个人简历

学习背景： 2014.9－2018.6 华中科技大学协和医院，博士学位 1999.9－2002.6 华中科技大学药理学系，硕士学位 1991.9－1996.6 同济医科大学临床医学系，学士学位 工作经历： 2002.7－至今 华中科技大学同济医学院附属协和医院药学部，药师、主管药师、副主任药师、主任药师 2007.2－2008.2 德国Dr. Margarete Fischer-Bosch临床药理研究所，国家公派访问学者 2014.7－2015.10 清华大学医院药事创新管理高级研修班（第八期）培训 1996.7－1999.8 华中科技大学同济医学院临床药理研究所

研究领域

临床药学、药物动力学和遗传药理学

近期论文

1. Yang T, Liu Y, Huang X, Zhang R, Yang C, Zhou J, Zhang Y, Wan J, Shi S*. Quercetin\u001E3\u001EO\u001Eβ\u001ED\u001Eglucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Mol Med Rep. 2018;18(3):2599-2612. 2. Huang Y, Hu K, Zhang S, Dong X, Yin Z, Meng R, Zhao Y, Dai X, Zhang T, Yang K, Liu L, Huang K, Shi S, Zhang Y, Chen J, Wu G, Xu S. S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics. 2018; 8(5): 1286-1300. 3. Xie J, Li Y, Jiang K, Hu K, Zhang S, Dong X, Dai X, Liu L, Zhang T, Yang K, Huang K, Chen J, Shi S, Zhang Y, Wu G, Xu S. CDK16 phosphorylates and degrades p53 to promote radioresistance and predicts prognosis in lung cancer. Theranostics. 2018;8(3):650-662. 4. Liu Y, Wu J, Li Z, Luo Y, Zeng F, Shi S*. Tolerability and pharmacokinetics of hydronidone, an antifibrotic agent for hepatic fibrosis, after single and multiple doses in healthy subjects: an open-label, randomized, dose-escalating, first-in-human study. Eur J Drug Metab Pharmacokinet. 2017;42(1):37-48 5. Liu Y, Zhou J, Luo X, Yang C, Zhang Y, Shi S*. Association of RAC1 gene polymorphisms with primary end-stage renal disease in Chinese renal recipients. PLoS One. 2016;11(2):e0148270. 6. Zhou J, Liu Y, Luo X, Shen R, Yang C, Yang T, Shi S*. Identification and association of RAC1 gene polymorphisms with mRNA and protein expression levels of Rac1 in solid organ (kidney, liver, heart) transplant recipients. Mol Med Rep. 2016;14(2): 1379-1388. 7. Xiaomei Luo, Tingyu Yang, Chunxiao Yang, Jiali Zhou, Yani Liu, Yifei Huang, Shaojun Shi*. Effects of multiple oral dosing of cyclosporine on the pharmacokinetics of quercetin in rats. Int J Clin Exp Med. 2016;9(3):5880-5890. 8. Liu Y, Luo X, Yang C, Yang T, Zhou J, Shi S*. Impact of quercetin\u001Einduced changes in drug\u001Emetabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats. Mol Med Rep. 2016;14(4):3073-3085. 9. Rufei Shen, Chunxiao Yang, Xiaomei Luo, Tingyu Yang, Jiali Zhou, Yani Liu, Shaojun Shi*. Enzyme kinetics studies of nucleoside diphosphate kinase in human erythrocytes and frequency distribution in healthy subjects and transplant recipients in Chinese Han population. Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(3):93-103. 10. Shi S, Li Y. Interplay of drug-metabolizing enzymes and transporters in drug absorption and disposition. Curr Drug Metab. 2014;15(10):915-941. 11. Shi S. Biologics: an update and challenge of their pharmacokinetics. Curr Drug Metab. 2014;15(3):271-290. 12. Liu Y, Yang C, Li Z, Zhou J, Lv Y, Zhang Y, Zeng F, Shi S*. Safety, tolerability, pharmacokinetics, and pharmacodynamics of recombinant human parathyroid hormone (1-34) in healthy Chinese subjects. Clin Ther. 2014; 36(6):940-952. 13. Li Y, Hu Y, Shi S*, Jiang L. Evaluation of antioxidant and immuno-enhancing activities of Purslane polysaccharides in gastric cancer rats. Int J Biol Macromol. 2014;68:113-116. 14. Liu Y, Li Z, Yang C, Zheng H, Lv Y, Chen H, Zhang Y, Shi S*. Tolerability and pharmacokinetics of biapenem following single and multiple intravenous administrations in healthy Chinese subjects: an open-label, randomized, single-center study. Drug Res (Stuttg). 2013;63(8):396-403. 15. Shi S, Klotz U. Drug interactions with herbal medicines. Clin Pharmacokinet. 2012;51(2):77-104. 16. Shi S, Liu Y, Li Z, Wu J, Zhou X, Zeng F. Pharmacokinetics, pharmacodynamics, and tolerability of a generic formulation of exenatide: a randomized, open-label, single- and multiple-dose study in healthy Chinese volunteers. Arzneimittelforschung. 2012;62(2):75-82. 17. Liu Y, Shi S*, Wu J, Li Z, Zhou X, Zeng F. Safety, tolerability, pharmacokinetics and pharmacodynamics of recombinant human parathyroid hormone [rhPTH(1-84)] after single- and multiple-dose subcutaneous administration in healthy Chinese volunteers. Basic Clin Pharmacol Toxicol. 2012;110(2):154-161. 18. Liu Y, Huang J, Liu J, Ma L, Lv Y, Shi S*. A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study. J Huazhong Univ Sci Technolog Med Sci. 2012;32(5):779-784.