个人简历

1996-1997 年，日本大阪大学理学部高分子科学系, 联合培养博士生
1994-1999 武汉大学化学系高分子化学与物理专业, 获博士学位
1999-2000 国家中药现代化工程技术研究中心, 工程师
2000-2001 日本大阪大学蛋白质研究所, 客座研究员
2001-2005 美国北卡大学药学院, 博士后研究员
2005-2008 武汉理工大学化学工程学院制药工程系, 教授
2006-2007 美国北卡大学药学院, 访问教授
2009年至今江南大学药学院教授, 博士生导师。

研究领域

生物活性高分子、糖药物

近期论文

1. C. Deng, H. Fu, L. Teng, Z. Hu, X. Xu, J. Chen*, T. Ren, Anti-tumor activity of the regenerated triple-helical polysaccharide from Dictyophora indusiata, International Journal of Biological Macromolecules, 2013, 61, 453-458.
2. J. Chen, J. Chen, J. Song, Collagen-PVP hybrid based anti-inflammatory hydrogel for wound repairing,Journal of Controlled Release, 2013, 172: e125.
3. C. Deng, Z. Hu, H. Fu, M. Hu, X. Xu, J. Chen*, Chemical analysis and antioxidant activity in vitro of a β-D-glucan isolated from Dictyophora indusiata,International Journal of Biological Macromolecules, 2012, 51(1-2), 70-75.
4. Y. Liu, L. Liu, J. Chen, J. Li, G. Du, J. Chen, Effects of carbon sources and feeding strategies on heparosan production by Escherichia coli K5,Bioprocess and Biosystems Engineering, 2012, 35(7), 1209-1218.
5. G. Lu, L. Kai, P. Zhao, Z. Xu, C. Deng, H. Zheng, J. Huang, J. Chen*, A novel in situ-formed hydrogel wound dressing by the photocross-linking of a chitosan derivative,Wound repair and regeneration, 2010, 18(1), 70-79.
6. X. Zhang, J. Huang, P. Chang, J. Li, Y. Chen, D. Wang, J. Yu, J. Chen, Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion,Polymer, 2010, 51(19), 4398-4407.
7. P. Xu, G. Guo, J. Huang, S. Zhou, D. Wang, J. Yu, J. Chen, Alginate-based ferrofluid and magnetic microsphere thereof,International Journal of Biological Macromolecules, 2010, 47(5), 654-660.
8. J. Wang, X. Xu, H. Zheng, J. Li, C. Deng, Z. Xu, J. Chen*, Structural Characterization, Chain Conformation, and Morphology of aβ-(1→3)-D-Glucan Isolated from the Fruiting Body of Dictyophora indusiata,Journal of Agricultural and Food Chemistry, 2009, 57(13), 5918-5924.
9. K. Ling, F. Zheng, J. Li, R. Tang, J. Huang, Y. Xu, H. Zheng, J.Chen*, Effects of substitution degree of photoreactive group on the properties on the UV-fabricated chitosan scaffold,Journal of Biomedical Material Research (A), 2008, 87(1), 52-61.
10. J. Chen, J. Courtney, J. Liu, Using an enzymatic combinatorial approach to identify anticoagulant heparan structures,Chemistry and Biology, 2007, 14, 986-993.
11. J. Chen, F.Y. Avci, E.M. Munoz et. al., Enzymatic redesigning of biologically active heparan sulfate, Journal of Biological Chemistry, 2005, 280, 42817-25.
12. G. Xia, J. Chen, V. Tiwari, W. Ju et. al., Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-III binding site and an entry receptor for herpes simplex virus, type 1,Journal of Biological Chemistry,2002, 277, 37912-37919.
13. L.M McDowell，B.A. Frazier，D.R. Studelska，K. Giljum，J. Chen et. al., Inhibition or activation of apert syndrome FGFR2(S252W) signaling by specific glycosaminoglycans, Journal of Biological Chemistry, 2006, 281, 6924-6930.
14. A. Neigishi, J. Chen, D.M. MacCarty, R.J. Samulski et. al., Analysis of the interaction between adeno-associated virus and heparan sulfate using atomic force microscopy, Glycobiology, 2004, 14, 969-977.
15. J. Chen, M.B. Duncan , K. carrick, R.M. Pope et. al., Biosynthesis of 3-O-sulfotransferase heparan sulfate: unique substrate specificity of 3-O-sulfotransferase isoform 5, Glycobiology,2003, 13, 785-794.
16. J. Chen and J. Liu, Characterization of the structure of antithrombin-binding heparan sulfate generated by heparan sulfate 3-O-sulfotransferase 5, Biochim Biophys Acta, 2005, 1725, 190-200.
17. M.B. Duncan, J Chen, J.P. Krise, J. Liu, The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5, Biochim Biophys Acta, 2004, 1671, 34-43.
18. V. Tiwari, C. Clement, M.B. Duncan, J. Chen, et. al., A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1,Journal of GeneralVirology, 2004, 85, 805-809.