个人简历

教育经历
1992年－1996年，中山大学，生命科学院，本科生，生物学专业
1996年－1999年，中山大学，生命科学院，硕士研究生，微生物学
2002年－2005年，暨南大学，生命科学与技术学院，在职博士研究生，生物化学与分子生物学专业
工作经历
1999年－2002年，暨南大学，生命科学与技术学院，研究实习员
2002年－2005年，暨南大学，生命科学与技术学院，助理研究员
2006年－今， 暨南大学，生命科学与技术学院，副研究员

研究领域

神经肽/脑肠肽垂体腺苷酸环化酶激活多肽PACAP/血管活性肠肽VIP及其B类G蛋白偶联受体的生物学研究及相关药物研发

近期论文

1.Huang X, Li J, Song S, Wang L, Lin Z, Ouyang Z, Yu R*. Hormesis effect of hydrogen peroxide on the promoter activity of neuropeptide receptor PAC1-R. J Food Biochem. 2019 Jul;43(7):e12877.
2.Song S, Wang L, Li J, Huang X, Yu R*. The allosteric modulation effects of doxycycline, minocycline, and their derivatives on the neuropeptide receptor PAC1-R. Acta Biochim Biophys Sin (Shanghai). 2019 Jun 20;51(6):627-637.
3.Atlasz T*, Werling D, Song S, Szabo E, Vaczy A, Kovari P, Tamas A, Reglodi D,Yu R*. Retinoprotective Effects of TAT-Bound Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase Activating Polypeptide. J Mol Neurosci. 2019 Jul;68(3):397-407.
4.Yu R*, Liu H, Peng X, Cui Y, Song S, Wang L, Zhang H, Hong A, Zhou T The palmitoylation of the N-terminal extracellular Cys37 mediates the nuclear translocation of VPAC1 contributing to its anti-apoptotic activity.Oncotarget. 2017 Jun 27;8(26):42728-42741.
5.Yu R*, Zheng L, Cui Y, Zhang H, Ye H. Doxycycline exerted neuroprotective activity by enhancing the activation of neuropeptide GPCR PAC1.Neuropharmacology. 2016 Apr;103:1-1.
6..Guo X, Yu R*, Xu Y, Lian R, Yu Y, Cui Z, Ji Q, Chen J, Li Z, Liu H, Chen J*. PAC1R agonist maxadilan enhances hADSC viability and neural differentiation potential.J Cell Mol Med. 2016 May;20(5):874-90. 7.
7.Yu R*, Cui Z, Li M, Yang Y, Zhong J. Dimer-dependent intrinsic/basal activity of the class B G protein-coupled receptor PAC1 promotes cellular anti-apoptotic activity through Wnt/β-catenin pathways that are associated with dimer endocytosis. PLoS One. 2014 Nov 26;9(11) :e113913.
8.Yu R*, Yang Y, Cui Z, Zheng L, Zeng Z, Zhang H. Novel peptide VIP-TAT with higher affinity for PAC1 inhibited scopolamine induced amnesia. Peptides. 2014 Oct;60:41-50.
9.Yu R*, Zhong J, Li M, Guo X, Zhang H, Chen J. PACAP induces the dimerization of PAC1 on the nucleus associated with the cAMP increase in the nucleus. Neurosci Lett. 2013 Aug 9;549:92-6.
10.Yu R*, Guo X, Zhong J, Li M, Zeng Z, Zhang H. The N-terminal HSDCIF motif is required for cell surface trafficking and dimerization of family B G protein coupled receptor PAC1. PLoS One. 2012;7(12):e15811.