个人简历
基因组学研究所所长福建省百人计划特聘专家福建省高校领军人才福建省高端外专团队领军人才Philipp Kapranov教授长期从事系统生物学和基因组学功能方面的研究，是人类基因组普遍转录概念的提出者之一，他的成果(“The Dark Genome”)被2010年科学杂志评为过去十年最伟大的发现之一(http://www.aaas.org/news/science-breakthroughs-2010-and-insights-decade)。Philipp Kapranov教授近年来发表国际高水平论文70余篇，包括Nature、Science 、Cell及其子刊近二十篇，在vlincRNAs、ncRNAs分子机制、表达水平、功能机制等方面取得了众多显著成果。
研究领域
1. 本实验室先前已经发现了一组和细胞多能性和癌症相关的vlincRNAs，应用系统生物学、新一代分子测序以及分子生物学方法鉴别vlincRNAs的功能特性。尤其是这类RNAs在癌症以及早期发育中的作用机制。2. 在单分子测序平台基础上研发新的技术方法，并将其应用于转录组学以及基因组学分析中，解答更多的生物难题。"1. Characterizing the class of very long intergenic non-coding (vlinc) RNAs recently discovered by us using the combination of approaches mentioned above. Specifically
近期论文
1. Xu D, Cai Y, Tang L, Han X, Gao F, Cao H, Qi F, Kapranov P. A CRISPR/Cas13-based approach demonstrates biological relevance of vlinc class of long non-coding RNAs in anticancer drug response. Sci Rep. 2020 Feb 4;10(1):1794.2. Wang C, Song J, Liu W, Yao Y, Kapranov P, Sample KM, Gajendran B, Zacksenhaus E, Hao X, Ben-David Y. FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression. Int J Oncol. 2020 Feb;56(2):430-438.3. Cao H, Salazar-García L, Gao F, Wahlestedt T, Wu CL, Han X, Cai Y, Xu D, Wang F, Tang L, Ricciardi N, Cai D, Wang H, Chin MPS, Timmons JA, Wahlestedt C, Kapranov P. Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells. Nat Commun. 2019 Dec 20;10(1):5799.4. Mouawad R, Prasad J, Thorley D, Himadewi P, Kadiyala D, Wilson N, Kapranov P, Arnosti DN. Diversification of Retinoblastoma Protein Function Associated with Cis and Trans Adaptations. Mol Biol Evol. 2019 Dec 1;36(12):2790-2804.5. Diao Y, Rahman MF, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, Zaphiropoulos PG. (2018) Identification of novel GLI1 target genes and regulatory circuits in human cancer cells. Mol Oncol. 12:1718-1734.6. Cao H, Wahlestedt C, Kapranov P. (2018) Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls. Trends Genet 34:704-721.7. St Laurent G, Vyatkin Y, Antonets D, Ri M, Qi Y, Saik O, Shtokalo D, de Hoon MJ, Kawaji H, Itoh M, Lassmann T, Arner E, Forrest AR; FANTOM consortium, Nicolas E, McCaffrey TA, Carninci P, Hayashizaki Y, Wahlestedt C, Kapranov P. (2016) Functional annotation of the vlinc class of non-coding RNAs using systems biology approach. Nucleic Acids Res. 44:3233-52. doi: 10.1093/nar/gkw162. Epub 2016 Mar 21.8. Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, St Laurent G, Ayad NG, Wahlestedt C. (2015) The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proc Natl Acad Sci U S A. 2015 112:8326-31 [Epub ahead of print]9. St Laurent G, Wahlestedt C, Kapranov P. (2015) The Landscape of long noncoding RNA classification. Trends Genet 3:239-51.10. Lazorthes S, Vallot C, Briois S, Aguirrebengoa M, Thuret JY, Laurent GS, Rougeulle C, Kapranov P, Mann C, Trouche D, Nicolas E. (2015) A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus. Nature Communications 6:5971.11. Wang Q, Dong B, Firrman J, Roberts S, Moore AR, Cao W, Diao Y, Kapranov P, Xu R, Xiao W. (2014) Efficient Production of Dual Recombinant Adeno-Associated Viral Vectors for Factor VIII Delivery. Hum Gene Ther Methods 25:261-8.12. St Laurent G, Vyatkin Y, Kapranov P. (2014) Dark matter RNA illuminates the puzzle of genome-wide association studies. BMC Medicine 12:97.13. Villegas VE, Rahman MF, Fernandez-Barrena MG, Diao Y, Liapi E, Sonkoly E, Ståhle M, Pivarcsi A, Annaratone L, Sapino A, Ramírez Clavijo S, Bürglin TR, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico ME, Zaphiropoulos PG (2014) Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1. Mol Oncol. 8(5):912-26.14. Savva YA, Jepson JE, Chang YJ, Whitaker R, Jones BC, St Laurent G, Tackett MR, Kapranov P, Jiang N, Du G, Helfand SL, Reenan RA (2013) RNA editing regulates transposon-mediated heterochromatic gene silencing. Nature Commun 4:274515. St Laurent G, Shtokalo D, Dong B, Tackett MR, Fan X, Lazorthes S, Nicolas E, Sang N, Triche TJ, McCaffrey TA, Xiao W, Kapranov P (2013) VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer. Genome Biol 14(7):R73. [Epub ahead of print].16. Dong B, Moore AR, Dai J, Roberts S, Chu K, Kapranov P, Moss B, Xiao W. (2013) A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy. Nucleic Acids Res 41(13):6609-17.17. St. Laurent G, Shtokalo D, Tackett MR, Yang Z, Vyatkin Y, Milos PM, Seilheimer B, McCaffrey TA, Kapranov P (2013) On the Importance of Small Changes in RNA Expression. Methods 63(1): 18-24. [Epub ahead of print].18. St Laurent G, Kapranov P (2013) Genomics in the assessment of a multi-component, multi-target medication in soft tissue disorders. Curr Med Res Opin 29 Suppl 2:11-4.19. St Laurent G 3rd, Shtokalo D, Tackett M, Yang Z, Eremina T, Wahlestedt C, Inchima SU, Seilheimer B, McCaffrey TA, Kapranov P. (2012) Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells. BMC Genomics 13(1):504. [Epub ahead of print]20. ENCODE Project Consortium (2012) An integrated encyclopedia of DNAelements in the human genome. Nature 489:57-74.21. ENCODE Project Consortium (2012) Landscape of transcription in human cells. Nature 489:101-8.22. Kapranov P, St. Laurent G (2012) Genomic \Philipp Kapranov教授是ENCODE、FANTOM5等国际研究合作联盟的成员，同时兼任Nature、Gene、Genome Biology、Genome Research、PNAS 、Nature Biotechnology 、Nature Genetics等著名杂志的审稿人。期刊审稿人（REVIEW ACTIVITIES）:- Nature- Gene- Genome Biology- Genome Research- PNAS- Nature Biotechnology- Nature Genetics- Nucleic Acids Research- Molecular Cancer- PLOS- BMC Genomics- Frontiers- Scientific reports期刊编辑（EDITING OF PROFESSIONAL JOURNALS）
