个人简历
教育经历： 2006/9 - 2010/6，华中科技大学协和医院，生物化学与分子生物学，博士，导师黄士昂教授 2008/1 – 2010/4,美国加州大学旧金山分校药学院（UCSF），联合培养博士研究生，导师：Chen Xin（陈昕）教授 2001/9 - 2004/6，华中农业大学生命科学院，微生物学，硕士，导师周俊初教授 工作经历： 2014/11 -至今，华中科技大学，药学院，副教授 2006/11 - 2014/11，华中科技大学，药学院，讲师 2004/7 - 2006/11，华中科技大学，药学院，助教
研究领域
实验室主要从事与肝癌相关的肿瘤发生机制以及靶向给药研究。我们希望通过研究肝癌发生的分子机制，找到可以用于肝癌治疗的靶点，并开展靶向给药研究。
近期论文
1. Qi S,Li B, Yang T,Liu Y,Cao S,He X,Zhang P,Li L,Xu C*. Validation of bmi1 as a therapeutic target of hepatocellular carcinoma in mice.Int J Mol Sci.2014 Nov 3;15(11):20004-21. doi: 10.3390/ijms151120004.IF: 2.7 2. Yang T,Li B,Qi S,Liu Y,Gai Y,Ye P,Yang G,Zhang W,Zhang P,He X,Li W,Zhang Z,Xiang G*,Xu C*.Co-delivery of doxorubicin and Bmi1 siRNA by folate receptor targeted liposomes exhibits enhanced anti-tumor effects in vitro and in vivo.Theranostics.2014 Aug 24;4(11):1096-111. doi: 10.7150/thno.9423. eCollection 2014.IF:7.8 3. Huang Y,Yang T,Zhang W,Lu Y,Ye P,Yang G,Li B,Qi S,Liu Y,He X,Lee RJ,Xu C*,Xiang G*. A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo.Int J Nanomedicine.2014 Sep 29;9:4581-95. doi: 10.2147/IJN.S69115. eCollection 2014.IF: 4.2 4. Yuanyuan Guo, Min Chu, Songwei Tan, Shuang Zhao, Hanxiao Liu, Ben Oketch Otieno, Xiangliang Yang,Chuanrui Xu*，Zhiping Zhang*.Chitosan-g-TPGS nanoparticles for anti-cancer drug delivery and overcoming multi-drug resistance.Mol Pharm.2014 Jan 6;11(1):59-70. doi: 10.1021/mp400514t. Epub 2013 Nov 21.IF: 4.8 5. Xu D,He X,Chang Y,Xu C,Jiang X,Sun S,Lin J. Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells.Oncol Rep.2012 Nov 14. doi: 10.3892/or.2012.2138. [Epub ahead of print]IF:2.2 6. Liang D,Zhou Q,Zhang J,Gong W,Xu C,Li B,Wang Y,Li J. A novel chenodeoxycholic acid-verticinone ester induces apoptosis and cell cycle arrest in HepG2 cells.Steroids.2012 Nov;77(13):1381-90. doi: 10.1016/j.steroids.2012.08.013. Epub 2012 Sep 4.IF:2.8 7. Fan L＃,Xu C＃,Wang C,Tao J,Ho C,Jiang L,Gui B,Huang S,Evert M,Calvisi DF,Chen X. Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.PLoS One.2012;7(9):e46472. doi: 10.1371/journal.pone.0046472. Epub 2012 Sep 28IF:4.4 8. Xu C＃,Lee SA,Chen X.RNA interference as therapeutics for hepatocellular carcinoma.Recent Pat Anticancer Drug Discov.2011 Jan;6(1):106-15.IF:2.6 9. Kosinski C,Stange DE,Xu C,Chan AS,Ho C,Yuen ST,Mifflin RC,Powell DW,Clevers H,Leung SY,Chen X.Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.Gastroenterology.2010 Sep;139(3):893-903IF：12.0
