个人简历

2013.9-2018.12 海南大学 生物化学与分子生物学 博士研究生/博士
2011.9-2013.7 海南大学 生物化学与分子生物学 硕士研究生/硕士
2006.9-2010.7 中国药科大学 生物技术 本科/学士

研究领域

多年来主要应用多肽的人工氧化折叠和分析纯化、非洲爪蟾卵母细胞上nAChRs电生理筛选模型的建立和配体药物的靶点鉴定、受体亚基突变体的构建等技术，对海南产芋螺毒素的构效关系进行研究

近期论文

1、Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J., Luo, S.. Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nAChR antagonist [J].J Med Chem, 2018, 61: 9256?9265.
2、Yu, J., Zhu, X., Zhang, L., Kudryavtsev, D.S., Kasheverov, I.E., Lei, Y., Zhangsun, D., Tsetlin, V.I., Luo, S.. Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists [J].Neuropharmacology, 2018, 139: 226-237.
3、Yu, J., Zhu, X., Yang, Y., Luo, S., Zhangsun, D.. Expression inEscherichia coliof fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product [J].Chem Biol Drug Des, 2018, 91(2): 349-358.
4、Xu, M., Zhu, X., Yu, J.,Yu, J., Luo, S., Wang, X.. The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes [J].Protein Cell, 2017, 8(9): 675-685.
5、Zhu, X., Bi, J.,Yu, J., Li, X., Zhang, Y., Zhangsun, D., Luo, S.. Recombinant expression and characterization of α-conotoxin LvIA inEscherichia coli[J].Marine Drugs, 2016,14(1):11.
6、Wu, Y., Wu, X.,Yu, J., Zhu, X., Zhangsun, D., Luo, S.. Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA [J].Molecules, 2014, 19(1): 966-979.
7、Gao, B., Zhangsun, D., Hu, Y., Wu, Y., Shen, L., Fang, L., Wu, X.,Yu, J., Luo, S.. Expression and secretion of functional recombinant μO-conotoxin MrVIB-His-tag in Escherichia coli [J]. Toxicon, 2013, 72: 81-89.