孙先宇
近期热点
资料介绍
个人简历
教育经历起止年月学校名称院(系)名称专业名称获得学位类别2007.9-2010.7延边大学药学药物化学博士2004.9-2007.7延边大学药学药物化学硕士2000.9-2004.7延边大学药学药学学士专利1、4,5-二氢咪唑[1,2-a]喹啉衍生物及其应用,国家发明专利,ZL201210422267.0科研项目1、国家自然科学基金项目,弥漫性大B细胞淋巴瘤治疗药物BCL6抑制剂的筛选,2016.1-2018.12,17.8万元,主持。2、黑龙江省青年科学基金项目,QC2014C106,特异性COX-2抑制剂的设计、合成及筛选,2014/7-2017/7,5万元,主持。3、黑龙江省高校青年学术骨干项目,1252G041,N-(2-取代-4-氧代噻唑-3-基)异烟胺:合成、抗炎活性筛选及3D-QSAR研究,2012/4–2015/12,4万元,主持。4、黑龙江八一农垦大学博士科研启动项目,B2011-10,新型喹啉类抗菌药物的设计、合成及活性筛选,2011/5–2015/12,5万元,主持。研究领域
新药的设计及活性筛选近期论文
1)Xian-yuSun,Chun-yanZhong,Qing-qingQiu,Zhen-wangLi,Mei-yuLiu,XinWang&Cheng-haoJin.Synthesis,activityevaluation,andpro-apoptoticpropertiesofnovel1,2,4-triazol-3-aminederivativesaspotentanti-lungcanceragents.JournalofEnzymeInhibitionandMedicinalChemistry,2019,34(1),1210-1217.2)XianyuSun,MeiyuLiu.SynthesisandAntibacterialEvaluationof2-Ethyl-1-(4-substituted)phenyl-1H-imidazoleDerivativesasOpen-ChainAnaloguesof7-Alkoxyl-4,5-dihydroimidazo[1,2-a]quinolines.JjournaloftheBrazilianChemicalSociety,2018,29(4),701-707.3)XianyuSun,ChunyanZhong.Design,SynthesisandActivityEvaluationof2-Ethyl-1-(4-substituted)Phenyl-1H-ImidazoleDerivativesasPotentAntibacterialAgents.LatinAmericanJournalofPharmacy,2018,37(4):768-7744)ChaoXie;ZhouPeng;Shui-LianZhao;Cheng-YanPan;Li-PingGuan;Xian-YuSun,2014,Synthesisof2´-hydroxy-4´-isoprenyloxychalconeDerivativeswithPotentialAntidepressant-likeActivity,MedicinalChemistry,2014,10(8),789-7995)XianyuSun;RachitaRai;AlexanderD.MacKerellJr.;AlanI.Faden;FengtianXue.Facileone-stepsynthesisof2,5-diketopiperazines.TetrahedronLetters,2014,55,1905-8.6)XianyuSun;RachitaRai;JeffreyR.Deschs;AlexanderD.MacKerellJr.;AlanI.Faden;FengtianXue.Boc-protected1-1(3-oxocycloalkyl)ureasviaaone-stepCurtiusrearrangement:mechanismandscope.TetrahedronLetters,2014,55,842-4.7)Xian-YuSun;RuiWu;XiangWen;LiGuo;Chang-PingZhou;JianLi;Zhe-ShanQuan;JunBao.Synthesisandevaluationofantibacterialactivityof7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinolinederivatives.EuropeanJournalofMedicinalChemistry,2013,60,451-5.8)Xian-YuSun;Xian-JingHe;Chun-YuanPan;Yan-PengLiu;Yun-PengZou.Synthesisandstudyoftheantidepressantactivityofnovel4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinolinederivatives.MedicinalChemistryResearch,2012,10,3692-8.9)Hai-LingYu;Xian-QingDeng;Ying-JunLi;Ying-ChunLi;Zhe-ShanQuan;Xian-YuSun.N-palmitoylethanolamide,anendocannabinoid,exhibitsantidepressanteffectsintheforcedswimtestandthetailsuspensiontestinmice.PharmacolRep.2011,834-9.10)Xian-YuSun;ChuanHu;Xian-QingDeng;Cheng-XiWei;Zhi-GangSun;Zhe-ShanQuan.SynthesisandAnti-inflammatoryActivityEvaluationofSomeNovel6-Alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-aminederivatives.EurJMedChem.2010,11,4807-12. 相关热点
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