个人简历
华中科技大学同济医学院附属协和医院药学教研室副主任，临床药学研究室副主任。国家自然科学基金审评专家，国家新药审评中心审评专家。
研究领域
临床药理 药代动力学和生物转化 药物制剂和生物效应 体内生物分析 基于代谢组学的药物不良反应机制和干预治疗
近期论文
1 Mingzhen Xu, Yang Ni, Shihong Li, Juan Du, Huqun Li, Ying Zhou, Weiyong Li, Hui Chen. Development and validation of a rapid LC–MS/MS method forsimultaneous determination of netupitant and palonosetron inhuman plasma and its application to a pharmacokinetic study. Journal of Chromatography B. 2016; 1027: 187–193. IF：2.687 2. Mingzhen Xu#, Yang Ni#, Ying Zhou, Xiaomeng He, Huqun Li, Hui Chen*, Weiyong Li*. Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects. Eur J Drug Metab Pharmacokinet. 2016; 41(5): 541-548. IF：1.68 3 Huqun Li, Maosheng Fang, Mingzhen Xu, Shihong Li, Juan Du, Weiyong Li*, Hui Chen. Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance.PLOS ONE, DOI:10.1371/journal.pone.0167930 Dec 14,2016. 4.Shihong Li, Mingzhen Xu, Huqun Li, Juan Du, Weiyong Li*. Pharmacokinetic Properties of Oral Lafutidine Tablets and the Effect of Food on its Pharmacokinetics in Healthy Chinese Subjects[J]. Advance in Therapy.DOI 10.1007/s12325-016-0383-9 5.Xu S#, Tao Z#, Hai B, Liang H, Shi Y, Wang T, Song W, Chen Y, OuYang J, Chen J, Kong F, Dong Y, Jiang SW, Li W, Wang P, Yuan Z, Wan X, Wang C, Li W, Zhang X, Chen K*. miR-424(322) reverses chemoresistance via T cell immune response activation by blocking the PD-L1 immune checkpoint. Nat Commun. 2016, 7: 11406. (IF=11.47) 6. Mingzhen Xu, Ying Zhou,Yang Ni,Xiao-Meng He, Huqun Li,Haseeb Sattar, Hui Chen, Weiyong Li*. Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intavenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers. Clinical Therapeutics, 2015, 37(11):2458-2467 7.Xiao-Meng He, Ying Zhou, Ming-Zhen Xu, Yang Li, Hu-Qun Li, Wei-Yong Li*,Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats.J Thorac Dis 2015;7(10):1725-1731. 8.Lixiu Yu, Ying Zhou, Xiaomeng He, Huqun Li, Hui Chen,Weiyong Li.Simultaneous determination of macitentan and its active metabolitein human plasma by liquid chromatography-tandem massspectrometry. Journal of Chromatography B, 1002 (2015) 358–363. 9 Mingzhen Xu, Yang Ni, Ying Zhou, Huqun Li,Hui Chen, Weiyong Li*. Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects.Eur J Drug Metab Pharmacokinet,DOI 10.1007/s13318-015-0291-4 10.Ying Zhou; Xiaomeng He; Huqun Li; Yang Ni; Mingzhen Xu; Haseeb Sattar; Hui Chen*; and Weiyong Li*,.Pharmacokinetics and Tolerability of Minodronic Acid Tablets in Healthy Chinese Subjects and Food and Age Effects on the Pharmacokinetics. Clinical Therapeutics，2015 Apr 1;37(4):869-76. (IF=2.586) 11. Ni Y, Zhou Y, Xu M, He X, Li H, Haseeb S, Chen H*, Li W*.Simultaneous determination of phentermine and topiramate in human plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study. J Pharm Biomed Anal. 2015 Jan 24;107C:444-449. doi: 10.1016/j.jpba.2015.01.035 (IF=2.829) 12.Ying ZHOU , Xiao-meng HE , Hu-qun LI , Yang NI , Ming-zhen XU , Hui CHEN *, Wei-yong LI *,Pharmacokinetics and Tissue Distribution of Clevidipine and Its Metabolite in Dogs and Rats*.J Huazhong Univ Sci Technol［Med Sci］34(6):856-860,2014.(IF=0.779) 13.Ying Zhou, Huqun Li, Xiaomeng He, Mengmeng Jia, Yang Ni, Mingzhen Xu, Hui Chen*,Weiyong Li*。Simultaneous determination of clevidipine and its primary metabolitein dog plasma by liquid chromatography–tandem mass spectrometry:Application to pharmacokinetic study。Journal of Pharmaceutical and Biomedical Analysis 100 (2014) 294–299.(IF=2.829) 14.Wang T,liu Z,Guo S,Wu L, Li M,Yang J,Chen H,Li W,Wang L,Hu Z,Zhuang Q,Xu S,Wang L,liu J,YeZ,JiJY，WangC, Chen K. The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer. Journal Oncotarget，2014 Jun 15;5(11):3611-21.(IF=6.627) 15. Mengmeng Jia, Ying Zhou, Xiao-meng He, Hui Chen∗,Weiyong Li* et al. Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. Journal of Huazhong University of Science and Technology [Medical Sciences] .34(3):431-436, 2014.(IF=0.779) 16. Ying Zhou, Jie Li, Xiaomeng He, Mengmeng Jia, Mingzhou Liu, Huqun Li, Zhengjiang Xiong, Yue Fan, Weiyong Li*. Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous determination of amlodipine, atorvastatin and its metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin in human plasma and its application in a bioequivalence study, J Pharm Biomed Anal. 2013; 83:101-7. (IF=2.947) 17. Mengmeng Jia, Jie Li, Xiaomeng He, Mingzhou Liu, Ying Zhou, Yue Fan, Weiyong Li*. Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2013; 928:52-7. (IF=2.694) 18. Xiao-meng HE, Ying Zhou, Mengmeng Jia, Jie Li, Weiyong LI*. Pharmacokinetic and Pharmacodynamic Properties of Batifiban Coadministered with Antithrombin Agents in Chinese healthyVolunteers. Journal of Huazhong University of Science and Technology (Medical sciences). 2013; 33 (5):786-790. (IF=0.779) 19. Liqiong Song, Wei Xia, Zhao Zhou, Yi Li, Jie Wei, Zhengzheng Wei, Bing Xu, Jie Shen, Weiyong Li, Shunqing Xu*. Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets. J Endocrinol, 2012; 215(2):303-11. (IF=3.548)
