个人简历

2016-至今，华南理工大学博士生导师 2009-2016，中国科技大学生命科学学院免疫所教授 2007-2009，美国加利福尼亚大学戴维斯分校副教授 2003-2007，美国加利福尼亚大学戴维斯分校资深研究员 2000-2003，美国加利福尼亚大学戴维斯分校博士后 1998-2000，美国纽约大学北岸医院研究员 1994-1998，日本关西医科大学，第一病理博士 1992-1994，日本关西医科大学，第一病理研究员 1989-1992，长春生物制品研究所实习研究员

研究领域

自身免疫性疾病和肝脏慢性炎症性疾病的基础免疫学研究，治疗靶点和免疫药物研发；肿瘤免疫学发病机制及治疗靶点。

近期论文

1. Gao C-Y, Yao Y, Li L, Yang S-H, Chu H, Tsuneyama K, Li X-M, Gershwin ME and Lian Z-X*.(2018) Tissue resident memory CD8+ T cells mediate salivary gland damage in a murine model of Sjogren's syndrome. Arthritis Rheumatol (2017 IF:7.87). Online. 2. Liu Q-Z, Ma W-T, Yang J-B, Zhao Z-B, Yan K, Yao Y, Li L, Miao Q, Gershwin ME and Lian Z-X*.(2018) The CXC Chemokine Receptor 3 Inhibits Autoimmune Cholangitis via CD8(+) T Cells but Promotes Colitis via CD4(+) T Cells. Front Immunol (2017 IF:5.51). 9: p. 1090. 3. Yao Y, Li L, Yang S-H, Gao C-Y, Liao L-H, Xie Y-Q, Yin X-Y, Yang Y-Q, Fei Y-Y and Lian Z-X*.(2018) CD8+ T cells and IFN-γ induce autoimmune myelofibrosis in mice. J Autoimmun (2017 IF:7.61). 89: p. 101-111. 4. Zhao Z-B, Long J, Zhao Y-Y, Yang J-B, Jiang W, Liu Q-Z, Yan K, Li L, Wang Y-C and Lian Z-X*. (2018) Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles. Biomater Sci (2017 IF:5.83). 6(4): p. 893-900. 5. Yang J-B, Zhao Z-B, Liu Q-Z, Hu T-D, Long J, Yan K and Lian Z-X*. (2017) FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor associated macrophages. Oncogene(2017 IF:6.85). 37(9): p. 1192-1204. 6. Yang S-H, Li L, Xie Y-Q, Yao Y, Gao C-Y, Liao L-H, Ma H-D, Gershwin ME and Lian Z-X*. (2017) IFN-γ-STAT1-INOS induces myeloid progenitors to acquire T cell suppressive activity in Con A induced Autoimmune Hepatitis. Frontiers in Immunology (2017 IF:5.51). 8:1192. 7.Ma W-T, Jia Y-J, Liu Q-Z, Yang Y-Q, Yang J-B, Zhao Z-B, Yang Z-Y, Shi Q-H, Ma H-D*, Gershwin ME and Lian Z-X*. (2017) Modulation of liver regeneration via myeloid PTEN deficiency. Cell Death & Disease (2017 IF:5.64). 8:e2827. 8. Ma H-D, Ma W-T, Liu Q-Z, Zhao Z-B, Liu M-Z-Y, Tsuneyama K, Gao J-M, Ridgway WM, Ansari AA, Gershwin ME, Fei Y-Y* and Lian Z-X*. (2017) Chemokine Receptor CXCR3 Deficiency Exacerbates Murine Autoimmune Cholangitis by Promoting Pathogenic CD8+ T Cell Activation. J Autoimmunity (2017 IF:7.61). 78:19-28. 9. Li L, Yang S-H, Yao Y, Xie Y-Q, Yang Y-Q, Wang Y-H, Yin X-Y, Ma H-D*, Gershwin ME and Lian Z-X*. (2016) Block of both TGF-β and IL-2 signaling impeded Nrp-1+ regulatory T cell and follicular regulatory T cell development. Cell Death & Disease (2017 IF:5.64). 7:e2439. 10. Wang Y-C, Ma H-D*, Yin X-Y, Wang Y-H, Liu Q-Z, Yang J-B, Shi Q-H, Sun B, Gershwin ME and Lian Z-X*. (2016) Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature. Clin Rev Allergy Immunol (2017 IF:6.44). 51:353-369. 11. Yang J-B, Wang Y-H, Yang W, Lu F-T, Ma H-D, Zhao Z-B, Jia Y-J, Tang W, Tsuneyama K, Ridgway WM, Gershwin ME and Lian Z-X*. (2016) Successful Treatment of Murine Autoimmune Cholangitis by Parabiosis. J Autoimmunity (2017 IF:7.61). 66:108-117. 12.Lu F-T, Yang W, Wang Y-H, Ma H-D, Tang W, Yang J-B, Li L, Aftab A. Ansari and Lian Z-X*. (2015) Thymic B cells promote regulatory T cell development and proliferation. J Autoimmunity (2017 IF:7.61). 61:62-72. 13. Wang Y-H, Yang W, Yang J-B, Jia Y-J, Tang W, Gershwin ME, William M. Ridgway and Lian Z-X*. (2015) Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis. J Autoimmunity (2017 IF:7.61). 59:26-37. 14. Ma H-D, Wang Y-H, Chang C, Gershwin ME and Lian Z-X*. (2015) The Intestinal Microbiota and Microenvironment in Liver. Autoimmunity Reviews (2017 IF:8.75). 14:183-191. 15. Yao Y, Yang W, Yang Y-Q, Ma H-D, Lu F-T, Li L, Tao Y-Y, Tsuneyama K, Zhang W, Friedman S, Gershwin ME and Lian Z-X*. (2014) Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα-/- mice. J Autoimmunity (2017 IF:7.61). 51:99-108. 16. Deng Y-R, Yoshida K, Jin Q, Murata M, Yamaguchi T, Tsuneyama K, Moritoki Y, Niu J, Matsuzaki K and Lian Z-X*. (2014) Reversible phosphor-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in chronic hepatitis B infection. Clinical Experimental Immunology (2017 IF:3.54). 176:102-111. 17. Deng Y-R, Ma H-D, Tsuneyama K, Yang W, Wang Y-H, Lu F-T, Liu C-H, Liu P, He X-S, Diehl AM, Gershwin ME and Lian Z-X*. (2013) STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. J Autoimmunity (2017 IF:7.61). 49:25-34. 18. Ma H-D, Deng Y-R, Tian Z and Lian Z-X*.(2013) Traditional Chinese Medicine and Immune Regulation. Clin Rev Allergy Immunol (2017 IF:6.44). 44:229-241. 19. Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung P, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian Z-X*, Flavell R, He XS and Gershwin ME*. (2013) Deletion of IL-12p35 induces liver fibrosis in dominant negative transforming growth factor β receptor type II mice. Hepatology (2017 IF:14.08). 57:806-16. 20. Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang G-X, Bowlus C, Ridgway W, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME* and Lian Z-X*. (2009) B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology (2017 IF:20.77). 136:1037-1047.