个人简历

教育经历
1995.08-2000.07 军事医学科学院基础医学研究所免疫学专业 获博士学位
1990.09-1995.07 第四军医大学临床医学专业 获学士学位
工作经历
2010.09-至今 军事医学科学院基础医学研究所 研究员
2006.09-2010.08 军事医学科学院基础医学研究所 副研究员
2003.05-2005.12 芝加哥大学Ben-May癌症研究所 博士后
2000.07-2006.08 军事医学科学院基础医学研究所 助理研究员
主要学术荣誉
(1) 2007.12 中国科协“第四届中国青年女科学家奖”
(2) 2008.08 中国免疫学会“青年学者奖”
(3) 2008.12 中国人民解放军总后勤部“科技新星”
(4) 2012.01 中国人民解放军“高层次科技创新拔尖人才”
所获奖励
(1) 北京市科技进步二等奖 (2008)，排名第2 称：基于受体-配体、抗原-抗体相互作用的立体结构信息设计新功能分子
(2) 2010年中国石油和化学工业优秀科技图书奖二等奖，主编 名称：《分子免疫学实验指南》

近期论文

1) Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, Wang W, Cao J, Han K, Cheng Q, Shen B, Chen Y, Zhang W, Ma Y, Zhang J*. RACK1 promotes autophagy by enhancing the Atg14L-Beclin 1-Vps34-Vps15 complex formation upon phosphorylation by AMPK. Cell Rep 2015; 13(7):1407-17. 8.358
2) Wang W, Jiang M, Liu S, Zhang S, Liu W, Ma Y, Zhang L, Zhang J*, Cao X*. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9581-6.
3) Zhu T, Wang J, Pei Y, Wang Q, Wu Y, Qiu G, Zhang D, Lv M, Li W, Zhang J*. Neddylation controls basal MKK7 kinase activity in breast cancer cells. Oncogene 2016; 35(20):2624-33.8.459
4) Wang X, Wang Q, Zhang X, Li Y, Wang J, Hou C, Chen J, Shen B, Shi Y, Zhang J*. Endotoxic shock-expanded murine CD11clowCD45RB+ regulatory dendritic cells modulate inflammatory T cell responses through multiple mechanisms. Sci Reports 2015 May 29;5:10653. doi: 10.1038/srep10653.5.578
5) Wang Q, Zhou S, Wang JY, Cao J, Zhang X, Wang J, Han K, Cheng Q, Qiu G, Zhao Y, Li X, Qiao C, Li Y, Hou C, Zhang J*. RACK1 antagonizes TNF-a-induced cell death by promoting p38 activation. Sci Reports 2015 Sep 18;5:14298. doi: 10.1038/srep14298.5.578
6) Cao J, Zhang X, Wang Q, Qiu G, Hou C, Wang J, Cheng Q, Lan Y, Han H, Shen H, Zhang Y, Yang X, Shen B, Zhang J*. Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells. Cell Death Dis 2015 Nov 19; 6:e1984. doi: 10.1038/cddis.2015.337.5.014
7) Han K, Wang Q, Cao H, Qiu G, Cao J, Li X, Wang J, Shen B, Zhang J. The NEDD-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia. Oncotarget 2016; 7(17);23812-24. 6.359
8) Zhang X, Ye Z, Pei Y, Qiu G, Wang Q, Xu Y, Shen B, Zhang J*. Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production. Cell Mol immunol 2016 Sep; 13(5): 578-83.4.112
9) Zhang D, Wang Q, Zhu T, Cao J, Zhang X, Wang J, Wang X, Li Y, Shen B, Zhang J*. RACK1 promotes the proliferation of THP1 acute myeloid leukemia cells. Mol Cell Biochem 2013;384(1-2):197-202.2.388
10) Cao J, Zhang X, Wang Q, Wang X, Jin J, Zhu T, Zhang D, Wang W, Li X, Li Y, Shen B, Zhang J*. Cyclic AMP suppresses TGF-β-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK. Cell Immunol 2013; 285(1-2):42-8.1.874
11) Zhang J*, Shen B. SHP limits TLR signaling, an inducible transcriptional cprepressor. Cell Mol Immunol 2011; 8(6): 445-6.2.992
12) Zhang J*, Wang Q, Zhu N, Yu M, Shen B, Xiang J, Lin A. Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis. Cell Death Differ 2008; 15: 1654-62.2008年: 影响因子:8.254
13) Zhang J*, Shen B, Lin A. Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol Sci. 2007; 28: 286-95.10.4
14) Wang J, Minemoto Y, Lin A, Li Y, Shen B, Zhang J*. IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-kB activity. Mol Immunol 2007; 44: 2139-43.4.768
中国免疫学会理事
中国人民解放军免疫学专业委员会常委
国家自然科学基金委员会医学科学部评审组专家
中国免疫学会英文会刊《Cell Mol Immunol》杂志editor
中国免疫学会中文会刊《中国免疫学杂志》副主编
北京市生物化学学会理事
北京市免疫学会常务理事
军事医学科学院学位审定委员会委员