个人简历

1999年7月毕业于华中科技大学同济医学院药理系，获得医学博士学位，2001年，在国家科技部重点实验室，全军肾病中心解放军总医院做客座研究员，师从陈香美院士，参加“973抗衰老项目”，十五攻关项目“中医对IgA肾病的辩证施治”的中药药理学研究工作,并负责中药复方拆方的药学研究工作。2002年,2009年在国家食品药品监督管理局(FSDA)新药审评中心,进行新药审评工作。被聘为湖北省药理学会治疗药物监测研究专业委员会常委、秘书长，《中国医院药学杂志》常务编委，《中国临床药理学杂志》青年编委。

研究领域

临床药代动力学、体内药物分析、心血管及肿瘤免疫药理学。

近期论文

[1] 张勇慧，微生物来源的活性天然产物的研究，药学进展，2018,42 (1):1-3. [2] Changxing Qi(#), Mengting Liu(#), Qun Zhou(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang(*), Hucheng Zhu(*), and Yonghui Zhang(*). BACE1 Inhibitory Meroterpenoids from Aspergillus terreus. Journal of Natural Products, accepted, DOI: 10.1021/acs.jnatprod.7b01050. [3] Changxing Qi, Weixi Gao, Jianping Wang, Mengting Liu, Jinwen Zhang, Chunmei Chen, Zhengxi Hu, Yongbo Xue, Dongyan Li, Qing Zhang, Yongji Lai, Qun Zhou(*), Hucheng Zhu(*), and Yonghui Zhang(*). Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophytic Aspergillus from Tripterygium wilfordii. Fitoterapia, 2018, 130, 134–139. [4] Changxing Qi(#), Qun Zhou(#), Yuan Zhou, Zengwei Luo, Chong Dai, Hucheng Zhu, Chunmei Chen, Yongbo Xue, Jianping Wang, Yafen Wang, Yaping Liu, Ming Xiang, Weiguang Sun, Jinwen Zhang(*), and Yonghui Zhang(*). Kinsenoside: A Promising Bioactive Compound from Anoectochilus Species. Current Medical science, 2018, 1, 11–18. [5] Mengting Liu(#), Weiguang Sun(#), Jianping Wang(#), Yan He, Jinwen Zhang, Fengli Li, Changxing Qi, Hucheng Zhu, Yongbo Xue, Zhengxi Hu(*)，and Yonghui Zhang(*), Bioactive secondary metabolites from the marine-associated fungus Aspergillus terreus, Bioorganic Chemistry, 2018, 80, 525-530. [6] Mengting Liu(#), Changxing Qi(#), Weiguang Sun(#), Ling Shen, Jianping Wang, Junjun Liu, Yongji Lai, Yongbo Xue, Zhengxi Hu(*) and Yonghui Zhang(*),α-Glucosidase Inhibitors from the Coral-Associated Fungus Aspergillus terreus, Frontiers in chemistry, doi: 10.3389/fchem.2018.00422 [7] Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu, Weiguang Sun(*), Zhengxi Hu(*), Yonghui Zhang(*), Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense, 2018, Marine Drugs, 16, 230. [8] Zheng-Xi Hu, Hou-Chao Xu, Kun Hu, Miao Liu, Xiao-Nian Li, Xing-Ren Li, Xue Du, Yong-Hui Zhang(*), Pema-Tenzin Puno(*), Han-Dong Sun, Structurally diverse diterpenoids from Isodon pharicus, 2018, Organic Chemistry Frontiers, 5, 2379–2389. [9] Zhengxi Hu(#), Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*), Hucheng Zhu(*), and Yonghui Zhang(*), Fusicoccane-Derived Diterpenoids from Alternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of a IKKβ Inhibitor, Organic Letters, 2018, 20, 5198–5202. [10] Huaqiang Li(#), Weiguang Sun(#), Mengyi Deng(#), Qun Zhou, Jianping Wang, Junjun Liu, Chunmei Chen, Changxing Qi, Zengwei Luo, Yongbo Xue(*), Hucheng Zhu(*), and Yonghui Zhang(*), Asperversiamides, Linearly Fused Prenylated Indole Alkaloids from the Marine-Derived Fungus Aspergillus versicolor, Journal of Organic Chemistry, 2018, 83, 8483−8492. [11] Linzhen Hu(#), Yanfei Liu(#), Yanxing Wang, Zhenzhen Wang, Jinfeng Huang, Yongbo Xue, Junjun Liu, Zhenming Liu(*), Yong Chen(*), Yonghui Zhang(*), Discovery of acylphloroglucinol-based meroterpenoid enantiomers as KSHV inhibitors from Hypericum japonicum, RSC Advances, 2018, 8, 24101. [12] Wenjing Wang, Jiaojiao Gong, Xiaorui Liu, Chong Dai, Yanyan Wang, Xiaonian Li, Jianping Wang, Zengwei Luo, Yuan Zhou, Yongbo Xue, Hucheng Zhu, Chunmei Chen(*), Yonghui Zhang(*), Cytochalasans produced by the co-culture of Aspergillus flavipes and Chaetomium globosum, Journal of Natural Products, 2018, 81, 1578–1587. [13] Huaqiang Li, Weiguang Sun, Mengyi Deng, Changxing Qi, Chunmei Chen, Hucheng Zhu, Zengwei Luo, Jianping Wang(*), Yongbo Xue(*), and Yonghui Zhang(*), Asperversins A and B, two novel meroterpenoids with an unusual 5/6/6/6 ring from the marine-derived fungus Aspergillus versicolor, Marine Drugs, 2018, 16, 177. [14] Yuben Qiao(#), Yanfei Liu(#), Xueyan Duan, Chunmei Chen, Junjun Liu, Hucheng Zhu, Yongbo Xue(*), Yonghui Zhang(*), A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala, Tetrahedron, 2018, 74, 3852-3857. [15] Zhaodi Wu, Yongji Lai, Qing Zhang, Shuangshuang Xie, Mi Zhang, Zhengxi Hu, Xiao-Nian Li, Jianping Wang, Zengwei Luo, Yongbo Xue, Qun Zhou, Hucheng Zhu, Yonghui Zhang(*), Phenylacetylene-bearing3,4-seco-cleistanthane diterpenoids from the roots of Phyllanthus glaucus, Fitoterapia, 2018, 128, 79–85. [16] Keliang Chen(#), Weiguang Sun(#), Qiong Bie, Xiulan Liu, Chunmei Chen, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo, Hucheng Zhu(*), Yonghui Zhang(*), Fusopoltide A and fusosterede A, A polyketide with a pentaleno[1,2-c]pyran ring system and A degraded steride, from the fungus Fusarium solani, Tetrahedron Letters, 2018, 59, 2679-2682. [17] Zheng-Xi Hu, Miao Liu, Wei-Guang Wang, Xiao-Nian Li, Kun Hu, Xing-Ren Li, Xue Du, Yong-Hui Zhang(*), Pema-Tenzin Puno(*), and Han-Dong Sun. 7α,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus. Journal of Natural Products 2018, 81, 106-116. [18] Qingyi Tong(#), Huijuan You(#), Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo(*), Yonghui Zhang(*), ZYH005, a novel DNA intercalator, overcomes all-transretinoic acid resistance in acute promyelocytic leukemia, Nucleic Acids Research, 2018, 7, 3284-3297. [19] Shuangshuang Xie(#), Ye Wu(#), Yuben Qiao, Yi Guo, Jianping Wang, Zhengxi Hu, Qing Zhang, Xiaonian Li, Jinfeng Huang, Qun Zhou, Zengwei Luo, Junjun Liu, Hucheng Zhu, Yongbo Xue(*), Yonghui Zhang(*), Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A, J. Nat. Prod., 2018, 81, 1311−1320. [20] Wenjing Wang, Xiao Wan, Junjun Liu, Jianping Wang, Hucheng Zhu, Chunmei Chen(*), Yonghui Zhang(*), Two New Terpenoids from Talaromyces purpurogenus, Marine Drugs, 2018,16, 150.