF：5.228）
Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Exp Med.2015. 212(2):253-65. （IF：11.24）
Sun J, Feng A, Chen S, Zhang Y, Xie Q, Yang M, Shao Q, Liu J, Yang Q, Kong B, Qu X. Osteopontin splice variants expressed by breast tumors regulate monocyte activation via MCP-1 and TGF-β1. Cell Mol Immunol. 2013;10(2):176-82（IF：5.193）
Shao Q, Ning H, Lv J, Liu Y, Zhao X, Ren G, Feng A, Xie Q, Sun J, Song B, Yang Y, Gao W, Ding K, Yang M, Hou M, Peng J, Qu X. Regulation of Th1/Th2 polarization by tissue inhibitor of metalloproteinase-3 via modulating dendritic cells. Blood. 2012;119(20):4636-44.
Yang M, Ma C, Liu S,Shao Q, Gao W, Song B, Sun J, Xie Q, Zhang Y, Feng A, Liu Y, Hu W, Qu X. HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia. Immunol Cell Biol.2010,88(2):165-71.（IF:4.473）
Sun J, Zhang Y, Yang M,Zhang Y, Xie Q, Li Z, Dong Z, Yang Y, Deng B, Feng A, Hu W, Mao H, Qu X. Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A(2). Cell Mol Immunol. 2010;7(1):77-82
Yang M, Ma C, Liu S, Sun J, Shao Q, Gao W, Zhang Y, Li Z, Xie Q, Dong Z, Qu X.Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumor cell migration by dendritic cells-derived osteopontin. Immunology. 2009, 128(1):e237-49. (IF:4.078)
Yang M，Ma C, Sun J, Shao Q, Gao , Zhang Y, Li Z, Xie Q, Dong Z, Qu X.Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells. Int Immunopharmacol. 2008, 8(13-14):1754-60. (IF:2.551)
Qu X, Yang M, Zhang W, Liang L, Yang Y, Zhang Y, Deng B, Gao W, Liu J, Yang Q, Kong B, Gong F.Osteopontin expression in human decidua is associated with decidual natural killer cells recruitment and regulated by progesterone. In Vivo. 2008, 22(1):55-61.(共同第一作者) (IF:1.2)
Zhao P, Li X, Yang M,Shao Q, Wang D, Liu S, Song H, Song B, Zhang Y, Qu X.Hypoxia suppresses the production of MMP-9 by human monocyte- derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway. Mol Immunol. 2008, 45(8):2187-95.
Yang M,Qu X, Kong B, Lam QL, Shao QQ, Deng BP, Ko KH, Lu L. Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes-derived dendritic cells. Immunol Cell Biol. 2006, 84(6):557-62. (IF:4.473)
QuX, Yang M,Kong B, Qi L, Lam QL, Yan S, Li P, Zhang M, Lu L. Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells.Immunol Cell Biol. 2005, 83(6):668-73.(IF:4.473)