个人简历

教育背景
2004/09-2009/07 硕博连读南开大学生命科学学院
2000/09-2004/07 本科南开大学生命科学学院
工作经历
2017/03 副教授波兰科学院物理化学研究所华沙波兰
2017/02 Habilitation特许任教资格获得
2016/02-2016/05 访问教授美国威斯康辛麦迪逊大学
2009/07-2017/02 助理教授波兰科学院物理化学研究所华沙波兰

研究领域

1. 微塑料纳米粒子污染
将激光束聚焦在一个几十纳米的狭小区域，将该激光共聚焦区送达到细胞内指定位置进而捕获光子信息，然后将这些信息进行自相关数学处理从的得到我们想要的观测物数据，这就是激光荧光相关谱技术。微塑料纳米粒子在细胞内到底是如何分布？在哪些区域含量高？能否进入细胞核？传统技术很难捕获这些信息。本研究旨在通过激光荧光相关谱等先进光学技术，研究微塑料纳米粒子在生物体细胞内的分布。
2. 大分子拥挤微环境下的生物反应
现实的生物反应发生在大分子拥挤环境中，如细胞间质，细胞质，黏膜等存在着大量的生物大分子，DNA，RNA，蛋白质，纤维等。该大分子拥挤微环境对于其中的生物反应有着重要影响，然而当今的实验室研究往往忽略了微环境的影响因素。本研究旨在研究大分子拥挤微环境对于微塑料污染的影响

近期论文

1.Jiajia Jiao, Lili Sun, Zaiyu Guo, Sen Hou, Robert Holyst, Yun Lu, Xizeng Feng. Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone). Sci. Rep., 6, 2016, DOI: 10.1038/srep38973.
2.Xuzhu Zhang, Andrzej Poniewierski, Aldona Jelińska, Anna Zagożdżon, Agnieszka Wisniewska, Sen Hou, Robert Hołyst. Determination of equilibrium and rate constants for complex formation by fluorescence correlation spectroscopy supplemented by dynamic light scattering and Taylor dispersion analysis. Soft Matter, 12, 2016, 8186-8194.
3.Shengju Zhou, Piotr Trochimczyk, Lili Sun, Sen Hou*, Hongguang Li. Sugar-Functionalized Fullerenes. Curr. Org. Chem., 20, 2016, 1490-1501.
4.Lili Sun, Marcin Tabaka, Sen Hou, Lin Li, Krzysztof Burdzy, Aleksei Aksimentiev, Christopher Maffeo, Xuzhu Zhang, Robert Holyst. The hinge region strengthens the nonspecific interaction between Lac- repressor and DNA: a computer simulation study. PLoS One, 2016, DOI:10.1371/journal.pone.0152002.
5.Sen Hou*, Piotr Trochimczyk, Lili Sun, Agnieszka Wisniewska, Tomasz Kalwarczyk, Xuzhu Zhang, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Robert Holyst. How can macromolecular crowding inhibit biological reactions? The enhanced formation of DNA nanoparticles. Sci. Rep., 6, 2016, DOI: 10.1038/srep22033.
6.Tomasz Kalwarczyk, Krzysztof Sozanski, Anna Ochab-Marcinek, Jedrzej Szymanski, Marcin Tabaka, Sen Hou, Robert Holyst. Motion of nanoprobes in complex liquids within the framework of the length-scale dependent viscosity model. Adv. Colloid Interface Sci., 223, 2015, 55-63.
7.Song Ren, Ming Wu, Jiayu Guo, Wang Zhang, Xiaohan Liu, Lili Sun, Robert Holyst, Sen Hou*, Yongchun Fang, Xizeng Feng. Sterilization of polydimethylsiloxane surface with Chinese herb extract: a new antibiotic mechanism of chlorogenic acid. Sci. Rep., 5, 2015, DOI: 10.1038/srep10464.
8.Xuzhu Zhang, Andrzej Poniewierski, Sen Hou, Krzysztof Sozański, Agnieszka Wisniewska, Stefan A. Wieczorek, Tomasz Kalwarczyk, Lili Sun, Robert Holyst. Tracking structural transitions of bovine serum albumin in surfactant solutions by fluorescence correlation spectroscopy and fluorescence lifetime analysis. Soft Matter, 11, 2015, 2512-2518.
9.Marcin Tabaka, Tomasz Kalwarczyk, Jedrzej Szymanski, Sen Hou, Robert Holyst. The effect of macromolecular crowding on mobility of biomolecules, association kinetics, and gene expression in living cells. Frontiers in Physics, 2, 2014, doi: 10.3389/fphy.2014.00054
10.Tomasz Kalwarczyk, Krzysztof Sozanski, Slawomir Jakiela, Agnieszka Wisniewska, Ewelina Kalwarczyk, Katarzyna Kryszczuk, Sen Hou, Robert Holyst. Length-scale dependent transport properties of colloidal and protein solutions for prediction of crystal nucleation rates. Nanoscale, 6, 2014, 10340-10346
11.Sen Hou*, Marcin Tabaka, Lili Sun, Piotr Trochimczyk, Tomasz S Kaminski, Tomasz Kalwarczyk, Xuzhu Zhang, Robert Holyst. A flexible fluorescence correlation spectroscopy based method for quantification of the DNA double labeling efficiency with precision control. Laser Phys. Lett., 11, 2014, 085602
12.Sen Hou*, Lili Sun, Stefan A. Wieczorek, Tomasz Kalwarczyk, Tomasz S. Kaminski, Robert Holyst. Fluorescence correlation spectroscopy analysis for accurate determination of proportion of doubly labeled DNA in fluorescent DNA pool for quantitative biochemical assays. Biosens. Bioelectron., 51, 2014, 8-15.
13.Sen Hou, Stefan A. Wieczorek, Tomasz S. Kaminski, Natalia Ziebacz, Marcin Tabaka, Nohemy A. Sorto, Marie H. Foss, Jared T. Shaw, Martin Thanbichler, Douglas B. Weibel, Krzysztof Nieznanski, Robert Holyst, Piotr Garstecki. Characterization of caulobacter crescentus FtsZ protein using dynamic light scattering. J. Biol. Chem., 287, 2012, 23878-23886.
14.Sen Hou, Natalia Ziebacz, Stefan A. Wieczorek, Ewelina Kalwarczyk, Volodymyr Sashuk, Tomasz Kalwarczyk,Tomasz S. Kaminski and Robert Holyst. Formation and structure of PEI/DNA complexes: quantitative analysis. Soft Matter, 7, 2011, 6967-6972.
15.Yang Yao, Dao-Fu Feng, Yi-Pan Wu, Qi-Jun Ye, Lei Liu, Xin-Xin Li, Sen Hou, Yan-Lian Yang, Chen Wang, Lei Li and Xi-Zeng Feng. Influence of block sequences in polymer vectors for gene transfection in vitro and toxicity assessment of zebrafish embryos in vivo. J. Mater. Chem., 21, 2011, 4538.
16.Sen Hou, Natalia Ziebacz, Tomasz Kalwarczyk, Tomasz S. Kaminski, Stefan A. Wieczorek, Robert Holyst. Influence of nano-viscosity and depletion interactions on cleavage of DNA by enzymes in glycerol and poly(ethylene glycol) solutions: qualitative analysis. Soft Matter, 7, 2011, 3092-3099.
17.Sen Hou, Xinxin Li, Xiaoyu Li, Xizeng Feng. Coating of hydrophobins on three-dimensional electrospun poly(lactic-co-glycolic acid) scaffolds for cell adhesion. Biofibrication 1, 2009, 35004.
18.Sen Hou, Yongzheng Ma, Xinxin Li, Xizeng Feng, Yudong Zhang, Xiaokun Dong, Yongchun Fang. Porous film fabricated by a thermoresponsive polymer poly (N-isopropylacrylamide-co-butylmethacrylate) with enhanced hydrophobicity. Colloid Surf. A-Physicochem. Eng. Asp., 246, 2009, 164-169.
19.Sen Hou, Xinin Li, Xi-Zheng Feng. Method to Improve DNA Condensation Efficiency by Alkali Treatment. Nucleos. Nucleot. Nucl., 28, 2009, 1532-2335.
20.Sen Hou, Xin-Xin Li, Xiao-Yu Li, Xi-Zeng Feng, Rui Wang, Chen Wang, Lei Yu, Ming-Qiang Qiao. Patterning of 293T fibroblasts on a mica surface. Anal. Bioanal. Chem., 394, 2009, 2111-2117.