何祖平
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何祖平博士,湖南师范大学医学院院长,湖南师范大学潇湘学者特聘教授,博士生导师。上海高校特聘教授(东方学者)、湖湘高层次人才聚焦工程-杰出创新人才、上海市浦江人才计划、上海市教委-上海交通大学医学院双百人计划。国家自然科学基金重点项目负责人,国家重大科学研究课题负责人,国家重点研发计划课题负责人,国家自然科学基金面上项目负责人(3项),上海市科委重点项目负责人、湖南省重大专项课题负责人。2003年7月,在中国科学院研究生院获得博士学位。留美博士后和助理教授:2004年2月至2008年2月在美国乔治城大学从事博士后研究;2008年3月至2011年2月在美国乔治城大学担任助理教授。2011年2月-2017年10为上海交通大学研究员,特聘教授,博士生导师。2016年,被评审为上海市正高三级技术岗位。曾任上海市男科学研究所所长;现任模式动物与干细胞生物学湖南省重点实验室主任。他是国家杰出青年基金项目评审专家,长江学者(讲座教授、特聘教授、青年学者)评审专家。国家创新人才推进计划(创新人才、创新团队)评审专家。国家自然科学基金重大项目、重点项目、国际合作重点项目、面上项目、青年项目的通讯评审专家和/或会议评审专家。国家优秀青年基金项目评审专家。湖南省“百人计划”会评专家。上海市自然科学奖主审专家(通讯评审、会议评审)。长期从事生殖医学、细胞生物学、分子生物学研究。其研究成果已发表或接受发表在国际著名期刊,如Nature子刊CellDeathandDifferentiation(即时IF:11.07)、StemCellReports(IF:7.338)、StemCells(IF:7.747,3篇研究论文)、MolecularTherapy-NucleicAcids(即时IF:7.05,6篇研究论文)等。已发表或接受发表SCI收录论文84篇。其中,以通讯作者或第一作者已发表或接受发表SCI收录论文71篇,合计SCI影响因子(IF)>310;IF>5论文29篇,H指数31,论文被NatureGenetics、CellStemCell等SCI引用2400多次。单篇论文最高SCI引用次数291次。担任SCI期刊Reproduction副主编、ScientificReports编委、AsianJournalofAndrology编委。获得2018年度上海医学科技奖一等奖、教育部科技进步奖二等奖。近期论文
1.MinSun,QingqingYuan,MinghuiNiu,HongWang,LipingWen,ChenchengYao,JingmeiHou,ZhengChen,HongyongFu,FanZhou,ChongLi,ShaorongGao,Wei-QiangGao,ZhengLi,ZupingHe*.EfficientGenerationofFunctionalHaploidSpermatidsFromHumanGermlineStemCellsbyThree-DimensionalInducedSystem.CellDeathandDifferentiation,2018,25:747-764.即时IF:11.072.HongyongFu#,WenhuiZhang,QingqingYuan,MinghuiNiu,FanZhou,QianqianQiu,GuopingMao,HongWang,LipingWen,MinSun,ZhengLi,ZupingHe*.PAK1PromotestheProliferationandInhibitsApoptosisofHumanSpermatogonialStemCellsviaPDK1/KDR/ZNF367andERK1/2andAKTPathways.MolecularTherapy-NucleicAcid,2018,12:769-786.即时IF:7.053.HongyongFu,FanZhou,QingqingYuan,WenhuiZhang,QianqianQiu,XingYu,ZupingHe*.MiRNA-31-5pMediatestheProliferationandApoptosisofHumanSpermatogonialStemCellsviaTargetingJAZF1andCyclinA2.MolecularTherapy-NucleicAcid,2018,14:90-100.即时IF:7.054.FanZhou,QingqingYuan,WenhuiZhang,MinghuiNiu,HongyongFu,QainqianQiu,GuipingMao,HongWang,LipingWen,MujunLu,ZhengLi,ZupingHe*.MiR-663aStimulatesProliferationandSuppressesEarlyApoptosisofHumanSpermatogonialStemCellsbyTargetingNFIXandRegulatingCellCycle.MolecularTherapy-NucleicAcid,2018,12:319-336.即时IF:7.055.ChenchengYao,QingqingYuan,MinghuiNiu,HongyongFu,FanZhou,WenhuiZhang,HongWang,LipingWen,LigangWu,ZhengLi*,ZupingHe*.DistinctexpressionprofilesandnoveltargetsofmicroRNAsinhumanspermatogonia,pachytenespermatocytesandroundspermatidsbetweenOApatientsandNOApatients.MolecularTherapy-NucleicAcids,2017,9:182-194.即时IF:7.056.HongWang,QingqingYuan,MinghuiNiu,WnihuiZhang,LipingWen,HongyongFu,FanZhou,ZupingHe*.TranscriptionalregulationofP63ontheapoptosisofmalegermcellsandthreestagesofspermatogenesisinmice.CellDeathandDisease,2018,9(2):76.即时IF:6.417.RuiZhou,JingrouziWu,BangLiu,YiqunJiang,WeiChen,JianLi,QuanyuanHe,ZupingHe*.TherolesandmechanismsofLeydigcellsandmyoidcellsinregulatingspermatogenesis.CellularandMolecularLifeSciences,2019,76,2681-2696.IF:7.0148.QianqianQiu,XingYu,ChenchengYao,YujunHao,LiqingFan,ChunyiLi,PengXu,GengAn,ZhengLi,ZupingHe*.FOXP3pathogenicvariantscausemaleinfertilitythroughaffectingtheproliferationandapoptosisofhumanspermatogonialstemcells.Aging,2019,11(24):12581-12599.IF:5.519.HaoYang,YangLiu,YananHai,YuehuaGong,YingGuo,ShiYang,ZhenzhenZhang,LinhongLiu,ZhengLi,Wei-QiangGao,ZupingHe*.EfficientconversionofmousespermatogonialstemcellstophenotypicandfunctionaldopaminergicneuronsviaPI3K/AktandP21/Smurf2/Nolz1pathway.MolecularNeurobiology,2015,52(3):1654-1669.IF:6.1910.ShiYang,PingPing,MengMa,PengLi,RuhuiTian,HaoYang,YangLiu,YuehuaGong,ZhenzhenZhang,ZhengLi*,ZupingHe*.Generationofhaploidspermatidswithfertilizationanddevelopmentcapacityfromhumanspermatogonialstemcellsofcryptorchidpatients.StemCellReport,2014,3(4):663-675.IF:7.33811.YananHai,YunLiu,JingmeiHou,ZhenChen,ZupingHe*.TherolesandregulationofSertolicellsinspermatogenesis.SeminarsinCellandDevelopmentalBiology,2014,29:66-75.IF:6.26512.MengMa,ShiYang,ZhenzhenZhang,PengLi,YuehuaGong,LinhongLiu,YongZhu,RuhuiTian,YufeiLiu,XiaoboWang,FengLiu,LinHe,YangLiu,HaoYang,ZhengLi,ZupingHe*.Sertolicellsfromnon-obstructiveazoospermiaandobstructiveazoospermiapatientsshowdistinctmorphology,ramanspectrumandbiochemicalphenotype.HumanReproduction,2013,28(7):1863-1673.IF:5.0213.ChaoYang,ChenchengYao,RuhuiTian,ZijueZhu,LiangyuZhao,PengLi,HuixingChen,YuhuaHuang,ErleiZhi,YuehuaGong,YunjingXue,HongWang,QingqingYuan,ZupingHe*,ZhengLi*.miR-202-3pRegulatesSertoliCellProliferation,SynthesisFunction,andApoptosisbyTargetingLRP6andCyclinD1ofWnt/β-CateninSignaling.MolecularTherapy-NucleicAcids,2018,14:1-19.即时IF:7.0514.YingGuo,YananHai,ChenchengYao,ZhengChen,JingmeiHou,ZhengLi,ZupingHe*.Long-termcultureandsignificantexpansionofhumanSertolicellswhilstmaintainingstableglobalphenotypeandAKTandSMAD1/5activation.CellCommunicationandSignaling,2015,13:20.IF:5.32415.ZhenzhenZhang,YuehuaGong,YingGuo,YananHai,HaoYang,ShiYang,YangLiu,MengMa,LinhongLiu,ZhengLi,Wei-QiangGao,ZupingHe*.Directtransdifferentiationofspermatogonialstemcellstomorphological,phenotypicandfunctionalhepatocyte-likecellsviatheERK1/2andSmad2/3signaling,pathwaysandtheinactivationofcyclinA,cyclinBandcyclinE.CellSignalingandCommunications,2013,11:67.IF:5.32416.ZupingHe#,JijiJiang,MariaKokkinaki,LinTang,WenxianZeng,IanGallicano,InaDobrinski,MartinDym.MiRNA-20andMiRNA-106aRegulateSpermatogonialStemCellRenewalatthePost-TranscriptionalLevelviaTargetingSTAT3andCcnd12.StemCells,2013,31(10):2205~2217.IF:7.7417.ZupingHe#,JijiJiang,MariaKokkinaki,MartinDym.Nodalsignalingviaanautocrinepathwayisrequiredforproliferationofmousespermatogonialstem/progenitorcellsthroughsmad2/3andOct-4activation.StemCells,2009,27:2580-2590.IF:7.7418.ZupingHe#,JijiJiang,MariaKokkinaki,NadyGolestaneh,Marie-ClaudeHofmann,MartinDym.Gdnfupregulatesc-FostranscriptionviatheRas/Erk1/2pathwaytopromotemousespermatogonialstemcellproliferation.StemCells,2008,26:266-278.IF:7.741.曾任上海市男科学研究所所长2.模式动物与干细胞生物学湖南省重点实验室主任3.曾任上海市生殖医学重点实验室副主任4.再生医学教育部重点实验室学术委员会委员5.上海市生殖医学重点实验室学术委员会委员6.分子流行病学湖南省重点实验室学术委员会委员7.危重医学代谢组学湖南省重点实验室学术委员会副主任8.中国生理学学会生殖科学专业委员会委员9.中国动物学会生殖生物学分会理事10.国际生殖研究学会(SSR)成员委员会委员11.湖南医学会医学教育委员会副主任委员12.Reproduction副主编13.ScientificReports编委14.AsianJournalofAndrology编委 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