个人简历

国家杰出青年基金获得者，科技部中青年科技创新领军人才，Clarivate Analytics（科睿唯安）全球高被引科学家（2019）\r
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1. 教育经历：\r
1997/9 - 2002/6，南京工业大学，材料学（专业方向），博士学位\r
1993/9 - 1997/7，齐鲁工业大学，材料学（专业方向），学士学位\r
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2. 工作经历：\r
2020/3 - 至今， 复旦大学 材料科学系，教授（二级）、博士生导师\r
2017/9 - 2020/2 上海市绿色化学与化工过程绿色化重点实验室，常务副主任\r
2016/3 - 2020/2 华东师范大学 化学与分子工程学院，教授（二级）、博士生导师\r
2011/10 - 2016/2 高性能陶瓷和超微结构国家重点实验室，副主任\r
2010/2 - 2010/08 昆士兰大学（The University of Queensland），高级研究学者\r
2008/9 - 2016/2，中国科学院上海硅酸盐研究所，研究员、博士生导师\r
2005/7 - 2008/8，中国科学院上海硅酸盐研究所，副研究员、硕士生导师\r
2004/8 - 2005/6，中国科学院上海硅酸盐研究所，助理研究员\r
2002/8 - 2004/8，中国科学院上海硅酸盐研究所，博士后科研人员\r
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3. 主要学术任职（兼职）：\r
中国科学院上海硅酸盐研究所兼职教授，复旦大学附属华山医院客座教授；中国生物材料学会影像材料与技术分会副主任委员、中国生物材料学会理事、中国生物材料学会纳米生物材料分会常务委员、中国生物医学工程学会生物材料分会委员、中国材料学会特种陶瓷分会理事、中国硅酸盐学会薄膜与涂层分会理事、中国研究型医院学会消化内镜分子影像学专业委员会常务委员；国际学术期刊“Bioconjugate Chemistry”、“Recent Patents on Materials Science”、“American Journal of Nuclear Medicine and Molecular Imaging”、“Reviews in Nanoscience and Nanotechnology”等编委。\r
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4. 主要获奖和荣誉：\r
•\t2019年，入选 Clarivate Analytics（科睿唯安）全球高被引科学家 \r
•\t2017年，入选“国家自然科学基金委杰出青年科学基金项目”\r
•\t2017年，入选“科技部中青年科技创新领军人才计划”\r
•\t2016年，入选“上海市优秀学术带头人计划” \r
•\t2012年，入选“上海市青年科技启明星跟踪计划”\r
•\t2012年，入选“上海市人才发展资金计划”\r
•\t2012年，获“中国科学院上海分院第三届杰出青年科技创新人才提名奖”\r
•\t2008年，获“第五届柳大纲优秀青年科技奖”\r
•\t2007年，入选“上海市青年科技启明星计划（A类）”\r
•\t2004年，获“国防科学技术二等奖”（排名第三）\r
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5. 主持科研项目及人才计划项目情况：\r
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国家自然科学基金委项目（7项）\r
(1) 国家自然科学基金杰出青年项目，51725202，稀土功能材料，2018/01-2022/12，400万元，在研，主持。\r
(2) 国家自然科学基金面上项目，51872094，铁基多元异质结材料用于肿瘤化学动力学疗法的研究，2019/01-2022/12，60万元，在研，主持。\r
(3) 国家自然科学基金面上项目，51372260，用于高效跨越脑胶质瘤血脑屏障的新型多功能纳米诊疗剂的实验研究，2014/01-2017/12，80万元，已结题，主持。\r
(4) 国家自然科学基金专项，50823007，复合氧化物纳米结构的合成与生物学效应，2009/01-2012/12，140万元，已结题，主持。\r
(5) 国家自然科学基金面上项目，50972154，基于乳腺癌诊治技术的新型多功能复合结构设计制备与初步应用探索，2010/01-2012/12，36万元，已结题，主持。\r
(6) 国家自然科学基金面上项目，50672115，基于低维纳米结构单元的镧系化合物复杂微／纳米结构的构筑及光学性能的研究，2007/01-2009/12，29万元，已结题，主持。\r
(7) 国家自然科学基金面上项目，50502037，基于一维纳米核@壳结构的稀土磷酸盐高效发光材料的研究，2006/01-2006/12，9万元，已结题，主持。\r
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上海市科委项目（3项）：\r
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(1) 上海市基础研究重大研究计划，19JC1412000，化学动力学疗法的材料学基础，2019/10-2022/09，400万元，在研，主持。\r
(2) 上海市纳米技术专项（重点），11nm0505000，新型多功能肿瘤探针及其应用于HER-2阳性乳腺癌诊治的研究，2011/09-2014/10，50万元，已结题，主持。\r
(3) 上海市纳米技术专项（重点），0852nm03900，用于胶质瘤早期诊断的新型荧光/磁共振双功能纳米探针的研究，2008/09-2010/10，40万元，已结题，主持。\r
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人才计划资助项目（4项）：\r
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(1) 上海市优秀学术带头人计划，16XD1604000，新型稀土功能材料用于乏氧肿瘤高效诊疗的研究，2016/07-2019/06，40万元，已结题，主持。\r
(2) 上海市青年科技启明星计划（跟踪类），12QH1402500，兼具肿瘤多模态成像和光控治疗的新型多功能纳米诊疗剂的实验研究，2012/09-2014/10，20万元，已结题，主持。\r
(3) 上海市人才发展资金资助计划，2012035，基于肿瘤高效诊疗的新型多功能纳米诊疗剂的实验研究，2012/09-2014/10，10万元，已结题，主持。\r
(4) 上海市青年科技启明星计划（A类），07QA14061，基于新型核壳结构的磁控靶向性/荧光标记复相纳米晶（g-Fe2O3@LnPO4）的可控合成及性能研究，2007/09-2009/10，13万元，已结题。主持。\r
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6. 主要学术创新贡献：\r
近年来，稀土功能材料作为一类新型生物医用材料，在临床医学研究中备受关注。因此，从稀土功能材料的结构设计和化学制备角度出发，拟解决临床医学中“多模态影像与多功能肿瘤治疗的高效融合”关键科学问题，已成为材料学、化学、药学、生物医学等多学科交叉领域前沿课题。\r
近五年内，围绕“多模态影像与多功能肿瘤治疗的高效融合”关键科学问题，步文博在新型稀土功能材料的设计与制备及生物应用中，做出了系统性创新工作：（1）揭示了稀土无机影像探针的磁共振影像机理，构建了基于稀土功能材料的系列新型多模态影像探针，实现了单一探针的结构影像和功能影像的高效融合与协同增强成像。（2）发现了稀土功能材料的“放疗增敏效应”，提出了“克服乏氧、利用乏氧、规避乏氧”三类材料设计策略，实现了精准影像介导下的多功能协同增强的乏氧肿瘤高效治疗；（3）提出了“化学动力学疗法”和“离子干扰疗法”新概念，拓展了无机功能材料用于“肿瘤饥饿疗法”新思路，实现了基于肿瘤微环境特异性诱导激活的高效治疗。该系列研究为解决“常规医学影像探针性能低、常规肿瘤治疗技术（化疗、放疗）固有缺陷”等临床医学瓶颈问题提供了新的研究思路。\r
近六年内，步文博作为通讯作者共发表SCI学术论文72篇，其中：SCI影响因子大于10.0的论文68篇，包括：Nature Nanotechnology（1篇）、Chem.（1篇）、Science Advances（2篇）、J. Am. Chem. Soc.（6篇）、Angew. Chem. Int. Ed.（8篇）、Adv. Mater.（5篇）等国际著名SCI学术期刊；受邀著名综述类学术期刊Acc. Chem. Res.、Chem. Rev.、Chem. Soc. Rev.等撰写了5篇专题综述论文，论文SCI他引10500余次，入选Clarivate Analytics（科睿唯安）全球高被引科学家（2019）；其中，1篇研究论文入选“2012年中国百篇最具影响国际学术论文”，18篇研究论文入选 ESI “Highly Cited Papers”，10篇研究论文被 Nature/SciBX、Chemical& Engineering News、ChemistryViews、Asian Scientist、ChemistryWorld、Phys.org等国际著名专业新闻媒体作为研究亮点进行了专题报道和评述。获授权中国发明专利多项。\r

研究领域

"""""稀土生物化学与医用功能材料（物理化学、应用化学）：\r
1. 新型光电磁功能材料的化学合成方法学研究\r
2. 稀土功能材料的光磁学、分子影像学与疾病（肿瘤）高效诊疗研究\r
3. 新型多功能材料用于脑神经显像与智能调控研究"

近期论文

1. Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.\r
Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.\r
Nature Nanotechnology, 2017, 12 (4), 378-386. （SCI-IF：31.538）\r
2. Jianan Liu, Wenbo Bu*, Jianlin Shi*.\r
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.\r
Chemical Reviews, 2017, 117(9): 6160-6224. (Invited Review) （SCI-IF：52.758）\r
3. Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.\r
Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.\r
Chemical Society Reviews, 2017, 46, 7438–7468. (Invited Review) （SCI-IF：42.846）\r
4. Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu*\r
Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.\r
Accounts of Chemical Research, 2018, 51(10), 2502-2511. (Invited Review) （SCI-IF：20.835）\r
5. Jianan Liu, Wenbo Bu*, Jianlin Shi*.\r
Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.\r
Accounts of Chemical Research, 2015, 48 (7): 1797–1805. (Invited Review). （SCI-IF：20.832）\r
6. Yanyan Liu, Xianfu Meng, Wenbo Bu*.\r
Upconversion-based Photodynamic Cancer Therapy.\r
Coordination Chemistry Reviews, 2019, 379, 82-98. (Invited Review) （SCI-IF：15.367）\r
7. Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* and Wenbo Bu*\r
Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.\r
Chem, 2019, 5 (8): 2171-2182. （SCI-IF：19.735）\r
8. Jianan Liu, Limin Pan, Chunfeng Shang, Bin Lu, Rongjie Wu, Yun Feng, Weiyu Chen, Rongwei Zhang, Jiwen Bu, Zhiqi Xiong, Wenbo Bu*, Jiulin Du,* and Jianlin Shi*\r
A highly sensitive and selective nanosensor for near-infrared potassium imaging\r
Science Advances, 2020, 6, eaax9757.（SCI-IF：13.116）\r
9. Yaqin Jiang, Pengfei Fu, Yanyan Liu*, Chaochao Wang, Peiran Zhao, Xu Chu, Xingwu Jiang, Wei Yang, Yelin Wu, Ya Wang, Guohua Xu*, Jin Hu, Wenbo Bu*\r
Near-infrared Light-Triggered NO Release for Spinal Cord Injury Repair.\r
Science Advances, 2020, 6, abc3513. (Just Accepted)（SCI-IF：13.116）\r
10. Jianan Liu, Rongwei Zhang, Chunfeng Shang, Yu Zhang, Yun Feng, Limin Pan, Bing Xu, Taeghwan Hyeon, Wenbo Bu*, Jianlin Shi* and Jiulin Du*\r
Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.\r
Journal of the American Chemical Society, 2020, DOI: 10.1021/jacs.0c01025.（SCI-IF：14.612）\r
11. Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*\r
Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.\r
Journal of the American Chemical Society, 2019, 141 (2), 849-857. （SCI-IF：14.612）\r
12. Chen Zhang, Wenbo Bu*, Dalong Ni, Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.\r
A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.\r
Journal of the American Chemical Society, 2016, 138 (26), 8156–8164. （SCI-IF：14.612）\r
13. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.\r
Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.\r
Journal of the American Chemical Society, 2014, 136 (27), 9701–9709. （SCI-IF：14.612）\r
14. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.\r
A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.\r
Journal of the American Chemical Society, 2013, 135 (35), 13041-13048 （SCI-IF：14.612）\r
15. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.\r
Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.\r
Journal of the American Chemical Society, 2013, 135 (17), 6494-6503. （SCI-IF：14.612）\r
16. Ruixue Song, Han Wang, Meng Zhang, Yanyan Liu, Xianfu Meng, Shaojie Zhai, Chaochao Wang, Teng Gong, Yelin Wu, Xingwu Jiang, Mingyuan He, Wenbo Bu*\r
Near-infrared Light-triggered Chlorine Radicals (•Cl) Stress for Cancer Therapy\r
Angewandte Chemie-International Edition, 2020, 10.1002/anie.202007434（SCI-IF：12.959）.\r
17. Yanli Li, Peiran Zhao, Teng Gong*, Meng Zhang, Hui Cheng, Yanyan Liu, Yelin Wu*, Wenbo Bu*. \r
Redox Dyshomeostasis Strategy for Hypoxia Tumor Therapy.\r
Angewandte Chemie-International Edition, 2020, Manuscript number: 202003653R1 (In Revision)（SCI-IF：12.959）.\r
18. Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.\r
Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.\r
Angewandte Chemie-International Edition, 2019, 58 (4), 946-956. （SCI-IF：12.959）\r
19. Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*\r
Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.\r
Angewandte Chemie-International Edition, 2016, 55, 2101-2106. （SCI-IF：12.959）\r
20. Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.\r
X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.\r
Angewandte Chemie-International Edition, 2015, 54, 14026–14030. （SCI-IF：12.959）\r
21. Yanyan Liu, Yong Liu, Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.\r
Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.\r
Angewandte Chemie-International Edition, 2015, 54, 8105–8109. （SCI-IF：12.959）\r
22. Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.\r
Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.\r
Angewandte Chemie-International Edition, 2015, 54: 1770–1774. （SCI-IF：12.959）\r
23. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.\r
Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．\r
Angewandte Chemie-International Edition, 2014, 53, 4551-4555. （SCI-IF：12.959）\r
24. Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.\r
NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.\r
Angewandte Chemie-International Edition, 2013, 52, 4375-4379. （SCI-IF：12.959）\r
25. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin Lv, Han Wang, Dayong Jin, Wenbo Bu*\r
Biodegradable Nanoprodrugs: Delivering ROS To Cancer Cells For Molecular Dynamics Therapy.\r
Advanced Materials, 2020, 32, 1904011（SCI-IF：27.398）\r
26. Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.\r
Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy.\r
Advanced Materials, 2017, 29, 1701683. （SCI-IF：27.398）\r
27. Wenpei Fan, Wenbo Bu*, Jianlin Shi\r
On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles. \r
Advanced Materials, 2016, 28, 3987–4011.（SCI-IF：27.398）\r
28. Wenpei Fan, Wenbo Bu*, Bo Shen, Qianjun He, Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.\r
Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.\r
Advanced Materials, 2015, 27, 4155–4161. （SCI-IF：27.398）\r
29. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.\r
Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．\r
Advanced Materials, 2014, 26, 3867–3872. （SCI-IF：27.398）\r
30. Xianfu Meng, Hua Zhang, Meng Zhang, Baoming Wang, Yanyan Liu, Yan Wang, Xiangming Fang*, Jiawen Zhang, Zhenwei Yao*, Wenbo Bu*\r
Negative CT contrast agents for the diagnosis of malignant osteosarcoma.\r
Advanced Science, 2019, 6, 1901214. （SCI-IF：15.840）\r
31. Weiwei Su, Han Wang, Tao Wang, Xiao Li, Zhongmin Tang, Shuai Zhao, Meng Zhang, Danni Li, Xingwu Jiang, Teng Gong, Wei Yang, Changjing, Zuo*, Yelin Wu*, Wenbo Bu*.\r
Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.\r
Advanced Science, 2020, DOI: 10.1002/advs.201903585（SCI-IF：15.840）\r
32. Xiaoyan Chen, Huilin Zhang, Meng Zhang, Peiran Zhao, Ruixue Song, Teng Gong, Yanyan Liu*, Xinhong He*, Kuaile Zhao, and Wenbo Bu*\r
Amorphous Fe–based Nanoagents for Self–enhanced Chemodynamic Therapy by Re-establishing Tumor Acidosis.\r
Advanced Functional Materials 2020, 1908365. (DOI: 10.1002/adfm.201908365) （SCI-IF：16.836）\r
33. Aijun Shen, Xianfu Meng, Xiaolong Gao, Xiaowen Xu, Chulun Shao, Zhongmin Tang, Yanyan Liu, Wenbo Bu*, and Peijun Wang*\r
Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under 3.0T Magnetic Field.\r
Advanced Functional Materials 2019, 29, 1803832. （SCI-IF：16.836）\r
34. Yingying Jin, Dalong Ni, Lu Gao, Xianfu Meng, Yi Lv, Fang Han, Hua Zhang, Yanyan Liu, Zhenwei Yao, Xiaoyuan Feng, Wenbo Bu,* Jiawen Zhang*.\r
Harness the Power of Upconversion Nanoparticles for Spectral Computed Tomography Diagnosis of Osteosarcoma. \r
Advanced Functional Materials 2018, 28, 1802656. （SCI-IF：16.836）\r
35. Dalong Ni, Wenbo Bu,* Shengjian Zhang, Xiangpeng Zheng, Ming Li, Huaiyong Xing, Qingfeng Xiao, Yanyan Liu, Yanqing Hua, Liangping Zhou, Wenjun Peng, Kuaile Zhao, Jianlin Shi*.\r
Single Ho3+-Doped Upconversion Nanoparticles for High-Performance T2-Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging. \r
Advanced Functional Materials 2014, 24, 6613-6620. （SCI-IF：16.836）\r
36. Feng Chen, Wenbo Bu*, Shengjian Zhang, Jianan Liu, Wenpei Fan, Liangping Zhou, WeijunPeng, Jianlin Shi*.\r
Gd3+-Ion-Doped Upconversion Nanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization\r
Advanced Functional Materials, 2013, 23, 298-307. （SCI-IF：16.836）\r
37. Feng Chen, Wenbo Bu*, Shengjian Zhang, Huaiyong Xing, Jianan Liu, Qingfeng Xiao, Xiaohang Liu, Liangping Zhou, Weijun Peng, Lianzhou Wang, Jianlin Shi*.\r
Positive and Negative Lattice Shielding Effects Co-existing in Gd (III) Ion Doped Bifunctional Upconversion Nanoprobes.\r
Advanced Functional Materials 2011, 21, 4285-4294. （SCI-IF：16.836）\r
38. Teng Gong, Yanli Li, Bin Lv, Han Wang, Yanyan Liu*, Yelin Wu, Xingwu Jiang, Hongbo Gao, Xiangpeng Zheng*, Wenbo Bu*.\r
Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks.\r
ACS Nano, 2020, 14(3), 3032-3040.（SCI-IF：14.588）\r
39. Chulun Shao, Aijun Shen, Meng Zhang, Xianfu Meng, Chaolin Song, Xiaolong Gao, Yanyan Liu, Peijun Wang*, Wenbo Bu*.\r
Oxygen Vacancies-Enhanced CeO2: Gd Nanoparticles for Sensing Tumor Vascular Microenvironment by MRI.\r
ACS Nano, 2018, 12 (12), 12629–12637. （SCI-IF：14.588）\r
40. Han Qiao, Zhaowen Cui, Shengbing Yang, Dingkun Ji, Yugang Wang, Ying Yang, Xiuguo Han, Qiming Fan, An Qin, Tingyu Wang, Xiao-Peng He, Wenbo Bu*, Tingting Tang*.\r
Targeting Osteocyte to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion-Nanoparticles with Responsive Plumbagin Release.\r
ACS Nano, 2017, 11 (7), 7259–7273. （SCI-IF：14.588）\r
41. Dalong Ni, Jiawen Zhang, Jing Wang, Ping Hu, Yingying Jin, Zhongmin Tang, Zhenwei Yao, Wenbo Bu*, Jianlin Shi*.\r
Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent.\r
ACS Nano, 2017, 11 (4), 4256–4264. （SCI-IF：14.588）\r
42. Dalong Ni, Zhiwei Shen, Jiawen Zhang, Chen Zhang, Renhua Wu, Jianan Liu, Meizhi Yi, Jing Wang, Zhenwei Yao, Wenbo Bu*, Jianlin Shi\r
Integrating Anatomic and Functional Dual-Mode Magnetic Resonance Imaging: Design and Applicability of a Bifunctional Contrast Agent.\r
ACS Nano, 2016, 10 (3), 3783–3790. （SCI-IF：14.588）\r
43. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Huaiyong Xing, Fang Han, Qingfeng Xiao, Zhengwei Yao, Feng Chen, Qianjun He, Jianan Liu, Shengjian Zhang, Wenpei Fan, Liangping Zhou, Weijun Peng, Jianlin Shi*.\r
Dual-Targeting Upconversion Nanoprobes across the Blood-Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma.\r
ACS Nano, 2014, 8 (2), 1231–1242. （SCI-IF：14.588）\r
44. Chaochao Wang, Peiran Zhao, Guoliang Yang, Xiaoyan Chen, Yaqin Jiang, Meng Zhang, Xingwu Jiang, Yelin Wu, Yanyan Liu, Weian Zhang,* Wenbo Bu*. \r
Reconstructing the Intracellular pH Microenvironment for Enhancing Photodynamic Therapy.\r
Materials Horizons, 2020, 7, 1180-1185（SCI-IF：12.319）\r
45. Weiwei Su, Chen Chen, Tao Wang, Xiao Li, Yanyan Liu, Han Wang, Danni Li, Shuai Zhao, Changjing Zuo,* Gaofeng Sun,* Wenbo Bu*.\r
Radionuclide Labeled Gold Nanoparticles for Nuclei-Targeting Internal Radio-Immunity Therapy.\r
Materials Horizons, 2020, 7, 1115 - 1125. （SCI-IF：12.319）\r
46. Meng Zhang, Bo Shen, Ruixue Song, Han Wang, Bin Lv, Xianfu Meng, Yang Liu, Yanyan Liu, Xiangpeng Zheng, Weiwei Su, Changjing Zuo*, and Wenbo Bu*.\r
Radiation-Assisted Metal Ion Interference Tumor Therapy by Barium Peroxide-Based nanoparticles.\r
Materials Horizons, 2019, 6, 1034 -1040. （SCI-IF：12.319）\r
47. Peiran Zhao, Zhongmin Tang, Xiaoyan Chen, Ziyu He, Xinhong He, Meng Zhang, Yanyan Liu, Dongdong Ren,* Kuaile Zhao and Wenbo Bu*.\r
Ferrous-Cysteine-Phosphotungstate Nanoagent with Neutral pH Fenton Reaction Activity for Enhanced Cancer Chemodynamic Therapy\r
Materials Horizons, 2019, 6, 369-374. （SCI-IF：12.319）\r
48. Zhongmin Tang, Peiran Zhao, Dalong Ni, Yanyan Liu, Meng Zhang, Han Wang, Hua Zhang, Hongbo Gao, Zhenwei Yao, Wenbo Bu*.\r
Pyroelectric nanoplatform for NIR-ΙΙ triggered photothermal therapy with simultaneous pyroelectric dynamic therapy.\r
Materials Horizons, 2018, 5, 946 – 952. （SCI-IF：12.319）\r
49. Xianfu Meng, Boyu Zhang, Yan Yi, Hui Cheng, Baoming Wang, Yanyan Liu, Teng Gong, Wei Yang, Yefeng Yao, He Wang*, and Wenbo Bu*.\r
Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.\r
Nano Letters. 2019, doi.org/10.1021/acs.nanolett.9b05267.（SCI-IF：11.238）\r
50. Han Wang, Bin Lv, Zhongmin Tang, Meng Zhang, Weiqiang Ge, Yanyan Liu, Xinhong He, Kuaile Zhao, Xiangpeng Zheng, Mingyuan He, and Wenbo Bu*.\r
Scintillator-based Nanohybirds with Sacrificial Electron Prodrug for Enhanced X-ray-induced Photodynamic Therapy.\r
Nano Letters. 2018, 18(9): 5768-5774. （SCI-IF：11.238）\r
51. Wenpei Fan, Bo Shen, Wenbo Bu*, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Kuaile Zhao, Shengjian Zhang, Jianlin Shi*.\r
Design of An Intelligent Sub-50 nm Nuclear-targeting Nanotheranostic System for Imaging Guided Intranuclear Radiosensitization.\r
Chemical Science, 2015, 6, 1747–1753. （SCI-IF：9.346）\r
52. Hua Zhang, Yue Wu, Jing Wang, Zhongmin Tang, Yan Ren, Dalong Ni, Hongbo Gao, Ruixue Song, Teng Jin, Qiao Li, Wenbo Bu*, Zhenwei Yao*.\r
In vivo MR Imaging of Glioma Recruitment of Adoptive T Cells Labeled with NaGdF4-TAT Nanoprobes.\r
Small, 2018, 14, 1702951. （SCI-IF：11.459）\r
53. Jing Wang, Hua Zhang, Dalong Ni, Wenpei Fan, Jianxun Qu, Yanyan Liu, Yingying Jin, Zhaowen Cui, Tianyong Xu, Yue Wu, Wenbo Bu*, Zhenwei Yao*.\r
High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke.\r
Small, 2016, 12 (26): 3591-3600. （SCI-IF：11.459）\r
54. Yang Liu, Shiman Wu, Yanyan Liu*, Hua Zhang, Meng Zhang, Zhongmin Tang, Yan Wang, Teng Gong, Zhenwei Yao, Xiangming Fang*, Wenbo Bu*.\r
Cathodic Protected Mn2+ by NaxWO3 Nanorods for Stable Magnetic Resonance Imaging-Guided Tumor Photothermal Therapy.\r
Biomaterials, 2020, DOI: 10.1016/j.biomaterials.2020.119762.（SCI-IF：10.317）\r
55. Kun Wang, Huilin Zhang, Aijun Shen, Peiran Zhao, Xianfu Meng, Xiaoyan Chen, Yang Liu, Yanyan Liu, Teng Gong, Wanlu Wu, Xiangming Fang*, Peijun Wang, Wenbo Bu*\r
Magnetic Resonance Energy Transfer for in vivo Glutathione Susceptibility Weighted Imaging.\r
Biomaterials, 2020, DOI: 10.1016/j.biomaterials.2019.119703. （SCI-IF：10.317）\r
56. Chaolin Song, Xianfu Meng, Yanyan Liu*, Aijun Sheng, Chulun Shao, Kun Wang, Hui Cheng, Xiangming Fang*, Peijun Wang, Wenbo Bu*\r
Susceptibility-weighted Imaging for Metabolic Pathway Mapping of Low-dosage Nanoparticles in Organisms.\r
Biomaterials, 2019, DOI: 10.1016/j.biomaterials.2019.119631. （SCI-IF：10.317）\r
57. Chen Chen, Weiwei Su, Yanyan Liu, Jiawen Zhang, Changjing Zuo*, Zhenwei Yao, Wenbo Bu*.\r
Artificial Anaerobic Cell Dormancy for Tumor Gaseous Microenvironment Regulation Therapy.\r
Biomaterials, 2019, 200, 48-55. （SCI-IF：10.317）\r
58. Ruixue Song, Meng Zhang, Yanyan Liu, Zhaowen Cui, Hua Zhang, Zhongmin Tang, Xiaoyan Chen, Haihong Wu*, Zhenwei Yao*, Mingyuan He, Wenbo Bu*.\r
A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor.\r
Biomaterials, 2018, 175, 123-133. （SCI-IF：10.317）\r
59. Meng Zhang, Zhaowen Cui, Ruixue Song, Bin Lv, Zhongmin Tang, Xianfu Meng, Xiaoyan Chen, Xiangpeng Zheng, Jiawen Zhang, Zhenwei Yao, Wenbo Bu*\r
SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy.\r
Biomaterials, 2018, 155, 135-144. （SCI-IF：10.317）\r
60. Ping Hu, Tong Wu, Wenpei Fan, Lei Chen, Yanyan Liu, Dalong Ni, Wenbo Bu*, Jianlin Shi*.\r
Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy.\r
Biomaterials, 2017, 141, 86-95. （SCI-IF：10.317）\r
61. Zhaowen Cui, Wenbo Bu, Wenpei Fan, Jiawen Zhang, Dalong Ni, Yanyan Liu, Jianan Liu, Jing Wang, Zhenwei Yao, Jianlin Shi*.\r
Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease.\r
Biomaterials, 2016, 104, 158-167. （SCI-IF：10.317）\r
62. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Chen Zhang, Zhenwei Yao, Huaiyong Xing, Jing Wang, Fei Duan, Yanyan Liu, Wenpei Fan, Xiaoyuan Feng, Jianlin Shi*.\r
PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging.\r
Biomaterials, 2016, 76, 218–225. （SCI-IF：10.317）\r
63. Jing Wang, Dalong Ni, Wenbo Bu*, Qian Zhou, Wenpei Fan, Yue Wu, Yanyan Liu, Lekang Yin, Zhaowen Cui, Xiaoxue Zhang, Hua Zhang, Zhenwei Yao*.\r
BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke.\r
Biomaterials, 2015, 71: 110–118. （SCI-IF：10.317）\r
64. Wenpei Fan, Bo Shen, Wenbo Bu*, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Dalong Ni, Kuaile Zhao, Shengjian Zhang, Jianlin Shi*. \r
Intranuclear Biophotonics by Smart Design of Nuclear-targeting Photo-/radio-sensitizers Co-loaded Upconversion Nanoparticles.\r
Biomaterials, 2015, 69: 89–98. （SCI-IF：10.317）\r
65. Yanyan Liu, Yong Liu, Wenbo Bu*, Qingfeng Xiao, Yong Sun, Kuaile Zhao, Wenpei Fan, Jianan Liu, Jianlin Shi*. \r
Radiation-/Hypoxia-induced Solid Tumor Metastasis and Regrowth Inhibited by Hypoxia-specific Upconversion Nanoradiosensitizer. \r
Biomaterials, 2015, 49: 1–8. （SCI-IF：10.317）\r
66. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Qianjun He, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Dalong Ni, Jianan Liu, Jianlin Shi*.\r
A Smart Upconversion-based Mesoporous Silica Nanotheranostic System for Synergetic Chemo-/Radio-/Photodynamic Therapy and Simultaneous MR/UCL Imaging.\r
Biomaterials, 2014, 35: 8992-9002. （SCI-IF：10.317）\r
67. Qingfeng Xiao, Wenbo Bu*, Qingguo Ren, Shengjian Zhang, Huaiyong Xing, Feng Chen, Ming Li, Xiangpeng Zheng, Yanqing Hua, Liangping Zhou, Weijun Peng, Haiyun Qu, Zheng Wang, Kuaile Zhao, Jianlin Shi*.\r
Radiopaque fluorescence-transparent TaOx decorated upconversion nanophosphors for in vivo CT/MR/UCL trimodal imaging.\r
Biomaterials, 2012, 33: 7530-7539. （SCI-IF：10.317）\r
68. Jianan Liu, Wenbo Bu*, Limin Pan, Shengjian Zhang, Feng Chen, Liangping Zhou, Kuaile Zhao, Weijun Peng, Jianlin Shi*.\r
Simultaneous Nuclear Imaging and Intranuclear Drug Delivery by Nuclear-Targeted Multifunctional Upconversion Nanoprobes.\r
Biomaterials, 2012, 33: 7282-7290. （SCI-IF：10.317）\r
69. Huaiyong Xing, Wenbo Bu*, Qingguo Ren, Xiangpeng Zheng, Ming Li, Shengjian Zhang, Haiyun Qu, Zheng Wang, Yanqing Hua, Kuaile Zhao, Liangping Zhou, Jianlin Shi*.\r
A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal-imaging.\r
Biomaterials, 2012, 33, 5384-5393. （SCI-IF：10.317）\r
70 Huaiyong Xing, Wenbo Bu*, Shengjian Zhang, Xiangpeng Zheng, Ming Li, Feng Chen, Qianjun He, Liangping Zhou, Weijun Peng, Yanqing Hua, Jianlin Shi*. \r
Multifunctional Nanoprobes for Upconversion Fluorescence, MR and CT Trimodal Imaging. \r
Biomaterials, 2012, 33, 1079-1089. （SCI-IF：10.317）