个人简历

现负责科研项目有：
1.【纳米材料对不同发育时期小鼠血糖代谢的影响及其机制的研究】
国家自然科学基金 2017-2020 负责人
2.【特定的转录因子重组蛋白质诱导成纤维细胞直接重编程为软骨细胞及其安全性的研究】
国家自然基金 2012-2016 负责人
3.【水环境中TiO2纳米颗粒对血糖代谢的影响极其机制的研究】
城市水资源与水环境国家重点实验室 2015-2016 负责人
4.【转录因子重组蛋白改善间充质干细胞增殖能力的研究】
黑龙江省归国留学基金 2012-2015 负责人
5.【水环境中的纳米粒子对内分泌系统的毒理效应及其机制的研究】
城市水资源与水环境国家重点实验室 2011-2014 负责人
6.【关于改善重组蛋白诱导iPS细胞效率的研究】
国家自然科学基金 2011-2011 负责人
工作经历
2016.1-2010.1-2015.12
哈尔滨工业大学 生命科学与技术学院 教授
哈尔滨工业大学 生命科学与技术学院 副教授
2009.4-2010.1
日本 产业技术综合研究所 研究员
2007.4-2009.3
日本 京都大学 学术振兴会（JSPS）研究员
教育经历
2004.4-2007.3 日本　京都大学　　　 博士
2002.4-2004.3 日本　京都大学　　　 硕士
1998.4-2002.3 日本　京都教育大学　 学士
授权专利
1) 顾宁, 胡海龙, 毛轲, 郭倩. 一种促进肌肉细胞中GLUT4基因表达的方法: ZL2014 10076511.1. 2016-09-07.
2) 顾宁, 岳磊，胡海龙, 郭倩, 毛轲. SB505124在制备治疗软骨损伤的药物中的应用: ZL2014 10200906.8. 2016-01-27.
3) 顾宁, 岳磊, 胡海龙. 一种提高人间充质干细胞分化能力的方法: ZL2014 10264739.3. 2016-08-24.
4) 顾宁, 马卓, 胡海龙, 郭倩. 一种检测脏器组织中是否存在纳米颗粒的方法: ZL2014 10465607.7. 2017-01-04.
科研项目
【特定的转录因子重组蛋白质诱导成纤维细胞直接重编程为软骨细胞及其安全性的研究】
【转录因子重组蛋白改善间充质干细胞增殖能力的研究】
【水环境中的纳米粒子对内分泌系统的毒理效应及其机制的研究】
【关于改善重组蛋白诱导iPS细胞效率的研究】
纳米材料对不同发育时期小鼠血糖代谢的影响及其机制的研究
水环境中 TiO2纳米颗粒对血糖代谢的影响极其机制的研究
团队成员
胡海龙：博士, 研究方向: 纳米毒理与内分泌系统疾病.
郭 倩：博士, 研究方向: UPR信号通路参与棕榈酸诱导的musclin基因表达的初步研究.
周 莹：硕士, 研究方向: 葡萄糖胺调控Musclin、CTRP15及FNDC5基因表达及机制的初步研究
闫玉恒：硕士, 研究方向: 糖尿病机制研究.
宗 贺：硕士, 研究方向: 糖尿病机制研究.
讲授课程
《生物制品》
研究生学位课，了解生物制品的制备方法和基本要求，掌握生物制品制备的基本原理及制备技术，了解生物制品领域的最新进展及发展趋势。
《生命科学基础与应用》
校管核心课课，旨在扩大学生的知识面，培养学生生命科学的思维方式，将生命科学的思想、方法运用到他们所从事的工作领域。
《纳米技术与基因研究》
新生研讨课，以纳米技术在基因领域的研究为重点，讲授纳米技术在基因靶向医疗、基因检测诊断等领域的最新研究进展，与同学们共同分析存在的科学问题及解决方法，探讨纳米技术在生命医学领域的未来发展方向与前景。
招生信息
招收硕士：1-2名
招收博士：1名

研究领域

1. 糖尿病、肥胖症等内分泌疾病相关基因功能的研究
2. 纳米粒子、小分子化合物的药理及毒理研究
3. 环境污染物对健康影响及分子机制研究"干细胞的增殖与分化机制、体细胞重编程等研究
糖尿病，肥胖症等内分泌疾病的发病机制和治疗方法的研究
纳米粒子及小分子化合物的药理研究"

近期论文

Hailong Hu, Qian Guo, Xingpei Fan, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Ning Gu. Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice. Nanotoxicology. 2020 Feb;14(1):59-76.
Hailong Hu, Boya Zhang, Li Li, Qian Guo, Daqain Yang, Xiangjuan Wei , Xingpei Fan, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Changlin Wang, Liping Hou, Ning Gu. The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice. Environ Toxicol. 2020 Apr;35(4):443-456.
Qian Guo, Hailong Hu, Xiaohuan Liu, DaQian Yang, Yao Yin, Boya Zhang, Hongjuan He, Yuri Oh, Qiong Wu, Chuanpeng Liu, Ning Gu. C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1081-E1092.
Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Ning Gu. Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species.Particle and Fibre Toxicology.2019, Vol.16:41.
Qian Guo，Hailong Hu，Ying Zhoua，Yuheng Yan，Xiangjuan Wei，Xingpei Fan，Daqian Yang，Hongjuan He，Yuri Oh，Kun Chen，Qiong Wu，Chuanpeng Liu，Ning Gu.Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells. Food Chem Toxicol, 2019 March; 125: 95-105.
Hailong Hu, Xingpei Fan, Yao Yin, Qian Guo, Daqian Yang, Xiangjuan Wei, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Kun Chen, Yujie Feng, Liping Hou, Li Li, Ning Gu. Mechanisms of titanium dioxide nanoparticle-induced oxidative stress and modulation of plasma glucose in mice. Environ Toxicol. 2019 Nov;34(11):1221-1235.
Qian Guo, Xiangjuan Wei, Hailong Hu, Daqian Yang, Boya Zhang, Xingpei Fan, Jing Liu, Hongjuan He, Yuli Oh, Qiong Wu, Yao Zhang, Chuanpeng Liu, Changlin Whang, Ning Gu. The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes. Biochemical and Biophysical Research Communications. Vol. 520(3):619-626, 2019.
Hu Hailong, Li Li, Guo Qian, Zong He, Yan Yuheng, Yin Yao, Wang Yu, Oh, Yuri, Feng Yujie, Wu Qiong, Ning Gu. RNA sequencing analysis shows that titaniumdioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology, 2018 May;12(4):341-356.
Guo Qian, Jin Sanli, Hu Hailong, Zhou Ying, Yan Yuheng, Zong He, Wang Yu, He Hongjuan, Oh Yuli, Liu Chuanpeng, Ning Gu. Hypoxia in 3T3-L1 adipocytes suppresses adiponectin expression via the PERK and IRE1 unfolded protein response. Biochem Biophys Res Commun. 2017 Nov 4;493(1):346-351.
Hu Hailong, Li Li, Guo Qian, Jin Sanli, Zhou Ying, Oh Yuri, Feng Yujie, Wu Qiong, Ning Gu. A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice. Food Chem Toxicol, 2016, 95:175-187.
Gu Ning, Hu Hailong, Guo Qian, Jin Sanlin, Wang Changlin, Oh Yuri, Feng Yujie, Wu Qiong, Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food Chem Toxicol, 2015, 86:124-131.
Gu Ning, Guo Qian, Mao Ke, Hu Hailong, Jin Sanlin, Zhou Ying, He Hongjuan, Oh Yuri, Liu Chuanpeng, Wu Qiong, Plasmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes. Biochem Biophys Res Commun, 2015, 467: 521-526.
Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning. Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice. J. App. Toxicol. 2015.
Hu Hailong, Li Li, Wang Changlin, He Hongjuan, Mao Ke, Ma Xiao, Shi Ruoyu, Oh Yuri, Zhang Fengwei, Lu Ying, Wu Qiong, Gu Ning. 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33(6):1899-910.
Wang CL, Diao YX, Xiang Q, Ren YK, Gu Ning. Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice. Eur J Pharmacol. 2014 Sep 5;738:1-7.
Wang CL, Xiang Q, Diao YX, Ren YK, Gu Ning. Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice. Eur J Pain. 2014 Sep;18(8):1157-64.
Wang CL, Ren YK, Xiang Q, Wang Y, Gu Ning, Lu C, Wang R, Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides. 2013 Oct;47(5):297-304.
Ikegami Dasuke, Iwai T, Ryo Senyi, Gu Ning, Sugiyama Tasuke, Oh Isamu, Yoshikawa Hiroyuki, Tsumaki Nobuyuki. Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage. Osteoarthritis Cartilage. 19(2), 233-41 2011.
Gu Ning, Nagatomo Fumiko, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Effects of hyperbaric oxygenation on oxidative capacity in the soleus and plantaris muscles of type 2 diabetic rats. Diabetes Technol. Ther. 12(2):125-133, Feb, 2010.
Gu Ning, Tsuda Mariko, Matsunaga Tetsuro, Adachi Tetsuya, Yasuda Koichiro, Ishihara Akihiko, Tsuda Kinsuke. Glucose regulation of DPP-IV gene expression is mediated by HNF-1alpha in epithelial intestinal cells. Clin Exp Pharm Phys. 35(12), 1433-1439, May, 2008.
Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Ya
suda Koichiro, Tsuda Kinsuke. HNF-1alpha participates in glucose regulation of sucrase-isomaltase (SI) gene expressions in small intestinal epithelial cells. Biochem Biophys Res Commun. 353(3), 617-622, Feb, 2007.
Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Takeda Jun, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. Biochem Biophys Res Commun. 346(3), 1016-1023, Aug, 2006.
Gu Ning, Adachi Tetsuya, Takeda Jun, Aoki Norihiko, Tsujimoto Gozoh, Ishihara Akihiko, Tsuda Kinsuke, Yasuda Koichiro. Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells. J Nutrl Sci Vitaminol. 52(2), 105-112, Apr, 2006.
Gu Ning, Suzuki Naoko, Takeda Jun, Adachi Tetsuya, Tsujimoto Gozoh, Ishihara Akihiko,Tsuda Kinsuke, Yasuda Koichiro. Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase (SI) in Caco-2 cells. Biochem Biophys Res Commun. 325(1), 308-313, Oct, 2004.