个人简历

工作经历 2016.12-至今 华中科技大学同济药学院 教授 2013.6至2016.12 国立新加坡大学 博士后 导师：严洁 2011.10-2013.3 东京大学 研究助理 导师：Noji, Hiroyuki 教育经历： 2001.9-2006.7 北京大学 理学学士 (生命科学) 2006.10-2008.9 大阪大学 工学硕士（生物技术） 2008.10-2012.11 大阪大学 工学博士（生物技术）

研究领域

分子药理学，单分子生物物理, 核酸的结构和功能。

近期论文

1. Tong, Q(#)., You, H(#)., Chen, X., Wang, K., Sun, W., Pei, Y., Zhao, X., Yuan, M., Zhu, H., Luo, Z(*)., Zhang, Y(*). ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia. Nucleic Acids Research. 2018, 46(7): 3284-3297. 2. You, H(#)., Guo, S(#)., Le, S., Tang, Q., Yao, M., Zhao, X., & Yan, J(*). Two-State Folding Energy Determination Based on Transition Points in Non-Equilibrium Single-Molecule Experiments. The journal of physical chemistry letters. 2018, 9 (4), pp 811–816. 3. Guo, S., Tang, Q., Yao, M., You, H., Le, S., Chen, H., & Yan, J. Structural-elastic determination of the force-dependent transition rate of biomolecules. Chemical Science. 2018, 9, 5871-5882. 4. Iino, R(#)(*)., Iida, T., Nakamura, A., You, H(*)., Saita, E., Sako, Y (*) . Single-molecule imaging and manipulation of biomolecular machines and systems. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018.2.1, 1862(2): 241~252. 5. You, H(#)(*)., Le, S(#)., Chen, H., Qin, L., & Yan, J(*). Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers. Journal of visualized experiments: JoVE, 2017 (127). 6. You H(#)., Lattmann S(#)., Rhodes, D(*)., Yan J(*). RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis. Nucleic Acids Research, 2017, 45(1): 206-214. 7. You, H(#)., Wu, J., Shao, F., & Yan, J(*). Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation. Journal of the American Chemical Society, 2015, 137 (7), 2424-2427. 8. Watanabe R(#), Koyasu K(#), You H, Tanigawara M, Noji H(*). Torque transmission mechanism via DELSEED loop of F1-ATPase. Biophysical Journal 2015, 108 (5), 1144-1152. 9. You H(#), Zeng X, Xu Y, Lim C.J, Efremov A, Phan A.T, Yan J(*). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Research 2014, 42 (13), 8789-8795. 10. You H(#), Iino R, Watanabe R, Noji H(*). Winding single-molecule double-stranded DNA on a nanometer-sized reel. Nucleic Acids Research 2012 40 (19): e151. doi: 10.1093/nar/gks651.