个人简历

1980年出生于中国台湾，2011年毕业于台湾成功大学基础医学研究所，获得理学博士学位。2012年--2018年于台湾成功大学医学检验及生物科技学系从事博士后研究，2018年担任台湾成功大学兼任助理教授，同年被聘为湖南大学教授、博士生导师。2013年获颁台湾科技部博士后研究人员学术著作奖，207年获颁台湾肝病防治学术基金会肝病防治优秀论文奖。参与台湾科技部及产学研合作多项专题研究计划，2017年作为CO-PI主持台湾成功大学/秀传医疗体系合作计划。教育背景 博士国立成功大学 基础医学研究所2004/9~2011/6 硕士国立成功大学 分子医学研究所2002/9~2004/6 学士国立中兴大学动物系 1998/9~2002/6 工作履历 2018/09-今 湖南大学生物医学工程学系 教授 2018/09-今 台湾成功大学分子医学研究所 兼任助理教授 2011/08-2018/09 台湾成功大学医学检验生物技术学系 博士后研究员 2016/11-2016/12 加拿大渥太华生物及微生物免疫学系 访问博士后研究员

研究领域

主要从事脂蛋白/载脂蛋白代谢，肝炎病毒学，细胞生物学，分子病毒学及微生物致病机转领域的科研工作。长期研究目标为探讨载脂蛋白及脂蛋白调控胞内/外脂肪累积之分子机制，于肝炎病毒，代谢性疾病及细胞癌化之应用，具体工作目标包括载脂蛋白于脂肪酸及病毒诱发脂肪累积之机制，载脂蛋白于代谢相关疾病临床显着性，构筑代谢相关疾病之载脂蛋白与脂肪体数据库及寻找能够预防或治疗脂肪累积之小分子药物。

近期论文

1. Yu-Min Lin, Hung-Yu Sun, Wen-Tai Chiu, Hui-Chen Su, Yu-Chieh Chien,Lee-Won Chong, Hung-Chuen Chang, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao. Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation. Viruses, 2018 (Impact Factor 3.761) 2. Hung-Yu Sun*, Pin-Nan Cheng, Chiung-Ying Tseng, Wei-Jen Tsai, Yen-Cheng Chiu, Kung-Chia Young. Favoring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic hepatitis C virus infection. GUT, 2018. 67:1342-1350 (Impact Factor 17.016) 3. Peiju Tsai, Chun-Chieh Lin, Hung-Yu Sun, Jin-Ching Lee, Ting-Tsung Chang, Kung-Chia Young. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient’s viremia. Journal of Microbiology, Immunology and Infection. 2018. 51:446-455. (Impact Factor 2.094) 4. Hung-Yu Sun*, Chun-Chieh Lin, Pei-Ju Tsai, Wei-Jen Tsai, Jin-Ching Lee, Chiung-Wen Tsao, Pin-Nan Cheng, I-Chin Wu, Yen-Cheng Chiu, Ting-Tsung Chang, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cellular Microbiology, 2017. 19: e12673. (Impact Factor 4.41) 5. Yu-Min Lin, Bu-Chin Yu, Wen-Tai Chiu, Hung-Yu Sun, Yu-Chieh Chien, Hui-Chen Su, Shu-Yang Yen, Hsin-Wen Lai, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao. Fluoxetine regulates cell growth inhibition of interferon-&alpha. International Journal of Oncology, 2016. 49:1746-54. (Impact Factor 3.333) 6. Cheng-Hsun Ho, Huai-Chia Chuang, I-Chin Wu, Hung-Wen Tsai, Yih-Jyh Lin, Hung-Yu Sun, Kung-Chia Young, Yen-Cheng Chiu, Pin-Nan Cheng, Wen-Chun Liu, Tse-Hua Tan, Ting-Tsung Chang. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget, 2016. 7: 49765-49776 7. Chun-Chieh Lin, Peiju Tsai, Hung-Yu Sun, Mei-Chi Hsu, Jin-Ching Lee, I-Chin Wu, Chiung-Wen Tsao, Ting-Tsung Chang, Kung-Chia Young. Apolipoprotein J, a glucose up-regulated molecular chaperone stabilizes core and NS5A to promote infectious hepatitis C virus virion production, Journal of Hepatology, 2014; 61: 984-93. (Impact Factor 12.486) 8. Jin-Ching Lee, Chin-Kai Tseng, Kung-Chia Young, Hung-Yu Sun, Shainn-Wei Wang, Wei-Chun Chen, Chun-Kuang Lin, Yu-Hsuan Wu. Andrographolide exerts anti-hepatitis C virus activity by upregulating heme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. BRITISH JOURNAL OF PHARMACOLOGY, 2014; 171: 237-252. (Impact Factor 6.81) 9. Hung-Yu Sun*, Chun-Chieh Lin, Jin-Ching Lee, Shainn-Wei Wang, Pin-Nan Cheng, I-Chin Wu, Ting-Tsung Chang, Ming-Derg Lai, Dar-Bin Shieh, Kung-Chia Young. Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. GUT, 2013; 62:1193-1203. (Impact Factor 17.016) 10. Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin and Kung-Chia Young. The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in taiwanese breast cancer patients: a 10-year follow-up study. BMC CANCER, 2013; 13:330. (Impact Factor 3.288) 11. M-C Hsu, C-S Chang, K-T Lee, H-Y Sun, Y-S Tsai, P-H Kuo, K-C Young and CH Wu. Central obesity in males affected by a dyslipidemia associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster. Nutrition & Diabetes, 2013; 3: e06. (Impact Factor 3.534) 12. Sun HY*, Ou NY, Wang SW, Liu WC, Cheng TF, Shr SJ, Sun KT, Chang TT, Young KC (2011) Novel Nucleotide and Amino Acid Covariation between the 5'UTR and the NS2/NS3 proteins of Hepatitis C Virus: Bioinformatic and Functional Analyses. PLoS One. 6: e25530 (Impact Factor 2.806) 13. Sun HY*, Chen SF, Lai MD, Chang TT, Chen TL, Li PY, Shieh DB, Young KC (2010) Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clin Chim Acta 411: 336-344. (Impact Factor 2.873)