个人简历

教育经历
2005年-2010年，本科，东北农业大学，动物医学学院，兽医本科（5年制）。
2010年-2013年，硕士，吉林大学，动物医学学院，临床内科学，导师杨正涛教授。
2013年-2015（提前一年毕业），博士，吉林大学，动物医学学院，临床兽医学，导师张乃生教授。
2016年-至今，博士后，吉林大学，基础医学院，病原微生物，导师李凡教授。
工作经历
2015年9月-2017年9月 吉林大学动物医学学院，讲师
2017年9月-2020年 1月 吉林大学动物医学学院，副教授
2020年1月-至今 吉林大学动物医学学院，教授（破格）
2020年1月-2020年12月 国家自然科学基金委生命学部交叉融合处，兼聘
支持基金
主持国家自然基金，十三五子课题，博士后面上和特别资助等课题7项。
1. 核受体LXRa抗乳腺炎作用机制研究，国家自然基金青年基金，负责人， 2016-2018，25.2万。
2. 宠物钩端螺旋体病诊疗与防控新技术研究， 国家十三五基金子课题，负责人，2016-2020，50万。
3. 肠道菌群紊乱对血/乳屏障功能的影响，中国博士后基金一等资助， 2016-2018，8万。
4. 奶牛乳腺炎防治，吉林大学优青培育计划，2017-2019，10万。
5. 肠道菌群代谢产物短链脂肪酸对乳腺炎的保护作用，博士后特别资助，2018-2020，15万。
6. 丙酸对LPS诱导子宫内膜炎保护作用，吉林大学，2019-2021，20万。
7. 防治奶牛乳腺炎饲料添加剂研发，横向课题，2019-2021，100万。
第一作者及通讯作者在ISME journal, Br J Pharmacol, J Dairy Sci, Free Radic Biol Med, Biochem Pharmacol, J Lipid Res, J Agric Food Chem, Food Funct等杂志发表SCI论文48篇，其中ESI高被引论文1篇，累计影响因子 182，引用次数超过1000次。

研究领域

肠道（瘤胃）菌群与奶牛疾病（乳腺炎，子宫内膜炎，蹄叶炎等）；马肢蹄病研究；中性粒细胞胞外诱捕网与病原的相关研究；天然结构化合物（中药单体）、微量元素、维生素及激素等对先天免疫信号转导的影响机制。""

近期论文

The gut microbiota contributes to the development of Staphylococcus arueus-induced mastitis in mice. Hu X, Guo J, Zhao C, Cao Y, Fu Y*, Zhang N*. ISME journal. Accepted. (IF= 9.493)
Gut microbiota mediates the protective effects on endometritis induced by Staphylococcus aureus in mice. Hu X, Guo J, Zhao C, Cao Y, Fu Y*, Zhang N*. Food Funct. Accepted.
Clostridium tyrobutyricum alleviates Staphylococcus aureus-induced endometritis in mice by inhibiting endometrial barrier disruption and inflammatory response. Hu X, Guo J, Xu M, Jiang P, Yuan X, Zhao C, Maimai T, Cao Y, Zhang N, Fu Y*. Food Funct. 2019 Oct 16;10(10):6699-6710.
Targeting gut microbiota as a possible therapy for mastitis. Hu X, Li S, Fu Y*, Zhang N*. Eur J Clin Microbiol Infect Dis. 2019 May 11.
Role of Liver X Receptor in Mastitis Therapy and Regulation of Milk Fat Synthesis. Hu X, Zhang N, Fu Y*. J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):73-83.
Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating the MAPKs and Nrf2 and inhibiting the NF-κB signaling pathways. Zhao C, Jiang P, He Z, Yuan X, Guo J, Li Y, Hu X, Cao Y, Fu Y*, Zhang N*. Microb Pathog. 2019 Aug;133:103541.
Melatonin inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in lipopolysaccharide-induced endometritis in mice. Hu X, Li D, Wang J, Guo J, Li Y, Cao Y, Zhang N, Fu Y*. Int Immunopharmacol. 2018 Nov;64:101-109.
Nickel (II) nitrate hexahydrate triggered canine neutrophil extracellular traps release in vitro. Wei Z, Zhang X, Wang Y, Wang J, Fu Y*, Yang Z*. Chemosphere. 2018 Oct;208:117-121. (IF=5.108)
Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Liu B, Su K, Wang J, Wang J, Xin Z, Li F, Fu Y*. Inflammation. 2018 Oct;41(5):1640-1647.
Taraxasterol Inhibits LPS-Induced Inflammatory Response in BV2 Microglia Cells by Activating LXRα. Liu B, He Z, Wang J, Xin Z, Wang J, Li F, Fu Y*. Front Pharmacol. 2018 Apr 4;9:278.
Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells. Wang J, Xiao C, Wei Z, Wang Y, Zhang X, Fu Y*. Vet Immunol Immunopathol. 2018 Mar;197:87-92.
Platycodin D Inhibits Inflammatory Response in LPS-Stimulated Primary Rat Microglia Cells through Activating LXRα-ABCA1 Signaling Pathway. Fu Y, Xin Z, Liu B, Wang J, Wang J, Zhang X, Wang Y, Li F. Front Immunol. 2018 Jan 9;8:1929.
The formation of canine neutrophil extracellular traps induced by sodium arsenic in polymorphonuclear neutrophils. Wei Z, Zhang X, Wang J, Wang Y, Yang Z, Fu Y*. Chemosphere. 2018 Apr;196:297-302. (IF=5.108)
Costunolide protects lipopolysaccharide/d-galactosamine-induced acute liver injury in mice by inhibiting NF-κB signaling pathway. Wang Y, Zhang X, Zhao L, Shi M, Wei Z, Yang Z, Guo C, Fu Y*. J Surg Res. 2017 Dec;220:40-45.
Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide. Wang JJ, Wei ZK, Zhang X, Wang YN, Fu YH*, Yang ZT*. Br J Pharmacol. 2017 Nov;174(21):3811-3822. (IF=6.583)
Induction of heme oxygenas-1 attenuates NLRP3 inflammasome activation in lipopolysaccharide-induced mastitis in mice. Xiaoyu H, Si H, Li S, Wang W, Guo J, Li Y, Cao Y, Fu Y*, Zhang N*. Int Immunopharmacol. 2017 Nov;52:185-190.
Platycodin D suppressed LPS-induced inflammatory response by activating LXRα in LPS-stimulated primary bovine mammary epithelial cells. Wang Y, Zhang X, Wei Z, Wang J, Zhang Y, Shi M, Yang Z, Fu Y*. Eur J Pharmacol. 2017 Nov 5;814:138-143.
Propionate Protects against Lipopolysaccharide-Induced Mastitis in Mice by Restoring Blood-Milk Barrier Disruption and Suppressing Inflammatory Response. Wang J, Wei Z, Zhang X, Wang Y, Yang Z, Fu Y*. Front Immunol. 2017 Sep 15;8:1108.
Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage. Zhang Z, Li Y, Shen P, Li S, Lu X, Liu J, Cao Y, Liu B, Fu Y*, Zhang N*. Int Immunopharmacol. 2017 Aug;49:168-177.
Resveratrol inhibits LPS-induced mice mastitis through attenuating the MAPK and NF-κB signaling pathway. Zhang X, Wang Y, Xiao C, Wei Z, Wang J, Yang Z, Fu Y*. Microb Pathog. 2017 Jun;107:462-467.
Protective effect of TM6 on LPS-induced acute lung injury in mice. Hu X, Tian Y, Qu S, Cao Y, Li S, Zhang W, Zhang Z, Zhang N, Fu Y*. Sci Rep. 2017 Apr 3;7(1):572.
In Vivo Study of the Efficacy of the Essential Oil of Zanthoxylum bungeanum Pericarp in Dextran Sulfate Sodium-Induced Murine Experimental Colitis. Zhang Z, Shen P, Liu J, Gu C, Lu X, Li Y, Cao Y, Liu B, Fu Y*, Zhang N*. J Agric Food Chem. 2017 Apr 26;65(16):3311-3319. (一区)
Sodium acetate inhibits Staphylococcus aureus internalization into bovine mammary epithelial cells by inhibiting NF-κB activation. Wei Z, Xiao C, Guo C, Zhang X, Wang Y, Wang J, Yang Z, Fu Y*. Microb Pathog. 2017 Jun;107:116-121.
Sodium houttuyfonate inhibits LPS-induced inflammatory response via suppressing TLR4/NF-ĸB signaling pathway in bovine mammary epithelial cells. Wang W, Hu X, Shen P, Zhang N, Fu Y*. Microb Pathog. 2017 Jun;107:12-16.
Protective Effects of Platycodin D on Lipopolysaccharide-Induced Acute Lung Injury by Activating LXRα-ABCA1 Signaling Pathway. Hu X#, Fu Y#, Lu X, Zhang Z, Zhang W, Cao Y, Zhang N. Front Immunol. 2017 Jan 3;7:644.
Mangiferin inhibits mastitis induced by LPS via suppressing NF-ĸB and NLRP3 signaling pathways. Qu S, Wang W, Li D, Li S, Zhang L, Fu Y*, Zhang N*. Int Immunopharmacol. 2017 Feb;43:85-90.
Anti-asthmatic activity of osthole in an ovalbumin-induced asthma murine model. Wang J#, Fu Y#, Wei Z, He X, Shi M, Kou J, Zhou E, Liu W, Yang Z, Guo C. Respir Physiol Neurobiol. 2017 May;239:64-69.
Protective role of apigenin in cisplatin-induced renal injury. He X, Li C, Wei Z, Wang J, Kou J, Liu W, Shi M, Yang Z, Fu Y*. Eur J Pharmacol. 2016 Oct 15;789:215-221.
Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis. He X, Wei Z, Wang J, Kou J, Liu W, Fu Y*, Yang Z*. Sci Rep. 2016 Jun 20;6:28370. doi: 10.1038/srep28370.
Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages. Wei Z, Wang J, Shi M, Liu W, Yang Z, Fu Y*. Oncotarget. 2016 Aug 2;7(31):48995-49007.
Morin suppresses inflammatory cytokine expression by downregulation of nuclear factor-κB and mitogen-activated protein kinase (MAPK) signaling pathways in lipopolysaccharide-stimulated primary bovine mammary epithelial cells. Wang J, Guo C, Wei Z, He X, Kou J, Zhou E, Yang Z, Fu Y*. J Dairy Sci. 2016 Apr;99(4):3016-3022. (ESI高被引论文)
The anti-inflammatory effect of TR6 on LPS-induced mastitis in mice. Hu X#, Fu Y#, Tian Y, Zhang Z, Zhang W, Gao X, Lu X, Cao Y, Zhang N. Int Immunopharmacol. 2016 Jan;30:150-156.
Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts. Fu Y, Hu X, Cao Y, Zhang Z, Zhang N. Free Radic Biol Med. 2015 Dec;89:777-85. (IF=5.657)
Liver X receptor agonist prevents LPS-induced mastitis in mice. Fu Y, Tian Y, Wei Z, Liu H, Song X, Liu W, Zhang W, Wang W, Cao Y, Zhang N. Int Immunopharmacol. 2014 Oct;22(2):379-83.
Cyanidin-3-O-β-glucoside ameliorates lipopolysaccharide-induced acute lung injury by reducing TLR4 recruitment into lipid rafts. Fu Y, Zhou E, Wei Z, Wang W, Wang T, Yang Z, Zhang N. Biochem Pharmacol. 2014 Jul 15;90(2):126-34. (IF=5.091)
Cyanidin-3-O-β-glucoside inhibits lipopolysaccharide-induced inflammatory response in mouse mastitis model. Fu Y, Wei Z, Zhou E, Zhang N, Yang Z. J Lipid Res. 2014 Jun;55(6):1111-9.
Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model. Fu Y, Zhou E, Wei Z, Liang D, Wang W, Wang T, Guo M, Zhang N, Yang Z. FEBS J. 2014 Jun;281(11):2543-57.
Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. San Z#, Fu Y#, Li W, Zhou E, Li Y, Song X, Wang T, Tian Y, Wei Z, Yao M, Cao Y, Zhang N. Int Immunopharmacol. 2014 Apr;19(2):342-50.
Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-κB signaling pathway in lipopolysaccharide-induced mastitis in mice. Fu Y, Gao R, Cao Y, Guo M, Wei Z, Zhou E, Li Y, Yao M, Yang Z, Zhang N. Int Immunopharmacol. 2014 May;20(1):54-8.
Glycyrrhizin inhibits lipopolysaccharide-induced inflammatory response by reducing TLR4 recruitment into lipid rafts in RAW264.7 cells. Fu Y, Zhou E, Wei Z, Song X, Liu Z, Wang T, Wang W, Zhang N, Liu G, Yang Z. Biochim Biophys Acta. 2014 Jun;1840(6):1755-64.
Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-κB signaling pathway. Ruifeng G#, Yunhe F#, Zhengkai W, Ershun Z, Yimeng L, Minjun Y, Xiaojing S, Zhengtao Y, Naisheng Z. Eur J Pharmacol. 2014 Apr 15;729:54-8.
Staphylococcus aureus and Escherichia coli elicit different innate immune responses from bovine mammary epithelial cells. Fu Y, Zhou E, Liu Z, Li F, Liang D, Liu B, Song X, Zhao F, Fen X, Li D, Cao Y, Zhang X, Zhang N, Yang Z. Vet Immunol Immunopathol. 2013 Oct 1;155(4):245-52.
Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells. Fu Y, Liu B, Feng X, Liu Z, Liang D, Li F, Li D, Cao Y, Feng S, Zhang X, Zhang N, Yang Z. Vet Immunol Immunopathol. 2013 Jan 15;151(1-2):20-7.
Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways. Fu Y, Liu B, Zhang N, Liu Z, Liang D, Li F, Cao Y, Feng X, Zhang X, Yang Z. J Ethnopharmacol. 2013 Jan 9;145(1):193-9.
Salidroside attenuates inflammatory responses by suppressing nuclear factor-κB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice. Li D#, Fu Y#, Zhang W, Su G, Liu B, Guo M, Li F, Liang D, Liu Z, Zhang X, Cao Y, Zhang N, Yang Z. Inflamm Res. 2013 Jan;62(1):9-15.
Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Fu Y, Liu B, Liu J, Liu Z, Liang D, Li F, Li D, Cao Y, Zhang X, Zhang N, Yang Z. Int Immunopharmacol. 2012 Dec;14(4):792-8.
The effect of magnolol on the Toll-like receptor 4/nuclear factor κB signaling pathway in lipopolysaccharide-induced acute lung injury in mice. Yunhe F, Bo L, Xiaosheng F, Fengyang L, Dejie L, Zhicheng L, Depeng L, Yongguo C, Xichen Z, Naisheng Z, Zhengtao Y. Eur J Pharmacol. 2012 Aug 15;689(1-3):255-61.
Stevioside suppressed inflammatory cytokine secretion by downregulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 cells. Fengyang L, Yunhe F, Bo L, Zhicheng L, Depeng L, Dejie L, Wen Z, Yongguo C, Naisheng Z, Xichen Z, Zhengtao Y. Inflammation. 2012 Oct;35(5):1669-75.