陈群
近期热点
资料介绍
个人简历
1984年毕业于复旦大学激光物理专业,1991年在美国密执安州奥克兰大学生物医学专业获博士学位PhD。2002年10月被聘任为广东省激光生命重点实验室光动力学研究中心主任,博士生导师,华南师范大学A岗教授。近年来在Photochem. Photobiol,Radiat. Res.等著名杂志上发表论文几十篇,大部分被SCI系统收录。受教育经历1984/09-1988/07,复旦大学,激光物理专业,学士。1988/09-1991/06,美国,密执安州,罗切斯特,奥克兰大学,生物医学专业,哲学博士研究工作经历1984 - 1986 中国,上海市。瑞金医院。激光室。助工。1986 - 1991 美国,密执安州。奥克兰大学物理系。科研助理1990– 1993 美国,密执安州。奥克兰大学物理系。客座讲师1991 - 1993 美国,密执安州。底特律市。亨利。福特医院。放射科。光学物理实验室主任。1993 –2001 美国,科罗拉多州。丹佛市。HEALTHONE。生物医学物理试验室主任2001 - 2008 美国,科罗拉多大学康复研究中心。主任2002–现在 中国,广东,广州,华南师范大学教育部重点实验室激光生命研究所。教授科研项目1.生物光子学的基础与应用研究(IRT0829)【300万】教育部“长江学者与创新团队发展计划”项目 2009.01-2011.12 第二2.用于临床医学诊断的光声和超声双成像系统研究(30627003)【100万】国家自然科学基金委 国家自然科学基金仪器专项基金项目 2007.01-2009.12 第三3.利用化学发光实现实时监控肿瘤光动力学治疗过程的研究(30870658)【30万】国家自然科学基金委 国家自然科学基金 2009.01-2011.12 主持4.激光及超短脉冲微波激发的高效乳腺肿瘤热声分子成像和热弹冲击波治疗研究(61361160414)【110万】 国家自然科学基金委 国家自然科学基金国际(地区)合作与交流项目 2014.01-2016.12 第二5基于高分辨光声成像的蛋白质功能信息的跨层次多尺度获取与整合(2011CB910402)【567万】 科技部 国家重大科学研究“973”计划2011.1-2015.12 第二研究领域
通过生物组织的正常与异常代谢的光子学直接诊断,进行恶性肿瘤的早期诊断、癌症转移的定量描述;利用高灵敏度的发光探针与单分子标记技术结合,实现高灵敏度的快速早期病变信息诊断;肿瘤光动力治疗中的新型高效光敏剂及其机理研究;光动力学和声动力学肿瘤早期诊断技术及治疗技术研究。""近期论文
1. Shengnan Wu, Feifan Zhou,Yanchun Wei, W. R.Chen,Qun Chen, & Da Xing. Cancer Phototherapy Via Selective Photoinactivation of Respiratory Chain Oxidase to Trigger a Fatal Superoxide Anion Burst. Antioxidants & redox signaling, 2014, 20(5), 733-746. (SCI indexed, IF 8.456)2. Qingzhou Ling, Chengbo Meng,Qun Chen, Da Xing, Activated ERK/FOXM1 Pathway by Low-Power Laser Irradiation Inhibits UVB-Induced Senescence through Down-Regulating p21 Expression, J. Cell. Physiol., (2013), (SCI indexed, IF 7.3)3.Jiaxing Song,Qun Chen, Da Xing,, Enhanced apoptotic effects by downregulating Mcl-1: Evidence for the improvement of photodynamic therapy with Celecoxib, ,Volume 319, Issue 10, 10 June 2013, Pages 1491–1504.4. Huang Qin, Ting Zhou, Sihua Yang,Qun Chenand Da Xing,GdIII-gold nanorods for MRI-IVPAI dual-modality detection of macrophages in atherosclerotic plaques, Nanomedicine, in press, doi: 10.2217/NNM.12.168 (2013). (SCI indexed, IF 7.3)5.Xichao Wang,Qun Chen, Da Xing,Focal Adhesion Kinase Activates NF-_B via the ERK1/2 and p38MAPK Pathways in Amyloid-_25-35-Induced Apoptosis in PC12 Cells Journal of Alzheimer’s Disease 32,2012,77–94.(SCI IF 5.1)6. Huan Qin, Ting Zhou, Sihua Yang,Qun Chenand Da Xing GdIII-gold nanorods for MRI and PAI dual-modality detection of macrophages in atherosclerotic inflammation Future Nanomedicine,accepted,2012. (SCI indexed, IF 6.0)7. Cunguang Lou, Sihua Yang, Zhong Ji,Qun Chen, and Da Xing. Ultrashort Microwave-Induced Thermoacoustic Imaging: A Breakthrough in Excitation Efficiency and Spatial Resolution. PHYSICAL REVIEW LETTERS,109, 218101 2012. (SCI indexed, IF 7.3)8. Aiguo Zhou, Yanchun Wei, Baoyan Wu,Qun Chen, Da Xing Pyropheophorbide a and c(RGDyK) co-modified chitosan-wrapped upconversion nanoparticle for targeted near-infrared photodynamic therapy, Molecular Pharmaceutics, DOI: 10.1021/mp200590y, 2012. (SCI IF 4.5)9. Yanchun Wei,Qun Chen, Baoyan Wu, Aiguo Zhou and Da Xing.High-sensitivity in vivo imaging for tumor using spectral upconversion nanoparticle NaYF4: Yb+3, Er+3 in cooperation with microtubulin inhibitor. Nanoscale, 4, 3901 2012 .(SCI IF 5.9)10. Yanchun Wei, Jiaxing Song,Qun Chen, Da Xing, Enhancement of Photodynamic Antitumor Effect With Pro-Oxidant Ascorbate. Lasers Surg Med, 44, pp 69-75, 2012.11.Hongyou Zhao, Da Xing,Qun Chen, New insights of mitochondria reactive oxygen species generation and cell apoptosis induced by low dose photodynamic therapy European JournaL of Cancer, 47, pp 2750-2761,(2011).12.Yanchun Wei, Jiaxing Song,Qun Chen,'In vivo Detection of Chemiluminescence to Monitor Photodynamic Threshold Dose for Tumor Treatment' has been passed to our Editorial Production department. Photochem. Photobiol. Sci., Photochemical & Photobiological Sciences, 10(6), pp 1066-1071, 2011.13.Li,Yunlong, Xing, Da,Chen, Qun, Chen, Wei R Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappa B using ursolic acid International Journal of Cancer, 127(2), pp 462-473, 2010.14. Ying Yang, Da Xing, Feifan Zhou,Qun Chen,Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation, Biochem. Biophys. Res. Commun., 395, 190-195, 2010.15. Liyong Yang, Yanchun Wei, Da Xing, andQun Chen, “Increasing the Efficiency of Photodynamic Therapy by Improved Light Delivery and Oxygen Supply Using an Anticoagulant in a Solid Tumor Model Lasers in Surgery and Medicine 42:671–679,2010.16. Shiming Luo, Da Xing, Yanchun Wei,Qun Chen,“Effect of Mitochondrial Photosensitizer Photofrin on Cellular Autophagy” Journal of Cellular Physiology, Volume 224, Issue 2 (p 414-422), 2010.17. Shiming Luo,Qun Chen, Eduardo Cebollero, Da Xing“Mitochondria: One of the origins for autophagosomal membranes?” Mitochondrion 9(4),227-231,2009.18. Y. C. Wei,, D Xing, S.m. Luo (1), W. Xu ,Q. Chen“Monitoring singlet oxygen in situ with delayed chemiluminescence to deduce the effect of photodynamic therapy,” J. Biomed. Opt. 09493, 2010. 相关热点
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