个人简历

教育经历\r
2007-2012 瑞士苏黎世联邦理工学院(ETH Zurich) 博士\r
2004-2007 华东师范大学 硕士\r
2000-2004 宁波大学 本科\r
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工作经历\r
2014--至今 华东师范大学 研究员、博导\r
2012-2013 瑞士苏黎世联邦理工学院(ETH Zurich) 博士后

研究领域

"""""叶海峰博士主要从事合成生物学与生物医学工程领域的研究。主要聚焦于针对重大代谢疾病和肿瘤的精准化、智能化的基因治疗和细胞治疗。利用合成生物学的理念和方法对细胞进行遗传学改造和重编程。重新设计、构建智能基因网络调控系统用于疾病的精准治疗。主要研究内容包括：人工基因线路和定制细胞的设计与构建、光遗传学与疾病精准治疗、精准可控基因编辑体系、代谢疾病智能诊疗、肿瘤免疫智能诊疗、合成生物学与再生医学、微生物合成生物学与智能诊疗等。"

近期论文

Yi Wang#, Shu Liao#, Ningzi. Guan, Yuanxiao. Liu, Kaili. Dong, Wilfried Weber, Haifeng Ye*. A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate. Science Advances 2020, 6, eabb9484.DOI: 10.1126/sciadv.abb9484\r
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Jiali Wu#, Meiyan Wang#, Xueping Yang#, Chengwei Yi, Jian Jiang, Yuanhuan Yu，Haifeng Ye*. A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice. Nature Communications 2020 Jul 24;11(1):3708. doi: 10.1038/s41467-020-17530-9.\r
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Yuanhuan Yu, Xin Wu, Ningzi Guan, Jiawei Shao, Huiying Li, Yuxuan Chen, Yuan Ping, Dali Li and Haifeng Ye*. Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors. Science Advances 2020, Vol. 6, no. 28, eabb1777 DOI: 10.1126/sciadv.abb1777\r
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Krzysztof Krawczyk, Shuai Xue, Peter Buchmann, Ghislaine Charpin-El-Hamri, Pratik Saxena, Marie-Didiée Hussherr, Jiawei Shao, Haifeng Ye, Mingqi Xie, Martin Fussenegger*. Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice. Science, 2020 May 29;368(6494):993-1001. doi: 10.1126/science.aau7187.\r
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Jianli Yin, Linfeng Yang, Lisha Mou, Kaili Dong, Jian Jiang, Shuai Xue, Ying Xu, Xinyi Wang, Ying Lu, Haifeng Ye*. A green tea–triggered genetic control system for treating diabetes in mice and monkeys. Science Translational Medicine, 2019 Oct 23. doi: 10.1126/scitranslmed.aav8826. (Cover story)\r
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Jiawei Shao, Meiyan Wang, Guiling Yu, Sucheng Zhu, Yuanhuan Yu, Boon Chin Heng, Jiali Wu, Haifeng Ye*. Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Proc Natl Acad Sci USA, 2018 Jul 17. doi: 10.1073/pnas.1802448115.\r
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Ying Liu, Ghislaine Charpin-EI Hamri, Haifeng Ye, Martin Fussenegger*. A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice. Nucleic Acids Res. 2018 Oct 12. doi: 10.1093/nar/gky805.\r
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Ying Liu, Peng Bai, Anne-Kathrin Woischnig, Ghislaine Charpin-El Hamri, Haifeng Ye, Marc Folcher, Mingqi Xie, Nina Khanna, Martin Fussenegger*. Immunomimetic Designer Cells Protect Mice from MRSA Infection. Cell. 2018 Jul 12. doi:10.1016/j.cell.2018.05.039. Epub 2018 Jun 21.\r
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Jiawei Shao, Shuai Xue, Guiling Yu, Yuanhuan Yu, Xueping Yang, Yu Bai, Sucheng Zhu, Linfeng Yang, Jianli Yin, Yidan Wang, Shuyong Liao, Sanwei Guo, Mingqi Xie, Martin Fussenegger, Haifeng Ye*. Smartphone-controlled opto-genetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice. Science Translational Medicine,2017 Apr 26. doi: 10.1126/scitranslmed.aal2298.eaal2298 (2017) (Cover story)\r
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Shuai Xue, Jianli Yin, Jiawei Shao, Yuanhuan Yu, Linfeng Yang,Yidan Wang, Mingqi Xie, Martin Fussenegger and Haifeng Ye*. A synthetic biology-inspired therapeutic strategy for targeting and treating hepatogenous diabetes.Molecular Therapy. 2017 Feb 1. doi: 10.1016/j.ymthe.2016.11.008. (corresponding author)\r
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Haifeng Ye* †, Mingqi Xie†, Shuai Xue, Ghislaine Charpin-El Hamri, Jianli Yin, Henryk Zulewskiand Martin Fussenegger*. Self-adjusting synthetic gene circuit for correcting insulin resistance. Nature Biomedical Engineering. 2017 Jan.doi: 10.1038/s41551-016-0005. (co-first and co-corresponding author)\r
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Mingqi Xie, Haifeng Ye, Hui Wang, Ghislaine Charpin-El Hamri, Claude Lormeau, Pratik Saxena, Jörg Stelling* and Martin Fussenegger*. β-cell-mimetic designer cells provide closed-loop glycemic control. Science. 2016 Dec. doi: 10.1126/science.aaf4006\r
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Peng Bai, Haifeng Ye, Mingqi Xie, Pratik Saxena, Henryk Zulewski, Ghislaine Charpin-El Hamri, Valentin Djonovand，Martin Fussenegger*, A synthetic biology-based device prevents liver injury in mice.Journal of Hepatology. 2016 Jul. doi: 10.1016/j.jhep.2016.03.020.\r
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Wang H, Haifeng Ye, Xie M, Daoud El-Baba M, Fussenegger M*.Cosmetics-triggered percutaneous remote control of transgene expression in mice. Nucleic Acids Res. 2015 Aug 18;43(14):e91. doi: 10.1093/nar/gkv326.\r
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Mingqi Xie, Haifeng Ye, Hamri GC, Martin Fussenegger*. Antagonistic control of a dual-input mammalian gene switch by food additives.Nucleic Acids Res. 2014 Aug;42(14):e116. doi: 10.1093/nar/gku545.\r
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Haifeng Ye, Charpin-El Hamri, G., Zwicky, K., Christen, M., Marc Folcher, Martin Fussenegger*. Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. Proc Natl Acad Sci USA. 2013 Jan 2;110(1):141-6. doi: 10.1073/pnas.1216801110.\r
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Haifeng Ye,Daoud-El Baba, M., Peng, R.W. & Martin Fussenegger*. A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science. 2011 Jun 24;332(6037):1565-8. doi: 10.1126/science.1203535.\r
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Haifeng Ye, Jin L, Hu R, Yi Z, Li J, Wu Y, Xi X, Wu Z*. Poly(gamma,L-glutamic acid)-cisplatin conjugate effectively inhibits human breast tumor xenografted in nude mice. Biomaterials. 2006 Dec;27(35):5958-65.