个人简历
本科毕业于沈阳药科大学日语药学专业，中国协和医科大学获得药理学硕士，美国东北大学获得有机化学硕士，美国布朗大学获得分子生物学暨生物化学博士学位，而后在霍华德休斯医学研究所/德克萨斯大学西南医学中心进行膜蛋白结构生物学的博士后研究。
研究领域
重大疾病相关蛋白质的结构生物学、基于结构的药物设计与发现、基于蛋白质结构的天然药物发现、作用靶点和机制研究。
近期论文
1. Zheng, M#; Tang, RT#; Deng, Y; Yang, KY; Chen, LX*; Li, H*. Steroids from Ganoderma sinense as new natural inhibitors of cancer-associated mutant IDH1. Bioorganic Chemistry. 2018, 79:89-97. doi.org/10.1016/j.bioorg.2018.04.016. 2. Li, ZM; Zhang, YY; Chen, LX*; Li, H*. Dietary compound luteolin inhibits pancreatic cancer growth by targeting BCL-2. Food & Function. 2018, dx.doi.org/10.1039/C8FO00033F. 3. Bao,F‡; Tang, RT‡; Cheng, L; Zhang, CY; Qiu, CY; Yuan, Ting; Chen, LX*; Li, H*. Terpenoids from Vitex trifolia and their anti‑inflammatory activities. Journal of Natural Medicines. 2018, 72:570–575. 4. Zhang, YW‡; Li, ZM‡; Min, QX‡; Abulizi, P‡; Zhang, YY; Tang, RT; Chen, LX*; Li, H*. 8-Chrysoeriol, as a potential BCL-2 inhibitor triggers apoptosis of SW1990 pancreatic cancer cells. Bioorganic Chemistry. 2018, doi: 10.1016/j.bioorg.2018.01.042. 5. Bao,F‡; Yang, KY‡; Wu, CR; Gao, SY; Wang, PH; Chen, LX*; Li, H*.New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense. Fitoterapia. 2018, 125:124-129. doi: 10.1016/j.fitote.2018.01.001 6. Wang, LQ‡; Zhu, LJ‡, Gao, SY; Bao, FY; Wang, Y; Chen, YN; Li, H*; Chen, LX*. Withanolides isolated from Nicandra physaloides protect liver cells against oxidative stress-induced damage. Journal of Functional Foods. 2018, 40: 93-101. doi.org /10.1016/j.jff.2017.10.043 7. Wu, CR; Zheng, M; Gao, SY; Luan, SS; Cheng, L; Yang, KY; Wang, LY; Li, JC; Chen, LX*; Li, H*. A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity. Oncotarget, 2017, 8(69): 113516-113530. doi: 10.18632/oncotarget.23058. 8. Zhu, L; Bao, T; Deng, Y; Li, H*; Chen, LX*. Constituents of Apium graveolens and their anti-inflammatory effects. Journal of Asian Natural Products Research, 2017, DOI: 10.1080/10286020.2017.1381687 9. Cao, J; Gao, LM; Chen, Y; Sun, W; Wang, F; Li, H*; Zhang, Y*. Citrinal B, natural 11 beta-hydroxysteroid dehydrogennase type 1 inhibitor identified from structure-based virtual screening. Fitoterapia,2017, doi: 10.1016/j.fitote.2017.09.018. 10. Gao, Y‡; Zhu, L‡; Guo, J; Yuan, T; Wang, L; Li, H*; Chen LX*. Farnesyl phenolic enantiomers as natural MTH1 inhibitors from Ganoderma sinense. Oncotarget, 2017, 8(56): 95865-95879. Doi: 10.18632/oncotarget.21430. 11. Yuan, T; Zhang, C; Qiu, C; Xia, G; Wang, F; Lin, B; Li, H*; Chen, LX*. Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production. Natural Product Research. 2017, 20:1-6. doi: 10.1080/14786419.2017.1354185. 12. Zheng, M‡; Sun, WG‡; Gao, SY‡; Luan, SS; Li, D; Chen, R; Zhang, Q; Chen, LX*; Huang, J*; Li, H*. Structure Based Discovery of Clomifene as a Potent Inhibitor of Cancer-Associated Mutant IDH1. Oncotarget, 2017, 8(27):44255-44265. doi: 10.18632/oncotarget.17464. 13. Li, W; Zheng, M; Wu, SP; Gao, S; Yang, M; Li, ZM; Min, QX; Sun,WG; Chen, LX*; Xiang, GY*; Li, H*. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. Journal of Experimental & Clinical Cancer Research, 2017, 36:58. DOI: 10.1186/s13046-017-0530-4. 14. Zheng, M#; Luan, S#; Gao，SY; Cheng, L; Hao, B; Li, J; Chen, Y; Hou, XM*; Chen, LX*; Li, H*. Proton Pump Inhibitor Ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase，Oncotarget. 2017, 8(24):39143-39153. doi: 10.18632/oncotarget.16609. 15. He, Y#; Zheng, M#; Li, Q#; Hu, ZX; Zhu, HC; Liu, J; Wang, JP; Xue, Y*; Li, H*; Zhang, Y*. Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1，Organic Chemistry Frontier，2017 , 4:1137–1144，doi.org/10.1039/C6QO00847J. 16. Wang, LQ; Wang, Y., Gao, SY; Zhu, LH; Wang, F; Li, H*; Chen, LX*. Phenolic amides with anti-Parkinson’s disease (PD) effects from Nicandra physaloides. Journal of Functional Foods. 2017, 31: 229-236. doi.org/10.1016/j.jff.2017.01.045 17. Cheng, L., Wu, C-R., Zhu, L-H., Li, H*, Chen, LX*, Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor, Bioorganic & Medicinal Chemistry Letters. 2017, 27: 1243-1246. doi:10.1016/j.bmcl.2017.01.057 18. Sun, W; Chen, X; Tong, Q; Zhu, H; He, Y; Lei, L; Xue,Y;Yao, G; Luo, Z; Wang, J; Li, H*; Zhang, YH*.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicilliumcommune. Scientific Reports. 2016,6: 26418; doi:10.1038/srep26418.
