孙华
近期热点
资料介绍
个人简历
受教育经历(EducationalExperience):2013/09-2016/06,暨南大学,药学院中药化学,博士2010/09-2010/06,暨南大学,药学院药物化学,硕士2006/09-2010/06,烟台大学,药学院药学,学士工作经历(ProfessionalExperience):2016/07–至今,河南大学,药学院,讲师;研究兴趣(ResearchInterests):药物代谢动力学、肿瘤药理学。承担项目情况(FinancialSupports)[1]外排转运体影响中药酚性物质磺酸化代谢及作用机制研究,81703801,20万,2018/01-2020/12,国家自然科学基金青年基金,主持人。[2]硫酸酯酶调控中药酚性物质外排-代谢相互作用机制研究,2018M632764,5万元,2018.04-2020.03,中国博士后面上资助,主持人。[3]中药酚性物质调控雌激素II相代谢对乳腺癌增殖和转移的影响及机制研究,2019HYTP025,5万,2019.01.01-2020.12,河南省青年人才托举工程项目,主持人。[4]芳基磺酸苷水解酶调控中药酚性物质磺酸化代谢的机制研究,10万,2018.01-2019.12,河南省博士后“科研项目启动经费”,主持人。[5]外排转运体调控中药酚性物质磺酸化代谢及作用机制研究,18A350004,3万元,2018.01-2019.12,河南省教育厅科学技术研究重点项目,主持人。[6]中药酚性物质影响雌激素SULT代谢的作用及机制研究,2019015,5万,2020.01-2021.12,河南大学医学院青年人才科研培育计划项目,主持人。[7]基于EGFR介导的β-catenin浆核穿梭研究AKT1对乳腺癌转移的负性调控,81772832,53万元,2018.01-2021.12,国家自然科学基金面上项目,参与。[8]Wnt5b介导P2X3受体上膜的机制及其在骨癌痛中的作用研究,81701110,20万元,2018.01-2020.12,国家自然科学基金青年基金,参与。奖励(Awards):[1]吴宝剑,董栋,张天鹏,王帅,卢丹逸,赵梦静,孙华,酚性药物代谢特征及调控机制的研究,广东省省人民政府,广东省省科技技术奖,2019近期论文
[1]ZhangXiaojing#,LiuTong#,ZhangYidan,LiuFanye,LiHaiying,FangDong,WangChaojie,SunHua*,XieSongqiang*,ElucidationoftheDifferencesinCinobufotalin’sPharmacokineticsBetweenNormalandDiethylnitrosamine-InjuredRats:TheRoleofP-Glycoprotein.Front.Pharmacol.,2019;10:521.[2]LiuTong#,ZhangXiaojing#,ZhangYidan,HouJiuzhou,FangDong,SunHua*,LiQin*,XieSongqiang*,SulfationdispositionofliquiritigenininSULT1A3overexpressingHEK293cells:Theroleofbreastcancerresistanceprotein(BCRP)andmultidrugresistance-associatedprotein4(MRP4)insulfateeffluxofliquiritigenin[J].EurJPharmSci.,volume124,pages228-239,2018.[3]SunHua#,LiuHui#,ZhaoHuinan,WangYing,LiYaolan,YeWencai*,WuBaojian*,PharmacokineticcharacterizationofanhuienosideCanditsdeglycosylatedmetabolitesinrats[J].Xenobiotica,volume47,issue10,pages885-893,2017.[4]SunHua#,ZhouXiaotong#,ZhangXingwang,WuBaojian*,DecreasedExpressionofMultidrugResistance-AssociatedProtein4(MRP4/ABCC4)LeadstoReducedGlucuronidationofFlavonoidsinUGT1A1-OverexpressingHeLaCells:TheRoleofFutileRecycling[J],JAgricFoodChem,volume63,issue26,pages6001-6008,2015.[5]SunHua#,WangXiao#,ZhouXiaotong,LuDanyi,MaZhiguo,WuBaojian*,MultidrugResistance-AssociatedProtein4(MRP4/ABCC4)ControlsEffluxTransportofHesperetinSulfatesinSulfotransferase1A3-OverexpressingHumanEmbryonicKidney293Cells[J].DrugMetabDispos,volume43,issue10,pages1430-1440,2015.[6]LiWan#,SunHua#,ZhangXingwang,WangHuan,Wubaojian*.EffluxtransportofchrysinandapigeninsulfatesinHEK293cellsoverexpressingSULT1A3:Theroleofmultidrugresistance-associatedprotein4(MRP4/ABCC4)[J].BiochemPharmacol,volume98,issue1,pages203-214,2015.[7]SunHua#,MaZhiguo#,LuDanyi,WuBaojian*,Regio-andIsoform-SpecificGlucuronidationofPsoralidin:Evaluationof3-O-GlucuronidationasaFunctionalMarkerforUGT1A9[J].JPharmSci,volume104,issue7,pages2369-2377,2015.[8]SunHua#,ZhouXiaotong#,WuBaojian*.AccurateidentificationofUDP-glucuronosyltransferase1A1(UGT1A1)inhibitorsusingUGT1A1-overexpressingHeLacells[J].Xenobiotica,volume45,issue11,pages945-953,2015.[9]SunHua#,WangHuan#,LiuHongming,ZhangXingwang,WuBaojian*,GlucuronidationofcapsaicinbylivermicrosomesandexpressedUGTenzymes:reactionkinetics,contributionofindividualenzymesandmarkedspeciesdifferences[J].ExpertOpinDrugMetabToxicol,volume10,issue10,pages1325-1336,2014.[10]SunHua,ZhangTianpeng,WuZhufeng,WuBaojian*.WarfarinisanEffectiveModifierofMultipleUDP-GlucuronosyltransferaseEnzymes:EvaluationofitsPotentialtoAlterthePharmacokineticsofZidovudine[J].JPharmSci,;volume104,issue1,pages244-256,2014. 相关热点
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