个人简历

华南师范大学 研究员 / 博士生导师
生物光子学研究院 副院长
激光生命科学教育部重点实验室 主 任
广东省新型超声成像设备工程技术研发中心 主 任
国家优秀青年科学基金获得者、广东特支计划科技创新青年拔尖人才、广东省高等学校优秀青年教师（培养计划）；主要研究领域包括显微光声成像技术、光声窥镜技术及其生物医学应用与仪器开发；主持国家科技部“863”青年科学家专项、国家自然科学基金重点项目（合作）、广东省自然科学基金重点项目、广东省产学研项目等；主持研发皮肤光声显微成像仪，获国家药监局创新医疗器械认定及二类医疗器械注册许可证；发表SCI期刊论文100多篇；授权国家发明专利26项。代表性论文有Journal of the American College of Cardiology, Physical Review Letter, Small, Theranostics, Optics Letter, Appl Phys Lett等，H因子21。在光声成像技术方面曾获教育部高等学校科学研究优秀成果奖二等奖 (2013年)、广东省科学技术奖(发明类)二等奖 (2009年)、美国医学物理学会“Sylvia Sorkin Greenfield Award”奖 (2008年)、中国光学重要成果奖 (2008年)。
主要研究方向及内容
（1）光-声多模态显微成像仪器及其医学应用——首创声-光共焦中空一体化激发探测结构，开发针对不同应用和功能的光声显微成像探头，研究揭示皮肤真皮深层血管病变、口腔/宫颈早期癌变等的光声影像图谱。
（2）血管层析分辨的光声内窥镜及其医学应用——研发集微型超声单元、光纤及光学整形于一体化的内窥探测系统，与 传统超声内镜、光学内窥结合，利用深度学习准确识别及提取腔体内各层组织的血管网络图像，为研究上下消化道早期肿瘤、消化道炎症-克罗恩氏病等的图像学特征提供新方法。
（3）基于弧形线阵探测的体扫描光声成像系统及应用 ——研制双弧阵面的多元阵列超声探测器，及其匹配的多路预放、主放和 采集系统，研究空间相控、空间权重矩阵降维、模型矫正等图像处理 方法提供空间分辨率，开展乳腺、脑部及四肢等部位的体扫描成像。
（4）基于LED/LD激发的小型无线光声成像系统 ——利用LED/LD等小型脉冲光源，结合wifi无线传输技术，开发研制小型 化、无线传输的掌上光声成像仪，实现即时、在线、方便的光声影像。
专利
[1] 杨思华、王志阳、马海钢、程中文、邢达，一种同时多点激发与匹配接收的光声三维成像装置及方法，发明专利号：ZL 201710772485.X，申请日：2017-08-31；授权通知日：2020-2-24
[2] 杨思华、文学、雷鹏、邢达，一种用于光声超声血管内成像系统的快速插拔式光电耦合接头，发明专利号：ZL 201810487040.1，申请日：2018-05-21；授权公告日：2019-10-25
[3] 杨思华、程中文、马海钢、邢达，快速大视场高分辨率的光声/超声扇扫成像装置及其方法，发明专利号：ZL 201610788177.1；申请日期：2016-08-31；授权公告日：2019-06-4
[4] 杨思华、李林钢、熊科迪、邢达，一种用于光声扫描的电热式微镜的步进扫描控制装置及控制方法，发明专利号：ZL 201710004401.8，申请日期：2017-01-04；授权公告日：2019-05-07
[5] 杨思华、马海钢、邢达，一种多尺度光声显微成像装置及其方法，发明专利号：ZL 201610850278.7，申请日期：2016-09-26；授权公告日：2019-05-07
[6] 杨思华、马海钢、邢达，一种连续变焦超声探头及其变焦方法，发明专利号：ZL 201610508393.6；申请日期：2016-06-29；授权公告日：2019-02-01
[7] 杨思华、雷鹏、王聘聘、邢达，一体化的光声、超声、光声弹性内窥成像装置及其方法，发明专利号：ZL 201610298603.3，申请日：2016-05-06；授权公告日：2018-10-19
[8] 杨思华、杨芬、石玉娇、邢达, 光声定量弹性成像方法及装置，发明专利号：ZL 201510944323.0，申请日：2015-12-16；授权公告日：2018-09-11
[9] 杨思华、刘瑞桉、雷鹏、邢达，血管内光声吸收-弹性-粘性多模成像一体化内窥镜及其成像方法，发明专利号：ZL 201610795903.2；申请日：2016-08-31；授权公告日：2018-06-19
[10]杨思华、马海钢、许栋、邢达，用于光学-超声-光声多模显微成像的集成化扫描头，发明专利号：ZL201510400905.2，申请日：2015-07-09；授权公告日：2017-12-08
[11]杨思华、李林钢、熊科迪、邢达，一种组合式立体角扫描的光-声内窥成像装置及其方法，发明专利号：ZL201511026350.6，申请日：2015-12-29；授权公告日：2017-01-25
[12]杨思华、李冰冰、邢达，光声-荧光流式细胞仪，发明专利号：ZL 201210574155.5，申请日期：2012-12-26；授权公告日：2014-12-24
[13]杨思华、邢达、周求真，一种基于面阵超声探测器的快速三维光声成像系统及方法，发明专利号：ZL 201010139117.X，申请日期：2010-03-30；授权公告日：2014-12-10
[14]杨思华、陈重江、邢达，无超声换能器频带限制的光声成像装置及其检测方法，发明专利号：ZL 201210507448.3，申请日期：2012-12-04; 授权公告日：2014-11-05
[15]杨思华、张建、纪轩荣、邢达，聚焦式旋转扫描光声超声血管内窥成像装置及其成像方法，发明专利号：ZL 201210220399.5 申请日期：2012-06-28；授权公告日：2014-06-25
[16]杨思华、邢达，一种基于试剂显色差异的光声酸碱度成像方法及装置，发明专利号：ZL 200810219864.7；申请日：2008-12-11，授权公告日：2011-04-20
获奖
2020年 第九届“挑战杯”华南师范大学学生课外学术科技作品竞赛，特等奖（王巍、文学、袁砚池；指导老师：杨思华、熊科迪）
2012年 教育部高等学校科学研究优秀成果奖二等奖（排名第三）
2008年 广东省科学技术奖（发明类）二等奖 （排名第三）
2007年 美国医学物理学会“Sylvia Sorkin Greenfield Award”（排名第一）
2007年 2007中国光学重要成果奖（排名第一）
参加会议
· 第十四届全国激光技术与光电子学学术会，邀请报告. (上海, 3.17-20, 2019)
· The 11th CIOP, Invited Talk. (西安, 8.6-9, 2019)
· 2019年中国光学学会学术大会，邀请报告. (合肥, 8.9-12, 2019)
· 2019 Optoelectronics Global Conference, Invited Talk. (深圳, 10.3-6, 2019)
· 2019 Photonics Asia---生物医学光子产学研高峰论坛，执行主席. (杭州, 10.21, 2019)
· 第二届海峡两岸生物医学前沿交叉学术研讨会，邀请报告. (台湾新竹, 10.23-25, 2019)
2018年：
· 2018年光生物物理学术会议，邀请报告.（银川，7.11-13, 2018）
· PIERS 2018 Toyama，Invited Talk. (JAPAN, Toyama, August 1–4, 2018)
· 2018年生物医学工程年会, 邀请报告.（深圳，9.21-23, 2018）
· 8th Advanced Optical Methods, Invited Talk. ( 深圳, Nov. 4-7, 2018)
2017年：
· 第九届全国光学青年学术论坛, 邀请报告. (福州, 11.24-27, 2017 )
· The14th PIBM, Invited Talk. (苏 州, 9.26-28, 2017)
· The 9th CIOP, Invited Talk. (哈尔滨, 7.17-20, 2017)
· 全国生物医学工程大会, 邀请报告.（北京, 4.20-22, 2017)
· Asia Communications and Photonics Conference (ACP), Invited Talk. (广州, 11.10-13, 2017)
2016年及以前：
· The 8th CIOP, Invited Talk. (上海,7.18-20, 2016)
· Internatinoal Conference on Laser Applicatins in Life Sciences, Invited Talk (深圳,10.14-18, 2016)
· CLEO Pacific Rim 2015，邀请报告（韩国，釜山，2015.8）
· PIERS 2014, 邀请报告（广州，2014.8）
· International Conference on Laser Applications in Life，邀请报告（德国，乌尔姆，2014.7）
· 中国光学大会，邀请报告（长沙，2013.8）
· 国际生物物理和医学大会（SFM’12），大会报告（俄罗斯、萨若托夫，2012.9）
· 中国光学大会，大会报告（深圳，2011.9）
· 中国光学大会，口头报告（天津，2010.8）
· 生物医学工程高层论坛，邀请报告（上海，2010.5）

研究领域

生物医学光子学、激光医学影像、光声成像""

近期论文

Chang Lu, Kedi Xiong*, Yuanzheng Ma, Wuyu Zhang, Zhongwen Cheng, and Sihua Yang*, Electrothermal-MEMS-induced nonlinear distortion correction in photoacoustic laparoscopy, Optics Express, 28(10), 15300, 2020.
Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Kedi Xiong, and Sihua Yang*, High-speed dual-view photoacoustic imaging pen, Optics Letters, 45(7), 1599-1602, 2020.
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Wuyu Zhang, and Sihua Yang*, Switchable optical and acoustic resolution photoacoustic dermoscope dedicated into in vivo biopsy-like of human skin, Appl. Phys. Lett., 116, 073703, 2020.
Fei Yang, Zhiyang Wang, Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Ying Gu, Haixia Qiu*, Sihua Yang*, Wide-field monitoring and real-time local recording of microvascular networks on small animals with a dual-raster-scanned photoacoustic microscope, J. Biophotonics, 2020; e202000022.
Peng Lei, Xue Wen, Lei Wang, Pengfei Zhang* and Sihua Yang*, Ultrafine intravascular photoacoustic endoscope with a 0.7 mm diameter probe, Optics Letters, 44(22), 5406-5409, 2019.
Xin Wang and Sihua Yang*, Imaging of human wrist joint by a flexible-transducerbased morphological-adaptive photoacoustic tomography: a feasibility study, Chinese Optics Letters, 17(9), 091701, 2019.
Weicheng Zhang, Jiandong Li, Sihua Yang*, Real-time interleaved photoacoustic and ultrasound imaging for guiding interventional procedures, Applied Acoustics, 156, 1-6, 2019.
Xin Jin, Xinkun Wang, Kedi Xiong*, and Sihua Yang*, High-resolution and extended-depth-of-field photoacoustic endomicroscopy by scanning-domain synthesis of optical beams, Optics Express, 27(14), 19369, 2019.
Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Lan Zhang, Sihua Yang*, Miniaturized photoacoustic probe for in vivo imaging of subcutaneous microvessels within human skin, Quant. Imaging. Med. Surg., 9(5): 807-814, 2019.
Kedi Xiong, Wei Wang, Ting Guo, Zhen Yuan, and Sihua Yang*, Shape-adapting panoramic photoacoustic endomicroscopy, Optics Letters, 44(11), 2681-2684, 2019.
Xiaowan Li, Kedi Xiong*, and Sihua Yang*, Large-depth-of-field optical-resolution colorectal photoacoustic endoscope, Appl. Phys. Lett., 114, 163703, 2019.
Lei Wang, Peng Lei, Xue Wen, Pengfei Zhang, and Sihua Yang*, Tapered fiber-based intravascular photoacoustic endoscopy for high-resolution and deep-penetration imaging of lipid-rich plaque, Optics Express, 27(9), 12832, 2019.
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Kedi Xiong, and Sihua Yang*, Fast controllable confocal focus photoacoustic microscopy using a synchronous zoom opto-sono objective, Optics Letters, 44(7), 1880-1883, 2019.
Haigang Ma, Kedi Xiong, Junwei Wu, Xuanrong Ji, and Sihua Yang*, Noncontact photoacoustic angiography with an air-coupled ultrasonic transducer for evaluation of burn injury, Appl. Phys. Lett., 114, 133701, 2019.
Ruian Liu, Liangzhong Xiang, Da Xing, Jiandong Li, Huan Qin, Weicheng Zhang, and Sihua Yang*, Large depth focus-tunable photoacoustic tomography based on clinical ultrasound array transducer, Appl. Phys. Lett., 113, 141102, 2018.
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Ying Gu, Tingwei Zhang, Haixia Qiu*, and Sihua Yang*, Fast linear confocal scanning photoacoustic dermoscopy for non-invasive assessment of chromatodermatosis, Appl. Phys. Lett., 113, 083704, 2018.
Qian Wang, Yujiao Shi*, Fen Yang, and Sihua Yang*, Quantitative photoacoustic elasticity and viscosity imaging for cirrhosis detection, Appl. Phys. Lett., 112, 211902, 2018.
Kedi Xiong, Sihua Yang*, Xiaowan Li, and Da Xing, Autofocusing optical-resolution photoacoustic endoscopy, Optics Letters, 43(8), 1846-1849, 2018.
Mingjun Xu†, Peng Lei†, Jianqin Feng, Fangfang Liu, Sihua Yang* and Pengfei Zhang*, Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment, Chinese Optics Letters, 16(3), 031702, 2018.
Zhongwen Cheng, Haigang Ma, Zhiyang Wang, and Sihua Yang*, 3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging, Chinese Optics Letters, 16(8), 081701, 2018.
Jiawei Sun, Quan Zhou and Sihua Yang*, Label-free photoacoustic imaging guided sclerotherapy for vascular malformations: a feasibility study, Optics Express, 26(4), 4967-4978, 2018.
Ning Liu, Sihua Yang* and Da Xing*, Photoacoustic and hyperspectral dual-modality endoscope, Optics Letters, 43(1), 138-141, 2018.
Yujiao Shi, Sihua Yang*, Da Xing*, New insight into photoacoustic conversion efficiency by plasmon-mediated nanocaviataion: implications for precision theranostics, Nano Research, 10(8), 2800-2809, 2017.
Liewei Wen, Sihua Yang*, Junping Zhong, Quan Zhou, Da Xing*, Thermoacoustic imaging and therapy guidance based on ultra-short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles, Theranostics, 7(7):1976-1989, 2017.
Yujiao Shi, Sihua Yang*, Da Xing*, Quantifying the plasmonic nanoparticle size effect on photoacoustic conversion efficiency, Journal of Physical Chemistry C, 121(10), 5805-5811, 2017.
Haigang Ma, Sihua Yang*, Zhongwen Cheng, Da Xing*, Photoacoustic confocal dermoscope with a waterless coupling and impedance matching opto-sono probe, Optics Letters, 42(12), 2342-2345, 2017.
Dayang Jin, Fen Yang, Zhongjiang Chen, Sihua Yang*, and Da Xing, Biomechanical and morphological multi-parameter photoacoustic endoscope for identification of early esophageal disease, Applied Physics Letters, 111, 103703, 2017.
Shanshan Shang, Zhongjiang Chen, Yue Zhao, Sihua Yang* and Da Xing*, Simultaneous imaging of atherosclerotic plaque composition and structure with dualmode photoacoustic and optical coherence tomography, Optics Express, 25(2), 530-539, 2017.
Liewei Wen, Wenzheng Ding, Sihua Yang*, Da Xing*, Microwave pumped high-efficient thermoacoustic tumor therapy with single wall carbon nanotubes, Biomaterials, 75, 163-173, 2016.
Yujiao Shi，Huan Qin，Sihua Yang，Da Xing*, Thermally confined shell coating amplifies the photoacoustic conversion efficiency of nanoprobes, Nano Research, 9, 3644-3655, 2016.
Hongjiang Chen†, Sihua Yang†, Ting Zhou, Jiankun Xu, Jun Hu*, Da Xing*, Synthesis and characterization of an HSP27-targeted nanoprobe for in vivo photoacoustic imaging of early nerve injury, Nanomedicine: Nanotechnology, Biology, and Medicine, 12, 1453-1462, 2016.
Qin H, Zhao Y, Zhang J, Pan X, Yang S*, Xing D*, Inflammation-targeted gold nanorods for intravascular photoacoustic imaging detection of matrix metalloproteinase-2 (MMP2) in atherosclerotic plaques, Nanomedicine: Nanotechnology, Biology, and Medicine, 12(7), 1765-1774, 2016.
Dong Xu, Sihua Yang, Ying Wang, Ying Gu*, and Da Xing*, Noninvasive and high-resolving photoacoustic dermoscopy of human skin, Biomedical Optics Express, 7(6), 2095-2102, 2016.
Zhongjiang Chen, Sihua Yang* and Da Xing*, Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging, Opt. Lett., 41(7), 1636-1639, 2016.
Junping Zhong, Sihua Yang, Liewei Wen, Da Xing, Imaging-guided photoacoustic drug release and synergistic chemo-photoacoustic therapy with paclitaxel-containing nanoparticles, Journal of Controlled Release, 226, 77-87, 2016.
Yating Wang, Dong Xu, Sihua Yang* and Da Xing*, Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector, Biomedical Optics Express, 7(2), 279-286, 2016.
Conggui Chen, Yue Zhao, Sihua Yang* and Da Xing*, Mechanical characterization of intraluminal tissue with phase-resolved photoacoustic viscoelasticity endoscopy, Biomedical Optics Express, 6(12), 4975-4980, 2015.
Cuiyun Huang, Huan Qin, Jun Qian, Jingye Zhang, Shengyuan Zhao, Yinzhi Changyi, Bingbing Li, Jianping Zhang, Jianhua Zhu, Da Xing, Sihua Yang* and Cong Li*, Multi-parametric imaging of the invasivenesspermissive acidic microenvironment in human glioma xenografts, RSC Adv., 5, 55669, 2015.
Guo He#, Dong Xu#, Huan Qin, Sihua Yang* and Da Xing*, In vivo cell characteristic extraction and identification by photoacoustic flow cytography, Biomedical Optics Express, 6(10), 3748-3756, 2015.
Conggui Chen, Yue Zhao, Sihua Yang* and Da Xing*, Integrated mechanical and structural features for photoacoustic characterization of atherosclerosis using a quasi-continuous laser, Opt. Express, 23 (13), 17309-17315, 2015.
Xuanrong Ji, Kedi Xiong, Sihua Yang* and Da Xing*, Intravascular confocal photoacoustic endoscope with dual-element ultrasonic transducer, Opt. Express, 23 (7), 9130-9136, 2015.
Huan Qin, Ting Zhou, Sihua Yang* and Da Xing*, Fluorescence quenching nanoprobes dedicated to in vivo photoacoustic imaging and high-efficient tumor therapy in deep-seated tissue, Small, 11(22), 2675-86, 2015.
Guo He, Bingbing Li, Sihua Yang*, In vivo imaging of a single erythrocyte with high-resolution photoacoustic microscopy, Frontiers of Optoelectronics, 8(2), 122-127, 2015.
Jian Zhang, Sihua Yang*, Xuanrong Ji, Quan Zhou, Da Xing*, Characterization of lipid-rich aortic plaques by intravascular photoacoustic tomography: ex vivo and in vivo validation in a rabbit atherosclerosis model with histologic correlation, Journal of the American College of Cardiology, 64(4), 385-390, 2014.
Yue Zhao,† Sihua Yang,† Conggui Chen, and Da Xing,*, Simultaneous optical absorption and viscoelasticity imaging based on photoacoustic lock-in measurement, Optics Letters, 39(9), 2565, 2014.
Bingbing Li, Huan Qin, Sihua Yang* and Da Xing*, In vivo fast variable focus photoacoustic microscopy using an electrically tunable lens, Optics Express, 22(17), 20130, 2014.
Junping Zhong, Sihua Yang*, Contrast-enhanced photoacoustic imaging using Indocyanine Green-Containing nanoparticles, Journal of Innovative Optical Health Sciences, 7(1), 1350029, 2014.
中国光学学会生物医学光子学专委会—副主任委员、
中国医学装备协会超声装备技术分委会—常务理事、
中国生物医学工程学会—青委会委员、
广东省生物物理学会—秘书长/常务理事、
广州市仪器仪表学会—理事、
《Frontiers of Optoelectronics》—编委、
《激光生物学报》—副主编
广东省药品监督管理局医疗器械注册许可专家