个人简历

现任华中科技大学·武汉光电国家研究中心生物医学光子学功能实验室主任。 1999年同济医科大学免疫学专业毕业，获医学硕士学位。2003年华中科技大学生物医学工程专业毕业，获医学博士学位。自1999年7月，在华中科技大学生命科学与技术学院和武汉光电国家实验室工作，历任讲师（2000.7）、副教授（2004.11）、教授（2008.12）。2002年4月作为访问学者赴美国宾夕法尼亚大学医学院Dr. Britton Chance实验室进行为期一年的肿瘤代谢成像合作研究。2007年-2011年期间，曾多次访问加拿大多伦多大学/安大略癌症研究院Dr. Gang Zheng实验室，进行多肽-脂质纳米载体的合作研究。 研究方向为免疫光子学。针对免疫反应可视化研究的重大需求，发展多分子并行检测、活体靶向标记和多层次光学成像新方法，实现了活体免疫反应微环境中多细胞间相互作用、免疫细胞运动行为及其功能的动态成像研究。建立的免疫光子学新技术新方法已应用于肝脏免疫、肿瘤免疫、皮肤免疫和神经免疫的活体可视化研究。在Nature Communications、eLife、Autophagy、Angew. Chem. Int. Ed.和ACS Nano等SCI期刊上发表第一作者和通讯作者SCI论文40多篇。获授权中国发明专利 8 项、美国和欧洲发明专利各1项。《Cellular & Molecular Immunology》、《Bioconjugate Chemistry》和《生物化学与生物物理进展》等期刊的编委会委员。

研究领域

研究方向为免疫光子学。针对免疫反应可视化研究的重大需求，发展多分子并行检测、活体靶向标记和多层次光学成像新方法，实现了活体免疫反应微环境中多细胞间相互作用、免疫细胞运动行为及其功能的动态成像研究。建立的免疫光子学新技术新方法已应用于肝脏免疫、肿瘤免疫、皮肤免疫和神经免疫的活体可视化研究。

近期论文

[1] Xiang Yu, Lu Chen, Jianqiao Liu, Bolei Dai, Guoqiang Xu, Guanxin Shen, Qingming Luo*, Zhihong Zhang*. Immune Modulation of Liver Sinusoidal Endothelial Cells by Melittin Nanoparticles Suppresses Liver Metastasis. Nature Communications. 10: 574, 2019. [2] Qiaoya Lin1, Deqiang Deng1, Xianlin Song, Bolei Dai, Xiaoquan Yang, Qingming Luo*, and Zhihong Zhang*. Self-Assembled “Off/On” Nanopomegranate for In Vivo Photoacoustic and Fluorescence Imaging: Strategic Arrangement of Kupffer Cells in Mouse Hepatic Lobules. ACS Nano. 2019, 10.1021/acsnano.8b07283 [3] Zheng Liu, Fei Yang, Hao Zheng, Zhan Fan, Sha Qiao, Lei Liu, Juan Tao, Qingming Luo* & Zhihong Zhang*. Visualization of T cell-regulated monocyte clusters mediating keratinocyte death in acquired cutaneous immunity. Journal of Investigative Dermatology. 138: 1328-1337, 2018 (Cover paper) [4] Yuan Qian, Sha Qiao, Yanfeng Dai, Guoqiang Xu, Bolei Dai, Lisen Lu, Xiang Yu, Qingming Luo, and Zhihong Zhang*. Molecular-Targeted Immunotherapeutic Strategy for Melanoma via Dual-Targeting Nanoparticles Delivering Small Interfering RNA to Tumor-Associated Macrophages. ACS Nano, 11,9536-9549,2017 [5] Shuhong Qi, Hui Li, Lisen Lu, Zhongyang Qi, Lei Liu, Lu Chen, Guanxin Shen, Ling Fu, Qingming Luo*, Zhihong Zhang*. Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy. eLife, 5: e14756, 2016. [6] Honglin Jin, Yuan Qian, Yanfeng Dai, Sha Qiao, Chuan Huang, Lisen Lu, Qingming Luo, Jing Chen*, and Zhihong Zhang*. Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy. Theranostics, 6(11): 2000-2014, 2016. [7] Fei Yang, Shun Liu, Xiuli Liu, Lei Liu, Meijie Luo, Shuhong Qi, Guoqiang Xu, Sha Qiao, Xiaohua Lv, Xiangning Li, Ling Fu, Qingming Luo*, Zhihong Zhang*. In Vivo Visualization of Tumor Antigen-containing Microparticles Generated in Fluorescent-protein-elicited Immunity. Theranostics. 6(9):1453-1466, 2016. [8] Yuan Qian, Honglin Jin, Sha Qiao, Yanfeng Dai, Chuan Huang, Lisen Lu, Qingming Luo*, and Zhihong Zhang*. Targeting Dendritic Cells in Lymph Node with an Antigen Peptide-based Nanovaccine for Cancer Immunotherapy. Biomaterials. 98, 171-183, 2016. [9] Haiming Luo, Lisen Lu, Fei Yang, Liang Wang, Xiaoquan Yang, Qingming Luo, and Zhihong Zhang*. Nasopharyngeal cancer-specific therapy based on fusion peptide-functionalized lipid nanoparticles. ACS Nano, 8(5) 4334–4347, 2014. [10] Meijie Luo, Zhihong Zhang*, Hui Li, Sha Qiao, Zheng Liu, Ling Fu, Guanxin Shen, and Qingming Luo*. Multi-scale optical imaging of the delayed type hypersensitivity reaction attenuated by rapamycin. Theranostics. 4(2): 201-214, 2014. [11] Chuan Huang, Honglin Jin, Yuan Qian, Shuhong Qi, Haiming Luo, Qingming Luo, and Zhihong Zhang*. Hybrid melittin cytolytic peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo. ACS Nano, 7(7): 5791–5800, 2013. [12] Ying Zheng, Yanyan Liu, Honglin Jin, Shaotao Pan, Yuan Qian, Chuan Huang, Yixin Zeng, Qingming Luo, Musheng Zeng*, and Zhihong Zhang*. Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by HDL-mimetic nanoparticles. Theranostics. 3(7):477-486, 2013. [13] Liang Wang, Min Chen, Jie Yang, and Zhihong Zhang*. LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells. Autophagy. 9(5): 756-769, 2013. [14] Ting Su, Shaotao Pan, Qingming Luo, and Zhihong Zhang*. Monitoring of dual bio-molecular events using FRET biosensors based on mTagBFP/sfGFP and mVenus/mKOκ fluorescent protein pairs. Biosensors and Bioelectronics. 46: 97-101, 2013. [15] Haiming Luo, Jiyun Shi, Honglin Jin, Di Fan, Lisen Lu, Fan Wang*, and Zhihong Zhang*. An 125I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials. 33 (19): 4843-4850, 2012. [16] Ting Su, Zhihong Zhang*, and Qingming, Luo. Ratiometric fluorescence imaging of dual bio-molecular events in single living cells using a new FRET pair mVenus/mKOκ-based biosensor and a single fluorescent protein biosensor. Biosensors and Bioelectronics. 31(1): 292-298, 2012. [17] Haiming Luo, Jie Yang, Honglin Jin, Chuan Huang, Jianwei Fu, Fei Yang, Hui Gong, Shaoqun Zeng, Qingming Luo, and Zhihong Zhang*. Tetrameric far-red fluorescent protein as a scaffold to assemble an octavalent peptide nanoprobe for enhanced tumor targeting and intracellular uptake in vivo. FASEB Journal. 25(6): 1865-1873, 2011. [18] Jie Yang, Zhihong Zhang*, Xin A. Zhang, and Qingming Luo. A ligation-independent cloning method using nicking DNA endonuclease. BioTechniques. 49(5): 817-821, 2010. (F1000) [19] Zhihong Zhang1, Juan Chen1, Lili Ding, Honglin Jin, Jonathan F. Lovell, Ian Corbin, Weiguo Cao, Pui-Chi Lo, Mi Yang, Ming-Sound Tsao, Qingming Luo, and Gang Zheng*, HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting. Small. 6(3): 430-437, 2010. (Co-first author) [20] Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, and Gang Zheng*. Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery. Angewandte Chemie International Edition. 48(48): 9171-9175, 2009.