个人简历

2017/01 -2018/01，美国明尼苏达大学，化学系，访问学者\r
2012/07 - 至今， 华中师范大学，化学学院，副教授\r
2012/07-2012/09, 日本九州大学，综合理工学府，高级访问学者\r
2008/04-2009/04，日本九州大学，综合理工学府，从事博士后研究工作\r
2008/01-2012/07，华中师范大学，化学学院，讲师\r
2002/09-2007/12，华中师范大学，化学学院，理学博士学位\r
1998/09-2002/06，山西大同大学，化学系，学士学位

研究领域

"""""1. 结合机器学习和高精度量子化学评价的共价药物从头设计理论方法的开发\r
2. 药物作用新靶标的发现，及基于靶酶结构和知识的共价/非共价药物合理设计\r
3. 活性（抑/杀藻或抗真菌活性）药物小分子的合理优化、定向合成、生物活性测试\r
4.活性分子的酶体抑制活性测试评价"

近期论文

Wen, Wuqiang; Cao, Hongxuan; Huang, Yunyuan; Tu, Jie; Wan, Chen; Wan, Jian*; Han, Xinya; Chen, Han; Liu, Jiaqi; Rao, Li; Su, Chen; Peng, Chao; Sheng, Chunquan* and Ren, Yanliang*. Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J. Med. Chem. 2022, 65, 2656-2674\r
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Han, Xinya; Huang, Yunyuan; Wei, Lin; Chen, Haifeng; Guo, Yanrong; Tang, Zilong; Hu, Wei; Xia, Qinfei; Wang, Qi; Yan, Jufen; Ren, Yanliang*. Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase. Bioorg. Med. Chem. 2020, 28, 115624\r
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Huang, Yunyuan; Xu, Yixiang; Song, Rongrong; Ni, Shuaishuai; Liu, Jiaqi; Xu, Yanhong; Ren, Yanliang*; Rao, Li; Wang, Yingjie; Wei, Lin; Feng, Lingling; Su, Chen; Peng, Chao; Li, Jian*; Wan, Jian* J. Med. Chem. 2020, 11, 6238.\r
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Wei, Lin; Wen, Wuqiang; Rao, Li; Huang, Yunyuan; Lei, Mengting; Liu, Kai; Hu, Saiya; Song, Rongrong; Ren, Yanliang*; Wan, Jian*, J. Chem. Inf. Model. 2020, 60, 4388\r
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Huang, Yunyuan; Wei, Lin; Han, Xinya; Chen, Haifeng; Ren, Yanliang*; Xu, Yanhong; Song, Rongrong; Rao, Li; Su, Chen; Peng, Chao; Feng, Lingling; Wan, Jian*, Eur. J. Med. Chem. 2019, 184, 111749.\r
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Xiao, Shan; Wei, Lin; Hong, Zongqin; Rao, Li; Ren, Yanliang*; Wan, Jian; Feng, Lingling, Bioorgan. Med. Chem. 2019, 27, 805-812.