个人简历

工学博士，华东理工大学生物工程学院教授，博士生导师， 国家生化工程技术研究中心（上海）副主任。1963年8月出生于上海，1985获华东化工学院学士学位, 88年获硕士学位。96年于华东理工大学获生物化工工学博士学位。88年毕业后留校从事国家七.五攻关项目，溶氧电极和谷氨酸电极的研制以及葡萄糖氧化酶发酵、提纯工作等。90年10月在大阪大学发酵工学科从事基因工程研究一年；91年应邀到英国Bath大学进行膜发酵研究一年。92年12月回国后,获国家教委资助的留学回国人员基金, 从事螺旋霉素膜过滤发酵研究, 国家自然科学基金项目葡萄糖氧化酶膜透析发酵以及葡萄糖氧化酶菌种选育工作, \

研究领域

微生物代谢调控机制及代谢工程研究
工业发酵过程优化与放大

近期论文

1. Guo Qian, Chu Ju*, Zhuang Yingping, Gao Yang. Controlling the feed rate of propanol to optimize erythromycin fermentation by on-line capacitance and oxygen uptake rate measurement [J]. Bioprocess and Biosystems Engineering, 2016, 39(2): 255-265.
2. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. Enhanced l-lactic acid production in Lactobacillus paracasei by exogenous proline addition based on comparative metabolite profiling analysis [J]. Applied Microbiology and Biotechnology, 2016, 100(5): 2301-2310.
3. Lu Fei, Wang Zejian, Zhao Wei, Chu Ju*, Zhuang Yingping. A simple novel approach for real-time monitoring of sodium gluconate production by on-line physiological parameters in batch fermentation by Aspergillus niger [J]. Bioresource Technology, 2016, 202: 133-141.
4. Tian Xiwei, Zhang Ning, Yang Yi, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. The effect of redox environment on l-lactic acid production by Lactobacillus paracasei—A proof by genetically encoded in vivo NADH biosensor [J]. Process Biochemistry, 2015, 50(12): 2029-2034.
5. Lu Hongzhong, Liu Xiaoyun, Huang Mingzhi*, Xia Jianye, Chu Ju*, Zhuang Yingping, Zhang Siliang, Noorman Henk. Integrated isotope-assisted metabolomics and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger [J]. Microbial Cell Factories, 2015, 14(1): 147-160.
6. Lu Fei, Ping Kangkang, Wen Lin, Zhao Wei, Wang Zejian*, Chu Ju*, Zhuang Yingping. Enhancing gluconic acid production by controlling the morphology of Aspergillus niger in submerged fermentation [J]. Process Biochemistry, 2015, 50(9): 1342-1348.
7. Tang Wenjun, Pan Ao, Lu Hongzhong, Xia Jianye*, Zhuang Yingping, Zhang Siliang, Chu Ju*, Noorman Henk. Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer [J]. Biochemical Engineering Journal, 2015, 99: 167-176.
8. Lu Hongzhong, Li Chao, Tang Wenjun, Wang Zejian, Xia Jianye*, Zhang Siliang, Zhuang Yingping, Chu Ju*, Noorman Henk. Dependence of fungal characteristics on seed morphology and shear stress in bioreactors [J]. Bioprocess and Biosystems Engineering, 2015, 38(5): 917-928.
9. Shi Fei, Tan Jun, Chu Ju*, Wang Yonghong, Zhuang Yingping, Zhang Siliang. A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger [J]. Journal of Microbiological Methods, 2015, 109: 134-139.
10. Chen Yong, Wang Zejian, Chu Ju*, Xi Beili, Zhuang Yingping. The glucose RQ-feedback control leading to improved erythromycin production by a recombinant strain Saccharopolyspora erythraea ZL1004 and its scale-up to 372-m3 fermenter [J]. Bioprocess and Biosystems Engineering, 2015, 38(1): 105-112.
11. Wang Guan, Tang Wenjun, Xia Jianye, Chu Ju*, Noorman Henk, van Gulik Walter M.. Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses [J]. Engineering in Life Sciences, 2015, 15(1): 20-29.
12. Tan Jun, Chu Ju*, Wang Yonghong, Zhuang Yingping, Zhang Siliang. High-throughput system for screening of Monascus purpureus high-yield strain in pigment production [J]. Bioresources and Bioprocessing, 2014, 1(1): 1-7.
13. Zhang Qiang, Chen Yong, Hong Ming, Gao Yang, Chu Ju*, Zhuang Yingping, Zhang Siliang. The dynamic regulation of nitrogen and phosphorus in the early phase of fermentation improves the erythromycin production by recombinant Saccharopolyspora erythraea strain [J]. Bioresources and Bioprocessing, 2014, 1(1): 1-6.
14. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on l-lactic acid production efficiency by Lactobacillus paracasei [J]. Process Biochemistry, 2014, 49(12): 2049-2054.
15. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. l-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination [J]. Bioprocess and Biosystems Engineering, 2014, 37(9): 1917-1923.
16. Wang Guan, Chu Ju*, Noorman Henk, Xia Jianye, Tang Wenjun, Zhuang Yingping, Zhang Siliang. Prelude to rational scale-up of penicillin production: a scale-down study [J]. Applied Microbiology and Biotechnology, 2014, 98(6): 2359-2369.
17. Zhu Pei, Chen Daijie, Liu Wenbin, Zhang Jianbin, Shao Lei, Li Ji-an, Chu Ju*. Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion [J]. Bioresource Technology, 2014, 153: 95-100.
18. Chen Yong, Huang Mingzhi, Wang Zejian, Chu Ju*, Zhuang Yingping, Zhang Siliang. Controlling the feed rate of glucose and propanol for the enhancement of erythromycin production and exploration of propanol metabolism fate by quantitative metabolic flux analysis [J]. Bioprocess and Biosystems Engineering, 2013, 36(10): 1445-1453.
19. Tan Jun, Chu Ju*, Hao Yuyou, Wang Yonghong, Yao Sichao, Zhuang Yingping, Zhang Siliang. A high-throughput screening strategy for accurate quantification of erythromycin [J]. Journal of the Taiwan Institute of Chemical Engineers, 2013, 44(4): 538-544.
20. Chen Yong, Wang Zejian, Chu Ju*, Zhuang Yingping, Zhang Siliang, Yu Xiaoguang. Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate [J]. Bioresource Technology, 2013, 134: 173-179.