个人简历

鲁友明，教授/博士研究生导师。华中科技大学同济医学院副院长/基础医学院院长、华中科技大学脑研究所所长，美国路易斯安那州立大学医学院终身bollinger教授

研究领域

长期致力于研究谷氨酸受体、离子通道在突触的生理功能和病理过程如缺血缺氧性脑病、神经退行性疾病中的作用和机制

近期论文

1.jin h, pei l, shu x, yang x, yan t, wu y, wei n, yan h, wang s, yao c, liu d, tian q, wang l,lu y. therapeutic intervention of learning and memory decays by salidroside stimulation of neurogenesis in aging.mol neurobiol.2016; 53(2):851-66.
2.pei l, shang y, jin h, wang s, wei n, yan h, wu y, yao c, wang x, zhu lq,lu y. dapk1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death.j neurosci.2014; 34(19):6546-56
3.wang x, pei l, yan h, wang z, wei n, wang s, yang x, tian q,lu y. intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke.stroke.2014; 45(10):3089-91.
4.zhao k, wen r, wang x, pei l, yang y, shang y, bazan n, zhu lq, tian q, lu y. epac inhibition of sur1 receptor increases glutamate release and seizure vulnerability.j neurosci.2013; 33(20):8861-5.
5.yang y, shu x, liu d, shang y, wu y, pei l, xu x, tian q, zhang j, qian k, wang yx, petralia rs, tu w, zhu lq, wang jz,lu y.epac null mutation impairs learning and social interactions via aberrant regulation of mir-124 and zif268 translation.neuron. 2012;73(4):774-88
6.tu w, xu x, peng l, zhong x, zhang w, soundarapandian mm, balel c, wang m, jia n, zhang w, lew f, chan sl, chen y,lu y. dapk1 interaction with nmda receptor nr2b subunits mediates brain damage in stroke.cell. 2010 ;140(2):222-34
7.kim d, frank cl, dobbin mm, tsunemoto rk, tu w, peng pl, guan js, lee bh, moy ly, giusti p, broodie n, mazitschek r, delalle i, haggarty sj, neve rl,lu y, tsai lh. deregulation of hdac1 by p25/cdk5 inneurotoxicity.neuron. 2008; 60(5): 803-17
8.peng pl, zhong x, tu w, soundarapandian mm, molner p, zhu d, lau l, liu s, liu f,lu y.adar2-dependent rna editing of ampa receptor subunit glur2 determines vulnerability of neurons in forebrain ischemia.neuron. 2006;49(5):719-33
9.liu s, lau l, wei j, zhu d, zou s, sun hs, fu y, liu f,lu y. expression of ca2+-permeable ampa receptor channels primes cell death in transient forebrain ischemia.neuron. 2004;43(1):43-55
10.zhu dy,lau l,liu sh,wei js,lu ym. activation of creb after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus.proc natl acad sci usa.2004; 101(25):9453-7
11.wang j, liu s, fu y, wang jh,lu y. cdk5 activation induces ca1 pyramidal cell death by direct phosphorylating nmda receptors.nat neurosci. 2003;6(10):1039-47
12.zhu dy, liu sh, sun hs,lu ym. expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult animal dentate gyrus.j neurosci. 2003;23(1):223-9
13.liu s, wang j, zhu d, fu y, lukowiak k,lu ym. generation of functional inhibitory neurons in the adult hippocampus.j neurosci. 2003;23(3):732-6.
14.wang j, liu s, haditsch u, tu w, cochrane k, ahmadian g, tran l, paw j, wang y, mansuy i, salter mm,lu ym. interaction of calcineurin and gabaa receptor- γ2 subunit produces long-term depression at ca1 inhibitory synapses.j neurosci. 2003; 23(3): 826-36
15.lu ym, mansuy im, kandel er, roder j. calcineurin-mediated ltd of gabaergic inhibition underlies the increased excitability of ca1 neurons associated with ltp.neuron. 2000; 26(1): 197-205
16.lu ym, roder jc, davidow j, salter mw. src activation in the induction of long-term potentiation in ca1 hippocampal neurons.science. 1998;279(5355):1363-7.