个人简历

学习与工作经历
1982,09－1986,07 吉林大学化学系，有机化学专业理学学士学位。
1986,09－1989,07 吉林大学理论化学研究所、物理化学理学硕士学位。导师：裘祖文教授。
1989,07－1992,07 河南师范大学化学系，助教。
1992,07－1994,11 河南师范大学化学系，讲师。
1994,11－1999,11 河南师范大学化学系，副教授。
1999,09－至今 河南师范大学化学与环境科学学院，教授。
1999,09－2002,07 北京大学药学院，天然药物与仿生药物国家重点实验室, 药物化学专业理学博士学位。导师：张礼和院士。
2003,01―2003,07 美国俄亥俄州立大学生物学院生物化学系，博士后研究员。
2003,07―2006,01 美国俄亥俄州立大学生物学院生物化学系，高级研究员。
2006,01―至今 河南师范大学化学化工学院，教授、河南省特聘教授、博士生导师。
主讲课程：
有机合成化学、糖及核苷化学、有及药物化学专论
近年来主持的主要科研项目：
1. 国家教育部“长江学者和创新团队发展计划”(IRT1061)：创新药物及医药材料的设计与合成, 2011-2013。
2. 国家自然科学基金项目(21172056)：手性羟烷基蒽醌糖苷的设计、合成及生物活性研究, 2012-2015。
3. 河南省科技创新杰出人才计划：手性药物Plavix合成关键技术及应用, 2013-2015。
4. 国家自然科学基金项目(20672031)：稀有糖及蒽环类抗生素简单结构类似物的合成及抗肿瘤活性研究, 2007-2009。
5. 国家自然科学基金项目(20872029)：新型蒽环类抗肿瘤先导物的水溶性糖基衍生物的合成及药物活性研究, 2009-2011。
6. 河南省杰出青年基金项目(084100510002)：新型蒽环类抗癌药物的合成及药物活性研究, 2008-2010。
7. 河南省高校科技创新研究团队支持计划(2008IRTSTHN002)：药物分子设计、合成及活性研究, 2008-2010。
8. 河南省高校新世纪优秀人才支持计划(2006HANCET-06)：含糖结构的抗肿瘤、抗病毒药物的设计、合成与生物活性研究, 2007-2009。

研究领域

""1. 含糖药物的新药设计与合成
2. 有机合成化学，绿色有机合成
3. 药物研发及药物生产新工艺研究""""

近期论文

Kai Sun, Guofeng Li, Yuyang Li, Jie Yu, Qing Zhao, Zhiguo Zhang, Guisheng Zhang, Oxidative Radical Relay Functionalization for the Synthesis of Benzimidazo[2,1-a]iso-quinolin-6(5H)-ones,Adv. Synth. Catal.,2020,362, 1947-1954.\r
\r
QingfengLiu,Tong-XinLiu,JinliangMa,GuishengZhang,Palladium-Catalyzed Three-Component Tandem Coupling-Carboannulation Reaction Leading to Polysubstituted [60]Fullerene-Fused Cyclopentanes,Org. Lett.,2020,22, 284-289.\r
\r
Weiwei Ma,Jingjing Bi,Chuanfang Zhao,Zhiguo Zhang,Tongxin Liu,GuishengZhang,Synthesis and biological activities of amino acids functionalized alpha-GalCer analogues,Bioorg. Med. Chem.,2020, 28,\r
\r
Guo-Jiang Mao,Zhen-Zhen Liang,Guang-Qi Gao,Ying-Ying Wang, Xin-Yu Guo,Li Su,Hua Zhang,Qiu-Juan Ma,Guisheng Zhang,A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke,Anal Chim. Acta,2019,1092, 117-125.\r
\r
Qingfeng Liu, Tong-Xin Liu, Yifei Ru, Xue Zhu,Guisheng Zhang,Palladium-catalyzed decarboxylative heterocyclizations of [60]fullerene: preparation of novel vinyl-substituted [60]fullerene-fusedtetrahydrofurans/pyrans/quinolines,Chem. Commun.,2019,55, 14498-14501.\r
\r
Nana Ma,Mingyue Lv,Tongxin Liu,Mengxiao Song,Yan Liu,Guisheng Zhang,Second-order nonlinear optical properties of [60]fullerene-fused dihydrocarboline derivates: a theoretical study on switch effect,J. Mater. Chem. C,2019,7, 13052-13058.\r
\r
Guo-Jiang Mao,Guang-Qi Gao,Zhen-Zhen Liang,Ying-Ying Wang,Li Su,Zhuo-Xi Wang,Hua Zhang, Qiu-Juan Ma,Guisheng Zhang,A mitochondria-targetable two-photon fluorescent probe with a far-red to near-infrared emission for sensing hypochlorite in biosystems,Anal Chim. Acta,2019,1081, 184-192.\r
\r
Zhiguo Zhang, Xiang Li,Mengmeng Song,Yameng Wang,Dan Zheng,Guisheng Zhang,Gong Chen,Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation,J. Org. Chem.,2019,84, 12792-12799.\r
\r
Tong-Xin Liu,Juan Wei,Pengling Zhang,Yifei Ru,Jinliang Ma,Xingjie Zhang,Nana Ma, Guisheng Zhang,Copper-Catalyzed N-H/C-H Sequential Relay Oxidative Radical Carboannulation: Construction of Diversely Substituted [60]Fullerene-FusedTetrahydrocyclopenta[b]indoles,Org. Lett.,2019,21, 6461-6465.\r
\r
Anlian Zhu,Xiaofang Xing,Shilei Wang,Donghe Yuan,Gongming Zhu, Mingwei Geng,Yuanyang Guo,Guisheng Zhang,Lingjun Li,Multi-component syntheses of diverse 5-fluoroalkyl-1,2,3-triazoles facilitated by air oxidation and copper catalysis,Green Chem.,2019,21, 3407-3412.\r
\r
Qingfeng Liu,Tong-Xin Liu,Nana Ma,Chenhao Tu,Ruoya Wang,Guisheng Zhang,Cu(II)/Mn(III)-Promoted Synergistic Radical N-Heteroannulation Reaction: Synthesis of [60]Fullerene-Fused Tetrahydroquinoline Derivatives,J. Org. Chem.,2019,84, 7255-7264.\r
\r
Zhiguo Zhang,Songnan Wang,Yong Zhang,Guisheng Zhang,Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors,J. Org. Chem.,2019,84, 3919-3926.\r
\r
Xiaopeng Zhang, Zhengwei Li, Qianqian Ding,Xiaochuan Li,Xuesen Fan, Guisheng Zhang,Alkylamino-Directed One-Pot Reaction of N-Alkyl Anilines with CO, Amines and Aldehydes Leading to 2,3-Dihydroquinazolin-4(1H)-ones,Adv. Synth. Catal.,2019,361, 976-982.\r
\r
Guo-Jiang Mao,Zhen-Zhen Liang,Jingjing Bi,Hua Zhang,Hong-Min Meng,Li Su,Yi-Jun Gong,Suling Feng,Guisheng Zhang,A near-infrared fluorescent probe based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatoryresponse,Anal Chim. Acta,2019,1048, 143-153.\r
\r
Yameng Wan,Zhiguo Zhang,Nana Ma,Jingjing Bi,Guisheng Zhang,Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation,J. Org. Chem.,2019,84, 780-791.\r
\r
Tong-Xin Liu,Shuaishuai Yue,Changgeng Wei,Nana Ma,Pengling Zhang,Qingfeng Liu,Guisheng Zhang,Solvent-promoted catalyst-free regioselective N-incorporation multicomponent domino reaction: rapid assembly of -functionalized [60]fullerene-fuseddihydrocarbolines, Chem. Commun.2018,54, 13331-13334.\r
\r
Lei Shi, Jingjing Xu, Jingjing Bi, Zhiguo Zhang, Tongxin Liu, Xiaolan Yang, Guisheng Zhang,Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine Compounds,Chinese J. Org. Chem.,2018,38, 3016-3025.\r
\r
Nana Ma,Changgeng Wei,Shujun Li,Guisheng Zhang,Theoretical insight on ethylene polymerization catalyzed by carborane-containing metal complexes: the role of carborane,Dalton T.,2018,47, 14421-14425.\r
\r
Lingjun Li,Shenlong Huang,Tongpeng Shang,Bo Zhang,Yuanyang Guo,Gongming Zhu,Demin Zhou,Guisheng Zhang,Anlian Zhu,Lihe Zhang,Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands,J. Org. Chem.,2018,83, 13166-13177.\r
\r
Hao Wu,Zhiguo Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu, Guisheng Zhang,Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions,J. Org. Chem.,2018,83, 12880-12886.
河南省特聘教授，享受国务院特殊津贴专家；有机化学重点学科学术带头人，绿色化学介质与反应教育部重点实验室副主任；河南省高校科技创新团队带头人，教育部“长江学者和创新团队发展计划”创新团队带头人；荣获全国优秀科技工作者，河南省劳动模范、河南省优秀专家、学术技术带头人等荣誉称号；国家基础科学人才培养基金评审专家，国际科技合作计划评价专家。