个人简历

2007.12-至今，暨南大学生命科学技术学院化学系，教授，博士生导师。
2000.9-2007.11，中山大学化学与化学工程学院，副教授，博士生导师；
1998-2000，中山大学化学与化学工程学院，博士后；
1995-1998，东北师范大学化学院；博士生

研究领域

生物无机化学，化学生物学，生物化学与分子生物学；主要从事创新药物（包括化学合成药物、纳米药物、纳米载药、生物医药）、药物化学、分子生物学、细胞生物学等交叉学科的研究；研究兴趣主要集中在以下几个方面：(1) 开展了阿尔兹海默综合症（老年痴呆症，AD）抑制剂的研究：针对AD药物的多个主要靶点，开展了多靶点纳米颗粒抑制阿尔兹海默综合症药物的研究与开发，发现有可能成为AD候选药物的多功能纳米颗粒。(2) 靶向纳米药物制备及生物活性的研究，主要研究功能化纳米硒、纳米金等对肿瘤血管的抑制作用及抑制肿瘤转移的功能；(3) 肿瘤诊断试剂的研究与应用，设计合成一类近红外的小分子荧光探针，该探针能够识别肿瘤细胞，具有作为肿瘤诊断试剂的可能性。 (4) 金属配合物抗肿瘤作用机制，包括抗肿瘤作用靶点，诱导细胞凋亡信号传导途径，基因组学和蛋白组学方法研究金属配合物对肿瘤相关基因、蛋白的调控和生物效应的影响。(5) 配合物稳定端粒DNA的能力及其以端粒酶为靶点的抗肿瘤活性；重点研究手性异构体配合物及微环境的改变对其生物功能的影响，以及选择性识别并诱导端粒DNA构型的改变等。

近期论文

1.Xiaoquan Huang,Xu Chen,Qingchang Chen,Qianqian Yu,Dongdong Sun,bJie Liu. “Investigation of Functional Selenium Nanoparticles as Potent Antimicrobial Agents against superbugs.” Acta Biomaterialia(2016),(IF=6.02)
2.Wenjing Zheng, Qingchang Chen, Xiuying Qin, Xiaoquan Huang, Shuang Zhao, Taoyuan Xu, Lanmei Chen, Jie Liu. “Co-delivery of Se Nanoparticles and Pooled SiRNAs for Overcoming Drug Resistance Mediated by P-glycoprotein and Class III β-tubulin in Drug-resistant Breast Cancers”. Acta Biomaterialia (2016), (IF=6.02)
3.Yanhui Zhou, Qianqian Yu, Xiuying Qin, Dhairya Bhavsar, Licong Yang, Qingchang Chen, Wenjing Zheng, Lanmei Chen, and Jie Liu.“Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells.” ACS Applied Materials & Interfaces,DOI: 10.1021/acsami.5b02261，(IF=6.73)
4.Tiantian Yin, Licong Yang, Yanan Liu, Xianbo Zhou, Jing Sun, Jie Liu.“Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease”.Acta Biomaterialia,2015,25,172-180, (IF=6.02)
5.Xianbo Zhou, Chengwen Cao, Qingchang Chen, Qianqian Yu, Yanan Liu, Tiantian Yin and Jie Liu. “PEG Modified Graphene Oxide loaded with EALYLV Peptides for Inhibiting the Aggregation of hIAPP Associated with Type-2 Diabetes”. Journal of Materials Chemistry B,2015,3,7055-7067,(IF=4.72)
6.Xianbo Zhou, Jing Sun, Tiantian Yin, Fangling Le, Licong Yang, Yanan Liu and Jie Liu.“Enantiomers of cysteine-modified SeNPs (D/LSeNPs) as inhibitors of metal-induced Aβ aggregation in Alzheimer's disease”. Journal of Materials Chemistry B, 2015，3( 39), 7764-7774,(IF=4.72).
7.Xu Chen, Xiaoquan Huang, Chuping Zheng, Yanan Liu, Taoyuan Xu and Jie Liu. “Preparation of different sized nano-silver loaded on functionalized graphene oxide with highly effective antibacterial properties”. Journal of Materials Chemistry B, 2015,3,7020-7029, (IF=4.72).
8.Wenjing Zheng, Chengwen Cao, Yanan Liu, Qianqian Yu, Chuping Zheng, Dongdong Sun, Xiaofan Ren, Jie Liu. “Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance”. Acta Biomaterialia, 2015,11,368-380, (IF=6.02)
9.Qingchang Chen, Qianqian Yu, Yanan Liu, Dhairya Bhavsar, Licong Yang, Xiaofan Ren, Dongdong Sun, Wenjing Zheng, and Jie Liu. “Multifunctional selenium nanoparticles: Chiral selectivity of delivering MDR-siRNA for reversal of multidrug resistance and real-time biofluorescence imaging”. Nanomedicine: Nanotechnology, Biology, and Medicine.2015，11，1773–1784, (IF=6.15)
10.Jing Sun, Yongchao Huang, Chuping Zheng, Yanhui Zhou, Ying Liu, Jie Liu. Ruthenium (II) Complexes Interact with Human Serum Albuminand Induce Apoptosis of Tumor Cells Biol Trace Elem Res (2015) 163:266–274
11.Dongdong Sun , Yanan Liu, Qianqian Yu, Du Liu, Yanhui Zhou, Jie Liu, Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA. J. Inorg. Biochem.2015,150, 90–99.
12.Chuping Zheng, Jinsheng Wang, Yanan Liu,Qianqian Yu, Ying Liu, Ning Deng*, Jie Liu*. Functional Selenium Nanoparticles Enhanced Stem Cell Osteoblastic Differentiation through BMPSignaling Pathways. Advanced Functional Materials,2014, 24, 6872-6883(已接受）(IF=10.4).
13.Ying Liu, Yanan Liu*, Licong Yang,Chengwen Cao, Yanhui Zhou, Qianling Zhang, Jie Liu*Stabilization for Loop Isomers of C-Myc G-Quadruplex DNA and Anticancer Activity by Ruthenium Complexes. MedChemComm. 2014，5，1724–1728
14.Qingchang Chen, Licong Yang, Chuping Zheng, Wenjing Zheng, Jingnan Zhang, Yunshan Zhou, Jie Liu*. Mo polyoxometalate nanoclusters capable of inhibiting the aggregation of Ab-peptide associated with Alzheimer’s diseas.Nanoscale.2014, 6 (12), 6886 - 6897 (IF=7.3)
15.Qianqian Yu, Yanan Liu*, Lei Xu, Chuping Zheng, Fangling Le, Xiuying Qin,Yanyu Liu, Jie Liu*.Ruthenium(II) polypyridyl complexes: Cellular uptake, cell image andapoptosis of HeLa cancer cells induced by double targets.Eur. J. Med. Chem. 2014,82-95.
16.Licong Yang, Qingchang Chen, Ying Liu, Jingnan Zhang,Dongdong Sun, Yanhui Zhou, Jie Liu*. Se/Ru nanoparticles as inhibitors of metal-induced Aβaggregation in Alzheimer's disease. Journal of Materials Chemistry B. 2014, 2,1977-1987.4.7
17.Qianqian Yu, Yanan Liu, Chengwen Cao, Fangling Le, Xiuying Qin, DongdongSun, Jie Liu*.The Use of pH-sensitive Functional Selenium NanoparticlesShows Enhanced in vivo VEGF-siRNA Silencing and Fluorescence Imaging. Nanoscale, 2014,6, 9279–9292(IF=6.7)
18.Jingnan Zhang,Xianbo Zhou,Qianqian Yu, Licong Yang, Dongdong Sun, Yanhui Zhou, Jie Liu*. Epigallocatechin-3-gallate (EGCG)-Stabilized Selenium Nanoparticles Coated with Tet‑1Peptide To Reduce Amyloid‑β Aggregation andCytotoxicity. ACS. Appl. Mater. Int.2014, 6, 8475−8487(IF=5.9)
19.Xiu-Ying Qin, Ya-Nan Liu, Qian-Qian Yu, Li-Cong Yang, Ying Liu, Yan-Hui Zhou*,Jie Liu*. Mixed-Ligand Mononuclear Copper(II) Complex: Crystal Structure and Anticancer Activity. ChemMedChem.2014,9(8):1665-71
20.Wenjing Zheng, Licong Yang, Ying Liu, Xiuying Qin, Yanhui Zhou, YunshanZhou*, Jie Liu*, Mo polyoxometalates nanoparticles inhibit tumor growth and vascularendothelial growth factor induced angiogenesis.Science and Technology of Advanced Materials. 15 (2014) 035010,1-14