个人简历

张玉慧，女，教授，博士生导师。1997年于中国科学技术大学应用化学系毕业，获理学学士学位。2004年于香港大学化学系有机化学专业毕业，获哲学博士学位。2004年11月 至2006年8月为美国哈佛大学医学院微生物和分子遗传学系博士后。2006年10月至今，在华中科技大学生命科学与技术学院、武汉光电国家实验室（筹） Britton Chance生物医学光子学研究部工作。

研究领域

1、用于活细胞超分辨成像的有机荧光探针研究及其应用 2、在体神经元标记新方法研究及其应用 3、用于活细胞及组织成像的小分子荧光探针研究及其应用

近期论文

1、Cheng Gong, Xiangning Li, LinglingXu, Yu-Hui Zhang*, Target delivery of a gene into the brain using the RVG29-oligoarginine peptide, Biomaterials, 2012, 33, 3456−3463. 2、Yan Ma, Cheng Gong, Yilong Ma, Fengkai Fan, MeijieLuo, Fei Yang, Yu-Hui Zhang*, Direct cytosolic delivery of cargoes in vivo by a chimera consisting of D- and L-arginine residues, J Control Release, 2012, 162, 286−294. 3、Fengkai Fan, Si Nie, Dongmei Yang, MeijieLuo, Hua Shi, Yu-Hui Zhang*, Labeling lysosomes and tracking lysosome-dependent apoptosis with a cell-permeable activity-based probe, Bioconjugate Chem, 2012, 23, 1309−1317. 4、Yilong Ma, Dongmei Yang, Yan Ma, Yu-Hui Zhang*, Novel cell-penetrating peptides based on α-aminoxy acids, ChemBioChem, 2012, 13, 73−79. 5、Fengkai Fan, Si Nie, Eric B. Dammer, Duc M. Duong, Deng Pan, Lingyan Ping, LinhuiZhai, Junzhu Wu, Xuechuan Hong, Lingsong Qin, Ping Xu*, Yu-Hui Zhang*, Protein profiling of active cysteine cathepsins in living cells using an activity-based probe containing a cell-penetrating peptide, J Proteome Res, 2012,11, 5763−5772. 6、Deng Pan, Zhe Hu, Fengwu Qiu, Zhen-Li Huang, Yilong Ma, Yina Wang, Lingsong Qin, Zhihong Zhang, Shaoqun Zeng, Yu-Hui Zhang*, A general strategy for developing cell-permeable photo-modulatable organic fluorescent probes for live-cell super-resolution imaging, Nat Commun, 2014, 5:5573 doi: 10.1038/ncomms6573. 7、Dongjuan Chen, Fengkai Fan, Xingfu Zhao, Fei Xu, Peng Chen, Jie Wang, Lin Ban, Zhihua Liu, Xiaojun Feng, Yu-Hui Zhang*, Bi-Feng Liu*, Single cell chemical proteomics with membrane-permeable activity-based probe for identification of functional proteins in lysosome of tumors, Anal Chem, 2016, 88, 2466−2471.