徐石海
近期热点
资料介绍
个人简历
学习经历1993 / 09 – 1996 / 07, 中山大学,化学系,博士;1990 / 09 – 1993 / 07, 湘潭大学,化学系,硕士;1985 / 09-1988 / 06,湖南邵阳学院,化学系,学士。工作经历2016/04-现在,暨南大学化学与材料学院,教授2008/03-2008/09,美国密西西比大学,药学院高访;2002/10-2016/04,暨南大学生命科学与技术学院,教授;1998/10-2002/10,暨南大学生命科学与技术学院,副教授;1996/07-1998/10,暨南大学理工学院,讲师。研究领域
1、海洋天然产物分离:对南海海洋生物海绵、珊瑚、海藻及其共附生微生物种次生代谢产物进行提取、分离与结构鉴定;2、活性研究:海洋生物单体次生代谢产物的抗肿瘤、抗菌、抗海洋污损的活性研究;3、有机合成及其方法学:强活性海洋生物次生代谢产物的全合成、结构修饰及其合成方法学研究;4、活性次级代谢产物的应用开发:将抗肿瘤、抗菌与抗海洋污损的活性代谢产物应用到海洋药物、化妆品、海洋污损涂料中。海洋生物的“分离—活性—合成—应用”从基础到应用四个连续研究方向近期论文
1、Chen, Shengtian(#),Wang, Junfeng,Lin, Xiuping,Zhao, Bingxin,Wei, Xiaoyi,Li, Guangqiang,Kaliaperumal, Kumaravel,Liao, Shengrong,Yang, Bin,Zhou, Xuefeng,Liu, Juan,Xu, Shihai(*),Liu, Yonghong(*),Chrysamides A-C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001,Organic Letters,2016,18(15):3650~36532、Ding, Li-Jian(#),Yuan, Wei,Liao, Xiao-Jian,Han, Bing-Nan,Wang, Shu-Ping,Li, Zhi-Yong,Xu, Shi-Hai(*),Zhang, Wei(*),Lin, Hou-Wen(*),Oryzamides A-E, Cyclodepsipeptides from the Sponge-Derived Fungus Nigrospora oryzae PF18,Journal of Natural Products,2016,79(8):2045~20523、Zhi-ran Ju(#),Xiaochu Qin,Xiu-ping Lin,Jun-feng Wang,Kumaravel Kaliyaperuma,Yong-qi Tian,Juan Liu,Fen Liu,Zhengchao Tu,Shi-hai Xu(*),Yong-hong Liu(*),New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel,Natural Product Research,2016,30(2):192~1984、Peng, Qi(#),Liu, Fen,Sun, Huan,Liao, Xiao-Jian,Feng, Mei-Ran,Liu, Ting-Ting,Xu, Zheng-Xiong,Zhang, Jun(*),Xu, Shi-Hai(*),A new sesquiterpene from the gorgonian coral Menella sp.,Natural Product Research,2016,30(20):2299~23045、 Ding, Li-Jian(#),Yuan, Wei,Li, Ying-Xin,Liao, Xiao-Jian,Sun, Huan,Peng, Qi,Han, Bing-Nan,Lin, Hou-Wen,Li, Zhi-Yong(*),Yang, Fan(*),Xu, Shi-Hai(*),Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii,Natural Product Research,2016,30(14):1633~16386、 Ding, Lijian(#),Yuan, Wei,Peng, Qi,Sun, Huan,Xu, Shihai(*),Secondary Metabolites Isolated from the Sponge-Associated Fungus Nigrospora oryzae,Chemistry of Natural Compounds,2016,52(5):969~9707、 Sun, Huan(#),Liu, Fen,Feng, Mei-Ran,Peng, Qi,Liao, Xiao-Jian,Liu, Ting-Ting,Zhang, Jun(*),Xu, Shi-Hai(*),Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.,Natural Product Research,2016,30(24):2819~28248、 Li-Jian Ding(#),Bin-Bin Gu,Wei-Hua Jiao,Wei Yuan,Ying-Xin Li,Wei-Zhuo Tang,Hao-Bing Yu,Xiao-Jian Liao,Bing-Nan Han,Zhi-Yong Li(*),Shi-Hai Xu(*),Hou-Wen Lin(*),New Furan and Cyclopentenone Derivatives from the Sponge-Associated Fungus Hypocrea Koningii PF04,Marine Drugs,2015,13(9):5579~55929、Liu, Fen(#),Li, Shuo,Ju, Zhi-Ran,Liu, Ting-Ting,Liang, Rui-Yu,Liao, Xiao-Jian,Xu, Shi-Hai(*),N-(3-aminopropyl)subergorgamide, a new alkaloid from the gorgonian Paraplexaura sp.,Journal of Asian Natural Products Research,201,17(8):851~85510、 Zhang, Jun(#),Liu, Ling-Li,Zhong, Ba-Lian,Liao, Xiao-Jian,Xu, Shi-Hai(*),9,11-Secosteroids with cytotoxic activity from the South China Sea gorgonian coral Subergorgia suberosa,Steroids,2015,98:100~10611、Jun Zhang(#),Xiu-Ping Lin,Liang-Chun Li,Ba-Lian Zhong,Xiao-Jian Liao,Yong-Hong Liu(*),Shi-Hai Xu(*),Gliomasolides A-E, unusual macrolides from a sponge-derived fungus Gliomastix sp ZSDS1-F7-2,RSC Advances,2015,5(67):54645~5464812、 Chusheng Liu(#),Weijia Chen,Guangxin Yuan,Yao Xiao,Jacques Crommen,Shihai Xu(*),Zhengjin Jiang(*),Influence of the crosslinker type on the chromatographic properties ofhydrophilic sulfoalkylbetaine-type monolithic columns,Journal of Chromatography A,2014,1373(1):73~8013、Chun Qin(#),Xiuping Lin,Xin Lu,Junting Wan,Xuefeng Zhou,Shengrong Liao,Zhengchao Tu,Shihai Xu(*),Yonghong Liu(*), Sesquiterpenoids and xanthones derivativesproduced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2 ,The Journal of Antibiotics,2014,67(6):1~514、Jun Zhang(#),Yan Liang,Liang-Chun Li,Shi-Hai Xu(*),Suberosanones A-C, New Metabolites Possessing Cyclopentenone System from the South China Sea Gorgonian Coral Subergorgia suberosa,Helvetica Chimica Acta,2014,97(1):128~13615、Xi Xiao(#),Xiaojian Liao,Shaoling Qiu,Zihao Liu,Bin Du(*),Shihai Xu(*),Paper Synthesis, Cytotoxicity and Apoptosis Induction in Human Tumor Cells by Galaxamide and Its Analogues,Marine Drugs,2014,12(8):5421~543816、 Jun Zhang(#),Yan Liang,Xiao-Jian Liao,Zhou Deng,Shi-Hai Xu(*),Isolation of a new butenolide from the South China Sea gorgonian coral Subergorgia suberosa,Natural Product Research,2014,28(3):150~15517、 Jun Zhang(#),Liang-Chun Li,Kai-Ling Wang,Xiao-Jian Liao,Zhou Deng,,Shi-Hai Xu(*),Pentacyclic hemiacetal sterol with antifouling and cytotoxic activities from the soft coral Nephthea sp.,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(4):1079~108218、 Jun Zhang(#),Yan Liang,Kai-Ling Wang,Xiao-Jian Liao,Zhou Deng,Shi-Hai Xu(*),Antifouling steroids from the South China Sea gorgonian coral Subergorgia suberosa,Steroids,2014,79(1):1~619、Jun Zhang(#),Yan Liang,Liangchun Li,Shaihai Xu(*),Suberosanones A–C, New Metabolites Possessing Cyclopentenone System from the South China Sea Gorgonian Coral Subergorgia suberosa,Helvetica Chimica Acta,2014,97(1):128~13620、 Jun Zhang(#),Xiao-Jian Liao,Kai-Ling Wang,,Zhou Deng,Shi-Hai Xu(*),Cytotoxic cholesta-1,4-dien-3-one derivatives from soft coral Nephthea sp.,STEROIDS,2013,78(4):396~40021、Wang Changjun(*),Liang Yuanwei,Liao Xiaojian,Xu Shihai,Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid,Chinese Journal of Organic Chemistry,2012,32(4):727~73122、 Xiao-Jian Liao(#),Li-Dan Tang,Yuan-Wei Liang,Shui-Lian Jian,,Shi-Hai Xu,(*),Yong-Hong Liu(*),New Pentahydroxylated Steroids from the South China Sea Gorgonian Subergorgia suberosa,Chemistry and Biodiversity,2012,9(2):370~37523、 Yuan-wei Liang(#),Xiao-jian Liao,Chang-jun Wang,Jin-zhi Guo,Shuo Li,Shi-hai Xu(*),The first total synthesis of fuscain,JOURNAL OF CHEMICAL RESEARCH,2012,36(12):736~737 相关热点
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