个人简历

本科(化学制药，2000.9)和硕士(药物化学，2003.9)均毕业于沈阳药科大学；博士(药物设计，2006.6)毕业于中科院上海药物研究所；2006.7-至今在华东理工大学药学院任教，历任讲师、副教授、教授。其间，2009.6-2009.8赴美国新墨西哥大学访问研究。2011.3起任药物科学系主任，2015.9起任药学院副院长，2017.5起任药学院党委书记；兼任国家药典委员会委员、中国高等教育学会药学教育研究会理事、上海市青年联合会第十一届委员会委员、第五届中国青年科技工作者协会会员、上海市药学会药物化学专业委员会委员。 \r
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先后入选国家优秀青年科学基金、教育部新世纪优秀人才、上海市曙光学者、上海市科技启明星、上海市徐汇区学科带头人等人才计划。曾荣获药明康德生命化学研究奖、中国药学会-施维雅青年药物化学奖、中国药学会-赛诺菲青年生物药物奖、上海市青年五四奖章、江苏省科学技术三等奖等荣誉称号。作为项目负责人，主持20余项国家和省部课题。迄今已在国内外重要刊物发表论文100余篇，以通讯作者身份发表的代表性论文包括1篇Nat Chem Biol、1篇Nat Commun、10篇J Med Chem；申请发明专利48项(授权16项)，其中1项抗艾滋病的新药专利转让给上海医药集团，2项抗耐药菌的新药专利转让给人福医药集团。

研究领域

"""""1) 老药二次开发\r
2) 抗耐药菌、抗AD、抗疟疾创新药物开发\r
3) 抗衰老机制和创新药物开发"

近期论文

Yanli Lu#, Fei Mao#, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Qing Xu, Jin Zhu, and Jian Li*.\r
Discovery of potent, selective stem cell factor receptor/platelet derived growth factor receptor alpha (c-KIT/PDGFRα) dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors (GISTs). J. Med. Chem. 2017, 60, 5099–5119.\r
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Yifu Liu#, Zuoquan Xie#, Dan Zhao, Jin Zhu, Fei Mao, Shuai Tang, Hui Xu, Cheng Luo, Meiyu Geng, Min Huang*, Jian Li*.\r
Development of the first generation of disulfide-based subtype-selective and potent covalent pyruvate dehydrogenase kinase 1 (PDK1) inhibitors. J. Med. Chem. 2017, 60, 2227−2244.\r
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Xiaokang Li#, Huan Wang#, Zhengyu Lu, Xinyu Zheng, Wei Ni, Jin Zhu, Yan Fu, Fulin Lian, Naixia Zhang, Jian Li*, Haiyan Zhang*, and Fei Mao*.\r
Development of multifunctional pyrimidinylthiourea derivatives as potential anti-Alzheimer agents. J. Med. Chem. 2016, 59, 8326−8344.\r
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Youxin Wang#, Hongxia Di#, Feifei Chen, Yong Xu, Qiang Xiao, Xuehai Wang, Hanwen Wei, Yanli Lu, Lingling Zhang, Jin Zhu, Lefu Lan,* Jian Li*.\r
Discovery of benzocycloalkane derivatives efficiently blocking bacterial virulence for the treatment of methicillin-resistant S. aureus (MRSA) infections by targeting diapophytoene desaturase (CrtN). J. Med. Chem. 2016, 59, 4831–4848.\r
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Youxin Wang#, Feifei Chen#, Hongxia Di, Yong Xu, Qiang Xiao, Xuehai Wang, Hanwen Wei, Yanli Lu, Lingling Zhang, Jin Zhu, Chunquan Sheng, Lefu Lan*, Jian Li*.\r
Discovery of potent benzofuran-derived diapophytoene desaturase (CrtN) inhibitors with enhanced oral bioavailability for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. J. Med. Chem. 2016, 59, 3215–3230. (ACS Editors’ Choice; Highlighted by BioCentury Innovations)\r
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Feifei Chen#, Hongxia Di#, Youxin Wang#, Qiao Cao, Bin Xu, Xue Zhang, Nana Yang, Guijie Liu, Cai-Guang Yang, Yong Xu, Hualiang Jiang, Fulin Lian, Naixia Zhang, Jian Li*, Lefu Lan*.\r
Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence. Nat. Chem. Biol. 2016, 12, 174–179. (Highlighted by Nature Reviews Drug Discovery,BioWorld Today, and BioCentury Innovations)\r
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Huang Huang#, Ying Yu#, Zhenting Gao, Yong Zhang, Chenjing Li, Xing Xu, Hui Jin, Wenzhong Yan, Ruoqun Ma, Jin Zhu, Xu Shen, Hualiang Jiang, Lili Chen*, Jian Li*.\r
Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists. J. Med. Chem. 2012, 55, 7037−7053.\r
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Jing Deng#, Ning Li#, Hongchuan Liu#, Zhili Zuo#, Oi Wah Liew, Weijun Xu, Gang Chen, Xiankun Tong, Wei Tang*, Jin Zhu, Jianping Zuo, Hualiang Jiang, Cai-Guang Yang*, Jian Li*, Weiliang Zhu*.\r
Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping. J. Med. Chem. 2012, 55, 6278–6293.\r
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Jing Deng#, Enguang Feng#, Sheng Ma#, Yan Zhang, Xiaofeng Liu, Honglin Li*, Huang Huang, Jin Zhu, Weiliang Zhu, Xu Shen, Liyan Miao*, Hong Liu, Hualiang Jiang, Jian Li*.\r
Design and synthesis of small molecule RhoA inhibitors: A new promising therapy for cardiovascular diseases? J. Med. Chem. 2011, 54, 4508–4522. (本论文被自然旗下SciBX (4(25), doi:10.1038/scibx.2011.710)列为心血管药物的重要研究成果之一进行了亮点报道)\r
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Shilei Zhang#, Hexin Xie#, Jin Zhu, Hao Li, Xinshuai Zhang, Jian Li*, Wei Wang*.\r
Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions. Nat. Commun. 2011, 2, 211 (本论文分别被美国Chemical & Engineering News作为专家评述和德国化学评论期刊SYNFACTS作为有机合成亮点评述)\r
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Shuaishuai Ni#, Yaxia Yuan#, Jin Huang#, Xiaona Mao, Maosheng Lv, Jin Zhu, Xu Shen, Jianfeng Pei*, Luhua Lai, Hualiang Jiang, Jian Li*.\r
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J. Med. Chem.2009, 52, 5295–5298.\r
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Honglin Li#, Jin Huang#, Lili Chen, Xiaofeng Liu, Tong Chen, Jin Zhu, Weiqiang Lu, Xu Shen, Jian Li*, Rolf Hilgenfeld*, Hualiang Jiang*.\r
Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening. J. Med. Chem.2009, 52, 4936–4940.