个人简历

1990/06-1993/02 美国 Wayne State University 放射肿瘤系 博士后
1984/06-1989/09 比利时 Free University of Brussels 肿瘤系 博士学位
1978/06-1982/08 复旦大学 生物系 学士学位

研究领域

功能脂肪酸等活性成分对防治和延缓前列腺癌发生机制的研究，包括脂肪合成、代谢与癌症相关关系及机制

近期论文

1. Hao D, Chen H, Hao G, Yang B, Zhang B, Zhang H, Chen W, Chen YQ. Production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus Mortierella alpina. Biotechnol Lett. 2015 Jun 25. [Epub ahead of print] PubMed PMID: 26109146.
2. Chen H, Hao G, Wang L, Wang H, Gu Z, Liu L, Zhang H, Chen W, Chen YQ. Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi. Sci Rep. 2015 Jun 10;5:11247. doi: 10.1038/srep11247. PubMed PMID: 26059272; PubMed Central PMCID: PMC4462047.
3. Mao B, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W. Metagenomic insights into the effects of fructo-oligosaccharides (FOS) on the composition of fecal microbiota in mice. J Agric Food Chem. 2015 Jan 28;63(3):856-63. doi: 10.1021/jf505156h. Epub 2015 Jan 17. PubMed PMID: 25598242.
4. Yang B, Chen H, Stanton C, Ross RP, Zhang H, et al. Review of the roles of conjugated linoleic acid in health and disease. Journal of functional foods. 2015; 15:314-325.
5. Tang X, Chen H, Chen YQ, Chen W, Garre V, Song Y, Ratledge C. Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. PLoS One. 2015 Jun 5;10(6):e0128396. doi: 10.1371/journal.pone.0128396. eCollection 2015. PubMed PMID: 26046932; PubMed Central PMCID: PMC4457416.
6. Xing J, Wang G, Zhang Q, Liu X, Gu Z, Zhang H, Chen YQ, Chen W. Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods. PLoS One. 2015 Mar 19;10(3):e0119058. doi: 10.1371/journal.pone.0119058. eCollection 2015. PubMed PMID: 25789875; PubMed Central PMCID: PMC4366247.
7. Gu Z, Shan K, Chen H, Chen YQ. n-3 Polyunsaturated Fatty Acids and Their Role in Cancer Chemoprevention. Current pharmacology reports. 2015. DOI 10.1007/s40495-015-0043-9
8. Zhang H, Zhang L, Chen H, Chen YQ, Chen W, Song Y, Ratledge C. Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expression of ATP:citrate lyase from Mus musculus. J Biotechnol. 2014 Dec 20;192 Pt A:78-84. PubMed PMID: 25450640.
9. Tang X, Zhang H, Chen H, Chen YQ, Chen W, Song Y. Effects of 20 standard amino acids on the growth, total fatty acids production, and γ-linolenic acid yield in Mucor circinelloides. Curr Microbiol. 2014 Dec;69(6):899-908. doi: 10.1007/s00284-014-0671-z. Epub 2014 Aug 13. PubMed PMID: 25117649.
10. Mao B, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W. In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7. doi: 10.1021/jf503484d. Epub 2014 Nov 3. PubMed PMID: 25340538.
11. Hao G, Chen H, Du K, Huang X, Song Y, Gu Z, Wang L, Zhang H, Chen W, Chen YQ. Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina.Biotechnol Lett. 2014 Sep;36(9):1827-34. doi: 10.1007/s10529-014-1546-x. Epub 2014 May 27. PubMed PMID: 24863290; PubMed Central PMCID: PMC4386067.
12. Yang J, Hu X, Zhang H, Chen H, Kargbo MR, Zhao J, Song Y, Chen YQ, Zhang H, Chen W. Expression, purification, and characterization of NADP+-dependent malic enzyme from the oleaginous fungus Mortierella alpina. Appl Biochem Biotechnol. 2014 Aug;173(7):1849-57. doi: 10.1007/s12010-014-0971-6. Epub 2014 May 27. PubMed PMID: 24861319.
13. Yang B, Chen H, Gu Z, Tian F, Ross RP, Stanton C, Chen YQ, Chen W, Zhang H. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. J Appl Microbiol. 2014 Aug;117(2):430-9. doi: 10.1111/jam.12524. Epub 2014 May 14. PubMed PMID: 24750362; PubMed Central PMCID: PMC4306591.
14. Zhai Q, Wang G, Zhao J, Liu X, Narbad A, Chen YQ, Zhang H, Tian F, Chen W. Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice indicate routes of protection besides intestinal sequestration. Appl Environ Microbiol. 2014 Jul;80(13):4063-71. doi: 10.1128/AEM.00762-14. Epub 2014 Apr 25. PubMed PMID: 24771031; PubMed Central PMCID: PMC4054212.
15. Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y. Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2414-22. doi: 10.1073/pnas.1315605111. Epub 2014 May 28. PubMed PMID: 24872453; PubMed Central PMCID: PMC4060669.
16. Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQ. Fatty acid synthase is required for mammary gland development and milk production during lactation. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1132-43. doi: 10.1152/ajpendo.00514.2013. Epub 2014 Mar 25. PubMed PMID: 24668799; PubMed Central PMCID: PMC4116404.
17. Hao G, Chen H, Wang L, Gu Z, Song Y, Zhang H, Chen W, Chen YQ. Role of malic enzyme during fatty acid synthesis in the oleaginous fungus Mortierella alpina. Appl Environ Microbiol. 2014 May;80(9):2672-8. doi: 10.1128/AEM.00140-14. Epub 2014 Feb 14. PubMed PMID: 24532075; PubMed Central PMCID: PMC3993310.
18. Suburu J, Lim K, Calviello G, Chen YQ. RE: Serum phospholipid fatty acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst. 2014 Apr;106(4):dju023. doi: 10.1093/jnci/dju023. Epub 2014 Mar 31. PubMed PMID: 24685923; PubMed Central PMCID: PMC4318937.
19. Zhao S, Zhang Q, Liu X, Hao G, Zhao J, et al. The protective role of glycine betaine in Lactobacillus plantarum ST-III against salt stress. Food control. 2014; 44:208-213.
20. Chen P, Zhang Q, Dang H, Liu X, Tian F, et al. Screening for potential new probiotic based on probiotic properties and alpha-glucosidase inhibitory activity. Food control. 2014; 35:65-72.