个人简历

学习经历:
1978.9-1983.7 华西医科大学医学院 临床医学专业 本科生
1985.9-1988.7 在华西医科大学基础医学院 攻读药理学硕士学位
1998.9–2001.7 在华西医科大学基础医学院 攻读病理生理学博士学位
海外学习经历：
1999年1月–2002年12月 在日本名古屋大学医学部进修学习

工作经历:
1977.2-1978.8 四川化工厂科研科 实验员
1983.8-2002.7 华西医科大学基础医学院药理教研室先后任助教、讲师、副教授
2002.7-今 暨南大学药学院 先后任副教授、教授、硕士生、博士生导师、药学系系主任、副院长。

研究领域

肿瘤与免疫药理学
临床药理学

近期论文

1. Wang XX, Xu J, Wang H, Wu L, Yuan WQ, Du J, Cai SH. Trichostatin A, a histone deacetylase inhibitor, reverses epithelial–mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. Biochem. Biophys. Res. Commun:456:320-326,2015.
2. L. Wu, J. Xu, W. Yuan, B. Wu, H. Wang, G. Liu, X. Wang, J. Du and S. Cai:The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells.PLoS One:1932-6203 .2014.
3. Jun Xu ,Sichao Huang ,Tiantian Zhang ,Nong Wu ,Hongjun Kang , Shaohui Cai ,Weizai Shen:The SAR studies on FAP inhibitors as tumor-targeted agents.Med Chem Res:0888-5885.2014.
4. X.-F. Wang, H.-S. Wang, H. Wang, F. Zhang, K.-F. Wang, Q. Guo, G. Zhang, S.-H. Cai and J. Du: The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells. Cellular Immunology:0008-8749,2014.
5. H. Wang, H. S. Wang, B. H. Zhou, C. L. Li, F. Zhang, X. F. Wang, G. Zhang, X. Z. Bu, S. H. Cai and J. Du:Epithelial-mesenchymal transition (EMT) induced by TNF-alpha requires AKT/GSK-3beta-mediated stabilization of snail in colorectal cancer. PLoS ONE: 1932-6203,2013.
6. G. M. Jiang, H. S. Wang, F. Zhang, K. S. Zhang, Z. C. Liu, R. Fang, H. Wang, S. H. Cai and J. Du: Histone deacetylase inhibitor induction of epithelial-mesenchymal transitions via up-regulation of Snail facilitates cancer progression. Biochimica Et Biophysica Acta-Molecular Cell Research: 0167-4889,2013.
7. R. Fang, G. Zhang, Q. Guo, F. Ning, H. Wang, S. Cai and J. Du : Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma. Cancer letters: 1872-7980,2013.
8. Y. Deng, P. Gao, C. Guo, L. Wu, J. Xu, H. Chen and S.-h. Cai: Z-GP Modification to CI-994, a Histone Deacetylase Inhibitor and the Application in Target-ing Carcinoma Chemotherapy. Medicinal Chemistry :1573-4064,2013.
9. H. Liu, B. H. Zhou, X. Qiu, H. S. Wang, F. Zhang, R. Fang, X. F. Wang, S. H. Cai, J. Du and X. Z. Bu: T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells. Free Radical Biology and Medicine: 0891-5849,2012.
10. Huang S, Fang R, Xu J, Qiu S, Zhang H, Du J, Cai S: Evaluation of the tumor targeting of a FAP alpha-based doxorubicin prodrug. J Drug Target:19(7):487-496,2011
11. Y. M. Yi, G. Zhang, J. Zeng, S. C. Huang, L. L. Li, R. Fang, G. M. Jiang, X. Z. Bu, S. H. Cai and J. Du:A new tumor vaccine FAP tau-MT elicits effective antitumor response by targeting indolamine-2,3-dioxygenase in antigen presenting cells.Cancer Biology & Therapy:1538-4047,2011.
12. J. Xu, Y. J. Lu, W. Z. Shen, H. B. Luo, S. C. Huang, J. L. Bao, S. H. Cai and Y. Q. Wang: Homology Modeling of alpha-Glucosidase and its Interactions with Andrograpolide Derivatives.Letters in Drug Design & Discovery:1570-1808,2011.
13. G. M. Jiang, Y. W. He, R. Fang, G. Zhang, J. Zeng, Y. M. Yi, S. Zhang, X. Z. Bu, S. H. Cai and J. Du: Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels.International Journal of Biochemistry & Cell Biology:1357-2725,2010.
14. Y. B. Yang, S. X. Cai, L. Yang, S. H. Yu, J. H. Jiang, X. Q. Yan, H. X. Zhang, L. Liu, Q. Liu, J. Du, S. H. Cai and K. L. P. Sung:Targeting eradication of malignant cells derived from human bone marrow mesenchymal stromal cells.Experimental Cell Research:0014-4827,2010.
15. J. Xu, S. C. Huang, H. B. Luo, G. J. Li, J. L. Bao, S. H. Cai and Y. Q. Wang:QSAR Studies on Andrographolide Derivatives as alpha-Glucosidase Inhibitors.International Journal of Molecular Sciences:1422-0067,2010.
16. S. C. Huang, R. Fang, J. Xu, S. H. Qiu, H. Zhang, J. Du and S. H. Cai: Evaluation of the tumor targeting of a FAP alpha-base d doxorubicin prodrug.Journal of Drug Targeting:1061-186X,2010.
兼任广东省药学会临床药理专业委员副主任委员、广东省药学会第十六届理事会科普与药学教育工作委员会业委副主任委员、广东省执业药师协会第二届理事会理事。