个人简历

2012.9-2016.6 海南大学 南药学 研究生/博士
2005.9-2008.6 海南大学 水产养殖 研究生/硕士
2000.9-2004.6 河南师范大学 生物科学 本科/学士

近期论文

1. Tang T, Zhang Z,Zhu X*. Toxic Effects of TiO? NPs on Zebrafish.Int. J. Environ. Res. Public Health. 2019, 16(4), 523. (SCI, IF2017=2.145)
2. Xu M#,Zhu X#, Yu J, Yu J, Luo S, Wang X. The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes.Protein & Cell, 2017, 8 (9): 675-685. (SCI, IF2017=6.228）
3.Zhu X, Bi J, Yu J, Li X, Zhang Y, Zhangsun D, Luo S. Recombinant Expression and Characterization of α-Conotoxin LvIA inEscherichia coli.Marine Drugs, 2016, 14 (1):11. (SCI, IF2016=3.503)
4. Ren J,Zhu X, Xu P, Li R, Fu Y, Dong S, Zhangsun D, Wu Y, Luo S. d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability.Marine Drugs, 2019, 17(3), 142. (SCI, IF2017=4.379)
5. Yu J,Zhu X, Harvey PJ, Kaas Q, Zhangsun D, Craik DJ, Luo S. Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist.Journal of Medicinal Chemistry, 2018, 61(20): 9256-9265. (SCI, IF2017=6.253）
6. Yu J,Zhu X, Zhang L, Kudryavtsev D, Kasheverov I, Lei Y, Zhangsun D, Tsetlin V, Luo S. Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists.Neuropharmacology, 2018, 139: 226-237. (SCI, IF2017=4.249）
7. Ren J, Li R, Ning J,Zhu X, Zhangsun D, Wu Y, Luo S. Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor.Marine Drugs, 2018, 16(6), 215. (SCI, IF2017=4.379)
8. Yu J,Zhu X, Yang Y, Luo S, Zhangsun D. Expression inEscherichia coliof fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product.Chem Biol Drug Des., 2018, 91(2): 349-358. (SCI, IF2017=2.328)
9. Zhangsun D,Zhu X, Kaas Q, Wu Y, Craik DJ, McIntosh JM, Luo S. αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.Neuropharmacology, 2017, 127: 243-252. (SCI, IF2017=4.249)
10.Wu Y, Zhangsun D,Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S. α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.Journal of Medicinal Chemistry, 2017, 60 (13): 5826-5833. (SCI, IF2017=6.253)
11.Lin B, Xu M,Zhu X, Wu Y, Liu X, Zhangsun D, Hu Y, Xiang SH, Kasheverov IE, Tsetlin VI, Wang X, Luo S. From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.Scientific Reports, 2016, 6: 22349. (SCI, IF20155=5.228)
12.Zhangsun D,Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S. Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.Journal of Biological Chemistry, 2015, 290(15): 9855-9862. (SCI, IF2015=4.258)
13.Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y,Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, Craik DJ, McIntosh JM. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor.Proc Natl Acad Sci U S A, 2015, 112(30): E4026-4035. (SCI, IF2015=9.423)
14.Luo S, Zhangsun D, Schroeder CI,Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P. A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.FASEB Journal, 2014, 28(4): 1842-1853. (SCI, IF2014=5.043)
15.Wu Y, Wu X, Yu J,Zhu X, Zhangsun D, Luo S. Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA.Molecules, 2014, 19(1): 966-979. (SCI, IF2014=2.416)
16.Luo S, Zhangsun D,Zhu X, Wu Y, Hu Y, Christensen S, Harvey PJ, Akcan M, Craik DJ, McIntosh JM. Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors.Journal of Medicinal Chemistry, 2013, 56(23):9655-9663. (SCI, IF2013=5.480)
17.Luo S, Christensen S, Zhangsun D, Wu Y, Hu Y,Zhu X, Chhabra S, Norton RS, McIntosh JM, A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.PLoS One, 2013, 8(1): e54648. (SCI, IF2013=3.534)
18.Luo S, Zhangsun D, Wu Y,Zhu X, Hu Y, McIntyre M, Christensen S, Akcan M, Craik DJ, McIntosh JM. Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors.Journal of Biological Chemistry, 2013, 288(2):894-902. (SCI, IF2013=4.60)
19.朱晓鹏, 于津鹏, 黄艺, 雷宇苗, 长孙东亭, 罗素兰. α3β2与α3β4烟碱型乙酰胆碱受体α和β亚基不同配比的药理活性研究.中国病理生理杂志, 2017, 33 ( 6): 961-967.
20.朱晓鹏, 于津鹏, 雷宇苗, 黄艺, 长孙东亭, 罗素兰. α7烟碱型乙酰胆碱受体点突变体的制备及其功能研究.中国海洋药物, 2017, 36 (3): 73-80.