研究领域

蛋白质降解通路、早期发育相关因子及通路调控肿瘤及免疫相关疾病的作用及机制。蛋白质降解通路在早期发育过程中的调控作用及机制。

近期论文

1. Ali A, Wang Z, Fu J, Ji L, Liu J, Li L, Wang H, Chen J, Caulin C, Myers JN, Zhang P, Xiao J*, Zhang B*, Li X. Differential regulation of the REGγ-proteasome pathway by p53/TGFβ signaling and mutant p53 in cancer cells. Nat Commun. 4:2667, 2013 IF=10.015 2. Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q, Liu J, Wang W, Ji L, Shan P, Wang Y, Yang Y, Jung SY, Zhang P, Wang C, Long W, Zhang B*, Li X*.Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions.J Biol Chem. 288(23):16567-78, 2013. IF=4.651 3. Zhang B*, Liu X, Chen W, Chen L. IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways. Acta Biochim Biophys Sin.; 45(10):867-74, 2013. IF=1.807 4. Zhang B*, Liu J, Zhou Q, Zuo D, Wang Y. Analysis of differentially expressed genes in ductal carcinoma with DNA microarray. Eur Rev Med Pharmacol Sci. 17: 758-766, 2013. IF=1.093 5. Zhang B#, Li M#, Chen L, Yang K, Shan Y, Zhu L, Sun S, Li L, Wang C. The TAK1-JNK cascade is required for IRF3 function in the innate immune response. Cell Res 2009; 19 (4):412-28 IF=4.535 6. Diao L#, Zhang B#, Xuan C, Sun S, Yang K, Tang Y, Qiao W, Chen Q, Geng Y, Wang C. Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0. Exp Cell Res 2005; 308 (1): 196-210. 1. Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J*, O'Malley BW*, Li X*. REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 110(27):11005-10, 2013. IF=9.737 2. Li L, Zhang P, Wei H, Wang W, Yao L, Li Y, Zhou L, Wang Z, Liu J, Zhou L, Amjad A, Zhang B, Jing T, Xiao J, Dang Y, Li X. REGγ Mediated Regulation of p21Waf/Cip1, p16INK4a and p14ARF/p19ARF in Vivo. Journal of Cancer Therapy, 4, 933-938, 2013. 3. Wu Y, Wang L, Wang G, Zhou P, Zeng Y, Zhao Y, Wang Y, Liu J, Zhang B, Luo H, Li X. Regulation of REGγcellular distribution and function by SUMO modification. Cell Res. 21(5):807-16, 2011. IF=8.151 4. Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Liu J, Li L, Zeng Y, Dang Y, Wang C, Gao G, Long W, Lonard DM, Qiao S, Tsai MJ, Zhang B, Luo H, Li X. REGγmodulates p53 activity by regulating its cellular localization. J Cell Sci. 2010;123 (Pt23), 4076-84. IF=6.144 5. Feng D, Mei Y, Wang Y, Zhang B, Wang C, Xu L. Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-kappaB activation. Immunol Lett. 2008; 121(2):127-33. IF=2.858 6. Sun S, Tang Y, Lou X, Zhu L, Yang K, Zhang B, Shi H, Wang C. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. J Cell Biol 2007; 178 (2): 231-44. IF=10.152 7. Yang K, Shi H, Qi R, Sun S, Tang Y, Zhang B, Wang C. Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell 2006; 17 (3): 1461-71. IF=6.562 8. Zhang L, Tian B, Diao L, Xiong Y, Tian S, Zhang B, Li W, Ren H, Li Y, Ji J. Dominant expression of 85-kDa form of cortactin in colorectal cancer. J Cancer Res Clin Oncol. 2006;132(2):113-20. IF=2.469