个人简历

2002年9月南京工业大学制药与生命科学学院制药工程专业学习，2006年7月获工学学士学位。2006年9月保送南京工业大学硕博连读，2011年6月获发酵工程博士学位。2011年7月至今，江南大学医药学院、药学院，先后任讲师、硕士生导师、副教授、副院长。2018年12月至今，美国伦斯勒理工大学（Rensselaer Polytechnic Institute）访问学者。

研究领域

药物中间体的生物催化与生物转化、抗生素及营养化学品的生物法合成

近期论文

[1] Li H, Wang XD, Zhou LF, Ma Y, Yuan WJ, Zhang XM, Shi JS, Xu ZH. Enhancing expression of 3-ketosteroid-9α-hydroxylase oxygenase, an enzyme with broad substrate range and high hydroxylation ability, in Mycobacterium sp. LY-1, Applied Biochemistry and Biotechnology. 2018, DOI:10.1007/s12010-018-2876-2.
[2] Sun J, Li H*, Ni Y, Zhang XM, Shi JS, Xu ZH.Genome shuffling of Colletotrichum lini for improving 3β,7α,15α-trihydroxy-5-androsten-17-one production from dehydroepiandrosterone. Journal of Industrial Microbiology and Biotechnology, 2017, 44(6):937-947.
[3] Li H, Wang XD, Ma Y, Yang NN, Zhang XJ, Xu ZH, Shi JS. Purification and characterization of a glycosidase with hydrolyzing multi-3-O-glycosides of spirostanol saponin activity from Gibberella intermedia. Journal of Molecular Catalysis B: Enzymatic, 2016, 128: 46-51.
[4] Li H, Yin SQ, Zhang XM Zhang XJ, Li H, Shi JS, Xu ZH. Enhanced 3β,7α,15α-trihydroxy-5-androsten-17-one production from dehydroepiandrosterone by Colletotrichum lini ST-1 resting cells with Tween-80. Applied Biochemistry and Biotechnology, 2016, 178(1):91-100.
[5] Li H, Fu ZZ, Zhang XM, Li H, Shi JS, Xu ZH. The efficient production of 3β,7α,15α-trihydroxy-5-androsten-17-one from dehydroepiandrosterone by Gibberella intermedia. Applied Biochemistry and Biotechnology, 2014, 174(8):2960-2971.
[6] Li H, Fu ZZ, Li H, Dou WF, Shi JS, Xu ZH. Improvement of the steroid dihydroxylation efficiency from dehydroepiandrosterone using a substrate pre-induction biotransformation process. Biotechnology and Bioprocess Engineering, 2013, 18(3):486-490.
[7] Li H, Xu H, Li S, Feng XH, Ouyang PK. Optimization of exopolysaccharide welan gum production by Alcaligenes sp. CGMCC2428 with Tween-40 using response surface methodology. Carbohydrate Polymers, 2012, 87(2):1363-1368.
[8] Su C, Gong JS, Sun YX, Qin JF, Zhai S, Li He, Li H, Lu ZM, Xu ZH, Shi JS. Combining pro-peptide engineering and multisite saturation mutagenesis to improve the catalytic potential of keratinase. ACS Synthetic Biology, 2019, 8(2): 425-433.
[9] Tao LY, Gong JS, Su C, Jiang M, Li H, Li H, Lu ZM, Xu ZH and Shi JS. Mining and Expression of a Metagenome-Derived Keratinase Responsible for Biosynthesis of Silver Nanoparticles. ACS Biomaterials Science and Engineering, 2018, 4(4):1307-1315.
[10] Zhang XJ, Liu YY, Li H, Su LL, Zhou LF, Peng J, Shen R, Zhang Y, Shi JS, Xu ZH. Microemulsion system for Colletotrichum lini ST-1 biotransformation of dehydroepiandrosterone to 7α,15α-diOH-DHEA. Biochemical Engineering Journal, 2018, 131:77-83.
[11] Li C, Li H, Sun J, Zhang XY, Shi JS, Xu ZH. Production of 7α,15α-diOH-DHEA from dehydroepiandrosterone by Colletotrichum lini ST-1 through integrating glucose-feeding with multi-step substrate addition strategy. Bioprocess and Biosystems Engineering, 2016, 39(8):1-8.
[12] Shao ML, Zhang X, Rao ZM, Xu MJ, Yang TW, Li H, Xu ZH, Yang ST. Efficient testosterone production by engineered Pichia pastoris co-expressing human 17β-hydroxysteroid dehydrogenase type 3 and Saccharomyces cerevisiae glucose 6-phosphate dehydrogenase with NADPH regeneration. Green Chemistry, 2015, 18(6):1774-1784.
[13] Wu Y, Li H, Zhang XM, Gong JS, Li H, Rao ZM, Shi JS, Xu ZH. Improvement of NADPH-dependent P450-mediated biotransformation of 7α,15α-diOH-DHEA from DHEA by a dual cosubstrate-coupled system. Steroids, 2015, 101:15-20.
[14] Wu Y, Li H, Zhang XM, Gong JS, Rao ZM, Shi S, Xu ZH. Efficient hydroxylation of functionalized steroids by Colletotrichum lini ST-1. Journal of Molecular Catalysis B: Enzymatic, 2015, 120:111-118.
[15] Shao ML, Zhang X, Rao ZM, Xu MJ, Yang TW Li H, Xu ZH. Enhanced production of androst-1, 4-Diene-3, 17-Dione by Mycobacterium neoaurum JC-12 using three-stage fermentation strategy. PLoS one, 2015, 10(9):e0137658.
[16] Li H, Fu ZZ, Li H, Zhang XM, Shi JS, Xu ZH. Enhanced biotransformation of dehydroepiandrosterone to 3β,7α,15α-trihydroxy-5-androsten-17-one with Gibberella intermedia CA3-1 by natural oils addition. Journal of Industrial Microbiology and Biotechnology, 2014, 41(10):1497-1504.