肖杰
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致力于食品功能活性物递送增效技术及健康效应评价研究:针对食源活性物功效发挥的限制性因素,特异性地制备递送增效体系以达到健康效应最大化的目的。研究聚焦新型递送体系的创建研究、结构解析及构效关系研究、增效机制及健康效应调控研究,以及以上基础理论在功能食品、活性包装领域的应用研究。 现为广东省珠江人才引进海外青年英才团队带头人、广东省青年珠江学者、广东省功能食品活性物重点实验室副主任。近五年发表相关SCI论文60余篇(其中第一/通讯作者SCI论文28篇,高引论文3篇),累计IF 超170, 他引超500次,出版英文专著章节1部, 第一发明人申请专利14件,已获授权4件。近五年主持课题项目包括广东省珠江人才引进海外青年英才团队项目、广东省食品科学青年珠江学者岗位计划项目、国家重点研发计划项目子课题、国家自然科学基金青年基金、广州市民生科技攻关项目、广东省教育厅特色创新项目、广东省高水平大学建设项目。承担教学 研究生课程:高级食品化学高级食品添加剂专题文献检索与论文写作食品科学研究进展现代食品检测分析技术(博士)本科生课程:食品添加剂食品化学科研项目➢酚类抗氧化物在皮克林乳液界面处的分配及调控机理研究➢皮克林双乳液基营养素共递送体系的构建及应用➢结肠靶向递送制剂的应用基础研究➢递送增效体系对功能食品因子健康效应的调控研究➢新型静电纺丝功能递送体系的开发研究➢功能递送体系活性/智能食品包装中的应用基础研究➢基于单向阻湿长效抗菌性包装的鲜切水果保鲜关键技术及应用示范获奖情况•广东省珠江人才引进海外青年英才团队核心带头人,2019-至今• 广东省食品科学青年珠江学者,2019-至今专利 授权专利:1. 肖杰,刘倩茹,王文博,罗敏娜,王玲.一种易挤爆且贮存稳定的爆珠卷嘴卷烟滤嘴,实用新型, ZL201820589768.0, 授权时间2018-12-21, 专利申请国别:中国2. 肖杰,陈霞,罗敏娜.一种单向阻湿的多层可食性膜及其制备方法,ZL201811066402.1, 授权时间:2018.06.15, 专利申请国别:中国申请专利:1. 肖杰,王玲,王文博,罗敏娜,陈霞. 一种基于双乳液结构的益生菌液态制剂及其制备方法,CN108853021A,申请时间2018-08-08,专利申请国别:中国2. 肖杰,罗敏娜,陈霞,王玲.一种缓释精油的可食性抗菌膜及其制备方法,CN108752610A申请时间:2018.04,专利申请国别:中国3. 肖杰,刘倩茹,罗敏娜,王文博,王玲.一种固载皮克林乳液抑菌膜及其制备方法和应用,CN109021262A,申请时间2018-05-04,专利申请国别:中国4. 肖杰,罗敏娜,王文博,欧杰财.一种控释型烟用香精膜及其制备方法和应用,CN108618198A,申请时间2018-04-04,专利申请国别:中国5. 肖杰,王玲,王文博,罗敏娜,赵梓军. 一种细菌纤维素稳定的皮克林双乳液及其制备方法,CN108851019A,申请时间2018-08-08,专利申请国别:中国6. 肖杰,陈霞,蔡济洋,刘宏生,王文博一种梯度缓释型的活性复合膜及其制备方法,CN2019104720150, 申请时间2019,专利申请国别:中国研究领域
1)食源活性物的稳态化及递送增效体系的创建新技术研究:“量体裁衣”解决活性物水溶性差、稳定性差、跨膜转运效率低、首过效应强、突释等问题,为膳食补充剂、日化、活性包装制品提供稳态化、高载量、缓控释和增效的创新技术。系列工作被遴选为2015年美国化学会农业与食品学部研究亮点;系列创建技术被2018年食品化学百科全书收录。2)递送增效体系的构效关系解析新方法研究:采用“他山之石”突破递送体系组装机制、多级结构、构效关系的解析方法难点。其中,计算机仿真模拟、X射线小角衍射分析等交叉学科分析方法提高了递送体系结构解析的效率与精度,特色和优势明显。研究获美国国立卫生研究院项目资助,成果被国内外同行采用;系列方法创新在Adv. Colloid Interface Sci.上发表高影响力文章。3)递送体系的增效机制与健康效应调控新理论研究:“承前启后”补足增效机制证据链条缺失,从递送体系的结构演变、活性物跨膜转运及代谢全过程的证据链角度完善递送体系的增效机制。并率先开展递送体系介导的健康效应调控研究,突破以“生物利用度最大化”为增效“黄金评价指标”的理论现状。相应观点在农化(学科TOP1期刊)发表的评论文章中首次指出,具有显著的理论创新价值。4)功能食品、活性包装领域的应用转化效果:乳液基递送体系在浊度功能饮料、营养素共递送制剂、益生菌制剂开发方面有应用前景,已公开核心发明专利技术2件;纳米粒子基上消化道吸收增强型递送制剂载药量可达5%,有效提高水不溶性功能活性物的消化吸收效率;可食性膜控释递送技术获授权专利2件,公开专利3件,形成中试生产线一条,开发了具有不同阻湿强度、缓释时效的系列活性物控释膜产品并形成应用示范。""近期论文
Zijun Zhao, Muwen Lu, Zhu Mao, Jie Xiao*, Qingrong Huang, Xuechun Lin, Yong Cao. Modulation of interfacial phenolic antioxidant distribution in Pickering emulsions via interactions between zein nanoparticles and gallic acid. Int. J. Biol. Macromal. 2020. (152):223–233 IF=4.784 JCR 生物2区 Ling Wang, Mingyue Song, Zijun Zhao, Xia Chen, Jiyang Cai, Yong Cao, Jie Xiao*, Lactobacillus acidophilus loaded Pickering double emulsion with enhanced viability and colon-adhesion efficiency. LWT-Food Science and Technology. 2019, 121: 108928, IF 4.17 工程技术JCR2区 Xia Chen, Feihe Cui, Hua Zi, Yichen Zhou, Hongsheng Liu*, Yunyi Yang, Peitao Zhu, Jie Xiao*.Development and characterization of a hydroxypropyl starch/zein bilayer edible film. International Journal of Biological Macromolecules. 2019,(141): 1175-1182 JCR生物2区, IF=4.784 Xia Chen, Wenbo Wang, Ling Wang, Hongsheng Liu, Jie Xiao*. Multilayer zein/gelatin films with tunable water barrier property and prolonged antioxidant activity. Food Packaging Shelf Life.2019,19:76-85IF 3.63 工程技术JCR2区,食品科学1区 0 Minna Luo, Yong Cao, Wenbo Wang, Xia Chen, Ling Wang, Jie Xiao*. Sustained-release antimicrobial gelatin film: Effect of chia mucilage on physicochemical and antimicrobial properties. Food Hydrocolloid. 2019, 87: 783-791 IF 5.836工程技术JCR2区,食品科学1区 26. Qian-Ru Liu, Wenbo Wang, Junru Qi, Qingrong Huang, Jie Xiao*. Oregano essential oil loaded soybean polysaccharide films: Effect of Pickering type immobilization on physical and antimicrobial properties, Food Hydrocolloid, 10.1016/j.foodhyd.2018.08.011 (IF: 5.07)7. Jianhua Liu, Jie Xiao #, Feng Li, Ying Shi, Dapeng Li, Qingrong Huang. Chitosan-sodium alginate nanoparticle as a delivery system for ε-polylysine: preparation, characterization and antimicrobial activity. Food Control. 2018, 91: 302-310 8. Feng Li, Huimiao Jin, Jie Xiao, Xusheng Yin, Xinying Liu, Dapeng Li, Qingrong Huang. The simultaneous loading of catechin and quercetin on chitosan-based nanoparticles as effective antioxidant and antibacterial agent. Food Research International. DOI: 10.1016/j.foodres.2018.05.0389. Jie Xiao and Qingrong Huang. Food nanotechnology in food materials research. Food materials science: Principles and applications. Editor: J. M. Aguilera, P.J. Lillford, Springer, New York, 2018 (Book Chapter) 10. Jie Xiao*, Wenbo Wang, Qingrong Huang, Yunqi Li. Edible delivery systems based on favorable interactions for encapsulation of phytochemicals. Encyclopedia of Food Chemistry. Available online in Reference Module in Food Science11. Wenbo Wang, Jie Xiao*, Xia Chen, Minna Luo, Hongsheng Liu, Ping Shao. Fabrication and characterization of multilayered kafirin/gelatin film with one-way water barrier property, Food Hydrocolloid, 2018, 81: 159-168 (IF:5.07)12. Jie Xiao, Yong Cao, Qingrong Huang, Edible nanoencapsulation vehicles for oral delivery of phytochemicals: A Perspective paper. J. Agric. Food Chem. 2017, 65: 6727–6735 (农学1区Top IF: 3.154, 4, 3)13. Jie Xiao, Ce Shi, Yunqi Li, Qingrong Huang. Pickering emulsion immobilized within hydrogel matrix with enhanced resistance toward harsh processing conditions and sequential digestion profile under simulated gastrointestinal tract. Food Hydrocolloid. 2017, 62:35-42. (1区IF: 4.747 ) 14.Jie Xiao, Xuanxuan Lu, Qingrong Huang. Double emulsion derived from kafirin nanoparticles stabilized Pickering emulsions: fabrication, microstructure, stability and in vitro digestion profile. Food Hydrocolloid. 2017, 62: 230-238. (1区IF: 3.858, IF: 4.637)15. Jie Xiao, Yunqi Li, Qingrong Huang. Application of Monte Carlo simulation in addressing key issues of complex coacervation formed between polyelectrolytes and oppositely charged colloids. Adv. Colloid Interface Sci. 2017, 239:31-45. (化学1区IF: 7.813, IF: 10.42)16. Jie Xiao, Yunqi Li, Qingrong Huang. Recent advances on food-grade particles stabilized Pickering emulsions: fabrication, characterization and research trends. Trends in Food Sci. Tech. 2016, 55:48-60. (1区IF: 5.15, IF: 5.54) 17. Jie Xiao, Ce Shi, Huijuan Zheng, Zhen Shi, Qingrong Huang. Kafirin protein based electrospun fibers with tunable mechanical property, wettability and release profile. J. Agric. Food Chem. 2016, 64 (16): 3226–33 (农学1区Top IF: 2.857, IF: 3.3)18. Jie Xiao, Chao Li, Qingrong Huang. Kafirin nanoparticle-stabilized Pickering emulsions as oral delivery vehicles: Physicochemical stability and in vitro digestion profile. J. Agric. Food Chem. 2016, 63(47): 10263-70. (农学1区Top IF: 2.857, IF: 3.3) 19. Jie Xiao, Xiang’an Wang, Alejandro Perez Gonzalez, Qingrong Huang. Kafirin nanoparticles-stabilized Pickering emulsions: Microstructure and rheological properties. Food Hydrocolloid. 2016, 54: 30-39. (1区IF: 3.858, IF: 4.637) 20. Jie Xiao, Ce Shi, Li Zhang, Qingrong Huang. Multilevel structural responses of β-conglycinin and glycinin under acidic or alkaline heat treatment. Food Res. Int. 2016, 89: 540–548 (食品科技2区 IF: 3.182, IF:3.871) 21. Jie Xiao, Si Nian, Qingrong Huang. Assembly of kafirin/carboxymethyl chitosan nanoparticles to enhance the cellular uptake of curcumin. Food Hydrocolloid. 2015, 51: 166-175. (1区IF: 3.858, IF: 4.637)22. Jie Xiao, Yunqi Li, Ji Li, Alejandro Perez Gonzalez, Qiuyang Xia, Qingrong Huang. Structure, morphology and assembly behavior of kafirin. J. Agric. Food Chem. 2015, 63(1): 216–224. (1区Top IF: 2.857, IF: 3.3) 23. Jie Xiao, Jian Sun, Lingyun Yao, Xiaodong Wang, Xiaofan Yuan, Bing Zhao. Physicochemical characteristics of ultrasonic extracted polysaccharides from cordyceps cephalosporium mycelia. Int. J. Biol. Macromol. 2012, 51(1-2):64-69. (生物3区IF: 3.138, IF: 3.220) 相关热点
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