个人简历

福建省“闽江学者”福建省特聘教授、博导，开创了内置氧化剂脱氢偶联反应，发展了被国际同行称为的崔-吴偶联反应和崔氏烯胺酮。近五年已在JACS、Angew Chem、Chem Sci、ACS Cat、Chem Commu、Org Lett 等SCI收录杂志上发表 150 篇论文, 多篇论文被 Angew Chem, Synfact 和《有机化学》等期刊作为亮点介绍，并被 Chem Rev、Chem Soc Rev、Adv Synth & Catal等期刊以较长篇幅综合评述。成功地把有机化学与现代生物医学结合起来，分别发现一种海洋生物和水生动物粗提物具有较强的抗HBV活性和逆转肝纤维化作用；经过反复实验，已经建立了切实可行的海洋生物有效成分分离方法，并对有效成分进行了抗HBV和逆转器官纤维化测试，结果发现该有效组分具有较强的抗HBV和抗肝纤维化活性，具有广阔的开发前景和应用价值。申请专利 45 项，其中21 项发明专利已授权。曾获得河南省科技进步一等奖、教育部高等学校科学研究优秀成果二等奖、河南省教育厅科技成果一等奖、福建省青年科技奖和泉州市优秀创新人才、福建省自然科学三等奖。
承担科研项目：
1. 国家海洋公益（平台），厦门市海洋小分子药物中间体与蛋白质纳米配方创新协同中心， 500万，主持
2. 国家海洋公益（项目），海洋抗乙肝抗病毒药物研发，312.39万，主持
3. 国家自然科学基金面上项目，无外加氧化剂的C-H键官能团化反应研究， 2016.1-2019.12， 78万，主持
4. 厦门市科技局，医药中间体或天然产物中一些杂环化合物的绿色构筑，75万，主持
5. 国家863计划，2012AA020810，基因治疗关键技术及产品研发，2012.01-2014.12, 88 万，主持
6. 福建省闽江学者支持计划，10BS216，福建省特聘教授---闽江学者科研启动经费，2011.01-2013.12, 200 万，主持

研究领域

"""""主要从事C-H 官能团化反应、杂环合成和海洋药物等研究工作。"

近期论文

Iodine-Catalyzed Directed C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes, Zhang, Zhenhao; Pi, Chao; Tong, Heng; Wu, Yangjie*; Cui, Xiuling*, Org Lett. 2016, Accepted\r
\r
Iridium-Catalyzed Direct ortho-C–H Amidation of Benzaldehydes through N-Sulfonyl Imines as Mask，Yudong Li，Yadong Feng，Linhua Xu，Lianhui Wang and Xiuling Cui*，Org. Lett., 2016, 18 (19), pp 4924–4927\r
\r
C8-Selective Acylation of Quinoline N-Oxides with α-Oxocarboxylic Acids via Palladium-Catalyzed Regioselective C-H Bond Activation，Xiaopei Chen, Xiuling Cui* and Yangjie Wu*, Org Lett 2016, 3722-3725\r
\r
Access to C4-Functionalized Quinolines via Copper-Catalyzed Tandem Annulation of Alkynyl Imines with Diazo Compounds，Ruifeng Zhu, Guolin Cheng,* Chunqi Jia, Lulu Xue, and Xiuling Cui*，J Org Chem, 2016, 7539.\r
\r
Copper-Catalyzed Oxidative Amination of Quinoxalin-2(1H)-ones with Amines, Yi Li, Ming Gao, Lianhui Wang and Xiuling Cui* Org. Bioorg. Chem. 2016, 8428 cover\r
\r
Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines, Pengfei Li, Yunxiang Weng, Xianxiang Xu, Xiuling Cui*， J. Org. Chem. 2016， 81 (10), 3994–4001\r
\r
One-Pot Regiospecific Synthesis of Quinoxalines via a CH2-Extrusion Reaction, Jinhai Shen, Xiangdong Wang, Xing Lin, Zhenhui Yang, Guolin Cheng, Xiuling Cui* Org Lett, 2016, 18 (6), pp 1378–1381. Highlighted by Synfact in May 2016\r
\r
“One Pot” Approach to 8-Acylated 2-Quinolinones via Pd-Catalyzed Regioselective Acylation of Quinoline N-oxides, Xiaopei Chen, Xiuling Cui* and Yangjie Wu*, Org Lett 2016 18 (10), 2411–2414 hot article\r
\r
Biological evaluation of ferrocenyl olefins: cancer cell growth inhibition, ROS production and apoptosis activity，Aijing Sun, Junsheng Lin, Chao Pi, Ruian Xu, Xiuling Cui,* Archiv der Pharmazie，2016，349(3), 186-192\r
\r
Base-Promoted Synthesis of Multisubstituted Benzo[b][1,4]oxazepines, Jinhai Shen, Lulu Xue, Xing Lin, Guolin Cheng and Xiuling Cui*, Chem Commun. 2016, back cover, 3292-3295.\r
\r
Efficient and Selective Synthesis of (E)-Enamides via Ru(II)-Catalyzed Hydroamidation of Internal Alkynes, Changsheng Kuai, Lianhui Wang, Haoyi Cui, Jinhai Shen, Yadong Feng, Xiuling Cui* ACS Catal, 2016, 186-190\r
\r
Direct Phosphonation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions，Ming Gao, Yi Li, Lijuan Xie, Xiuling Cui*，Chem Commun, 2016,52,2846 - 2849\r
\r
Ir(III)-Catalyzed Direct C-H Sulfonylamidation of 2-Aryl-1,2,3-Triazole N-oxides with Sulfonyl Azides, Bingfeng Zhu, Xiuling Cui*, Chao Pi, Dong Chen, Yangjie Wu,* Adv Synth Catal, 2016, 326-332.\r
\r
Rhodium(III)-Catalyzed C−H Activation/Alkyne Annulation by Weak Coordination of Peresters with O−O Bond as an Internal Oxidant, Jiayu Mo, Lianhui Wang, Xiuling Cui*, Org Lett, 2015, 17, 4960-4963.\r
\r
Iridium-Catalyzed Direct C-H Sulfamidation of Arylnitrones with Sulfonyl Azides at Room Temperature，Chao Pi, Xiuling Cui*, Yangjie Wu*，J Org Chem，2015, 7333-7339 Selected as a Feature article\r
\r
Base-Promoted N-Pyridylation of Heteroarenes Using N-Propargyl Enaminones as Equivalents of Pyridine Scaffolds，Guolin Cheng,* Yunxiang Weng, Xifa Yang, and Xiuling Cui*，Org Lett, 2015, 3790-3793\r
\r
Palladium-Catalyzed Direct ortho C-O Bond Construction of Azoxybenzenes with Carboxylic Acids and Alcohols, Duo Zhang, Xiuling Cui*, Fangfang Yang, Qianqian Zhang, Yu Zhu, and Yangjie Wu* Org. Chem. Front., 2015, 2015, 2, 951 – 955\r
\r
Copper-Catalyzed Synthesis of Quinazolinones from Indoles with Amines or Ammoniums, Feng, Yadong; Li, Yudong; Cheng, Guolin; Wang, Lianhui; Cui, Xiuling,* J. Org Chem, 2015, 80 (14), pp 7099–7107\r
\r
Base Promoted Cross Dehydrogenative Coupling of Quinoline N-Oxides with 1,3-Azoles\
《有机化学》编委，《化学快报》理事、编委、有机化学委员会副主任，福建省医用化学专业委员会秘书长，福建省高校分子检测与精准医学重点实验室主任，厦门市海洋与基因工程重点实验室主任，分子药物教育部工程研究中心副主任。