个人简历

工作经历
2017/12-迄今 哈尔滨工业大学生命科学中心 研究员
2014/01-2017/12 范安德研究所,密西根州 研究助理教授
2008/09-2014/01 范安德研究所，密西根州 研究科学家
2005/09-2008/09 美国国立卫生研究院，马里兰州 研究学者
2000/10-2005/09 美国国立卫生研究院，马里兰州 博士后
教育经历
1995/09-2000/07 中科院上海生化所 分子生物学 博士
1991/09-1995/07 南京大学 生理学 本科
教学
生物大分子及结构生物学专题膜蛋白受体部分
加入我们！
我们欢迎有志于挑战具有前瞻性和重要药用价值的膜蛋白受体结构的学子（博士后，博士，硕士和本科生）加入受体结构和信号实验室（Laboratory of Receptor Structure and Signaling, LRSS)这个充满活力团队。有兴趣者请与何元政研究员联系。

研究领域

激素类受体，包括糖皮质类激素受体（Glucocorticoid Receptor）和G蛋白偶联受体（G-protein coupled receptors， GPCR）的结构，信号传导和相应的疾病药物开发。总体研究目标是利用各种结构生物学手段，包括是当前新兴的冷冻电镜技术，来解决信号传导上的关键机制，并转化成与疾病直接相关的治疗和药物开发，包括所谓的转化性研究（Translational Research）。""

近期论文

1. Xia R*, Wang N*, Xu Z*, Lu Y, Song J, Zhang A, Guo C, He Y#. Cryo-EM structure of the human histamine H 1 receptor/G q complex. Nat Commun. 2021 Apr 7;12(1):2086. doi: 10.1038/s41467-021-22427-2.
2. Lu Y*, Zhou XE*, Gao X, Wang N, Xia R, Xu Z, Leng Y, Shi Y, Wang G, Melcher K, Xu HE, He Y#. Crystal structure of heliorhodopsin 48C12. Cell Res. 2020 Jan;30(1):88-90. doi: 10.1038/s41422-019-0266-0. Epub 2019 Dec 26. PubMed PMID: 31879417; PubMed Central PMCID: PMC6951262.
3. Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H. A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell Res. 2019 Dec;29(12):971-983. doi: 10.1038/s41422-019-0256-2. Epub 2019 Nov 27. PubMed PMID: 31776446; PubMed Central PMCID: PMC6951264..
4. He Y *#, Shi J*, Nguyen QT*, You E, Liu H, Ren X, Wu Z, Li J, Qiu W, Khoo SK, Yang T, Yi W, Sun F, Xi Z, Huang X, Melcher K, Min B#, Xu HE#. Development of highly potent glucocorticoids for steroid-resistant severe asthma. PNAS，2019; 116(14):6932-6937.*, contribute equally.#, corresponding author.
5. Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. 2018; 560(7720):666-670.

2011/03-2017/12期间
6. Zhou XE*, He Y*, de Waal PW*, Gao X*, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell, 2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002. Cover article of Cell v170.
7. He Y#, Gao X, Goswami D， Hou L, Pal K, Yin Y, Zhao G, Ernst O.P, Griffin P, Melcher K, Xu HE#. Molecular Assembly of Rhodopsin with G-Protein Coupled Receptor Kinases. Cell Res. 2017 Jun;27(6):728-747. doi: 10.1038/cr.2017.72.
8. Yin Y, de Waal PW, He Y, Zhao LH, Yang D, Cai X, Jiang Y, Melcher K, Wang MW, Xu HE. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors. J Biol Chem. 2017; 292(24):9865-9881.
9. Ma H, Duan J, Ke J, He Y, Gu X, Xu TH, Yu H, Wang Y, Brunzelle JS, Jiang Y, Rothbart SB, Xu HE, Li J, Melcher K. A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Science advances. 2017; 3(6):e1601217.
10. Kang Y*, Zhou XE*, Gao X*, He Y*,Liu W, Ishchenko A, …Stevens RC, Cherezov V, Melcher K, Xu HE. Crystal structure of rhodopsin bound to arrestin determined by femtosecond X-ray laser. Nature. 2015 Jul 30;523(7562):561-7.
11. He Y#,Shi J, Yi W, Ren X, Gao X, Li J, Wu N, Weaver K, Xie Q, Khoo SK, Yang T, Huang X, Melcher K and Xu HE#. Discovery of a highly potent glucocorticoid for asthma treatment. Cell Disc 2015, 1. pii: 15035.
12. Zhi X, Zhou XE, He Y, Searose-Xu K, Zhang CL, Tsai CC, Melcher K, Xu HE. Structural basis for corepressor assembly by the orphan nuclear receptor TLX. Genes Dev. 2015 Feb 15;29(4):440-50.
13. He Y#,Yi W, Suino-Powell K, Zhou XE, Tolbert WD, Tang X, Yang J, Yang H, Shi J, Hou L, Jiang H, Melcher K, Xu HE#. Structures and mechanism for the design of highly potent glucocorticoids. Cell Res. 2014 Jun;24(6):713-26.
14. Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE. Structural insights into gene repression by the orphan nuclear receptor SHP. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44.
15. Jiang L, Liu X, Xiong G, Liu H, Chen F, Wang L, He Y. et al. DWARF 53 acts as a repressor of strigolactone signaling in rice. Nature, 2013, 504: 401-405.
16. Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MHE, Suino-Power KM, He Y, Xu Y, .Mecher K, Xu HE. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science. 2012 Jan 6;335(6064):85-8.
17. He Y#, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE#. Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Sci Signal. 2011 Jul 5;4(180):ra44. Cover article.