个人简历

汪洋，副教授，博士，硕士生导师，湖北工业大学生物工程与食品学院生物工程系副主任，湖北省“楚天学者计划”楚天学子，“3551光谷人才计划”获得者，湖北省“双创战略团队”核心成员。研究方向为溶瘤病毒（OH2）抗肿瘤机制研究；I类抗肿瘤新药OH2的临床前研究和临床试验。担任中文核心期刊《中国预防兽医学报》、SCI期刊VeterinaryMicrobiology审稿人。主持国家自然科学基金青年基金1项，企业横向课题3项。参与Bill&MelindaGatesFoundation基金、国家重大新药创制计划、国家自然科学基金面上项目等项目。获黑龙江省科技进步三等奖一项，在HumanGenetherapy,BMCGenomics，DevelopmentalandComparativeImmunology,ScientificReports等SCI杂志上第一作者发表论文10篇。

工作、学习经历：

2018.08-至今湖北工业大学副教授

2015.08-2018.07湖北工业大学讲师

2014.10-2015.03非盟-泛非洲动物疫苗中心（AU-PANVAC）访问交流

2012.07-2015.07中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室助理研究员

2007.09-2012.06华中农业大学动物医学院农业微生物学国家重点实验室（硕博连读）博士

2003.09-2007.08长江大学生命科学学院学士

牛传染性胸膜肺炎的流行病学监测与国际认证2014年黑龙江省科技进步三等奖（排名第三）

1.牛支原体脂质相关膜蛋白（LAMPs）诱导胎牛肺细胞IL-1β释放的分子机制研究,国家自然科学基金青年基金,31502090,2016年1月至2018年12月,主持，20万

2.溶瘤II型单纯疱疹病毒的肺癌治疗性疫苗的研发，横向课题，2016229，2016年1月至2017年12月，主持，30万

3.择瘤繁殖并表达绿色荧光蛋白的重组II型单纯疱疹病毒检测循环肿瘤细胞试剂盒的开发，横向课题，2016278，2016年1月至2017年12月，主持，20万

4.病毒激活免疫细胞（VAK）抗肿瘤免疫治疗技术的研发，横向课题，2017232，2017年1月至2018年12月，主持，150万

研究领域

溶瘤病毒抗肿瘤分子机制研究；I类抗肿瘤新药的临床前研究与临床试验

近期论文

1)Preclinicalsafetyevaluationofoncolyticherpessimplexvirustype2.YangWang,XiaobingZhou,ZhenWu,HanHu,JingJin,YanpingHu,YutingDong,JianwenZou,ZeyongMao,XiaotaiShi,YanHuo,JianjunLyu,ZhizhengFang,WenZhang,YujieZhu,BoLi,BinleiLiu.HumanGenetherapy,2018,doi:DOI:10.1089/hum.2018.170.

2)Stabilityandanti-tumoreffectofoncolyticherpessimplexvirustype2.YangWang,JingJin,ZhenWu,ShengHu,HanHu,ZhifengNing,YanfeiLi,YutingDong,JianwenZou,ZeyongMao,XiaotaiShi,HuajunZheng,ShuangDong,FuxingLiu,ZhizhengFang,JiliangWuandBinleiLiu.Oncotarget,2018,9:24672-24683.

3)TranscriptionanalysisonresponseofporcinealveolarmacrophagestoHaemophilusparasuis.YangWang,ChongLiu,YingFang,XiaoliLiu,WentaoLi,ShuqingLiu,YingyuLiu,YuxiLiu,CatherineCharreyre,JeanChristopheAudonnet,PinChen,QigaiHe.BMCGenomics,2012,13:68.

4)Mycoplasmabovis-derivedlipid-associatedmembraneproteinsactivateIL-1βproductionthroughtheNF-κBpathwayviaToll-likereceptor2andMyD88.YangWang,SuliLiu,YuanLi,QiWang,JiariShao,YingChen,JiuqingXin,DevelopmentalandComparativeImmunology2016,55:111-118

5)PorcineCoronin1AcontributestoinhibitNF-κBactivationduringHaemophilusparasuisinfection.ChongLiu#,YangWang#,HenglingZhang,ShuangCheng,XiaoliLiu,XiaofeiWang,CatherineCharreyre,JeanChristopheAudonnet,PinChen,RuiZhou,HuanchunChen,QigaiHe*.PlosOne2014,8:e103904

6)Mmm-derivedlipid-associatedmembraneproteinsactivateIL-1bproductionthroughtheNF-κBpathwayviaTLR2,MyD88,andIRAK4.YangWang,QiWang,YuanLi,YingChen,JiariShao,NickNwankpa,ChunyanLi,JiuqingXin.ScientificReports,2017,7:4349.

7)ChangesinpathogenicityandimmunogenicityofMycoplasmamycoidessubsp.mycoidesstrainsrevealedbycomparative.YuanLi#,YangWang#,WangRui,YongqiangZhu,SuliLiu,QiWang,JiariShao,YingChen,LipingGao,ChangpingZhou,HengguiLiu1,XiumeiWang,HuajunZhengandJiuqingXin.ScientificReports,2016,6:19081.

8)P19contributetoMycoplasmamycoidessubsp.mycoidesadhesiontoEBLcells.YumeiZhou#,YangWang#,YuanLi,NwankpaNick,XiaohuiZou1，FanBai,JindiWu,JiuqingXin.MicrobialPathogenesis.2016,93:13-21

9)Loop-mediatedisothermalamplificationtargetingtheapxIVAgenefordetectionofActinobacilluspleuropneumoniae.YangWang,PinChen,HaibingGuo,YangChen,HuiLiu,QigaiHe.FEMSMicrobiologyLetters,2009,300:83-89

10)Developmentandevaluationofloop-mediatedisothermalamplificationforrapiddetectionofHaemophilusparasuis.YangWang,YingFang,YingyuLiu,PinChen,WentaoLi,ShuqingLiu,HaoyongZou,QigaiHe.FEMSMicrobiologyLetters,2010,313:54-60.

11)MolecularcloningandcharacterizationofanewvariablesurfaceproteininaMycoplasmabovisHubei-1Strain.XiaohuiZou,YuanLi,YangWang,YumeiZhou,YangLiu,JiuqingXin*.PlosOne,2013,8：69644

12)Proteomicanalysisofporcinealveolarmacrophagesinfectedwithporcinecircovirustype2.ShuangCheng,MinZhang,WentaoLi,YangWang,YingyuLiu,QigaiHe.JournalofProteomics,2012,75:3258-3269

13)Transcriptionanalysisoftheporcinealveolarmacrophageresponsetoporcinecirovirustype2,WentaoLi,ShuqingLiu,YangWang,FengDeng,WeidongYan,KunYang,HuanchunChen,QigaiHe,CatherineCharreyre,Jean-ChristopheAudoneet.BMCGenomics,201314:353

14)TranscriptionalProfilingofHaemophilusparasuisSH0165ResponsetoTilmicosin.YingyuLiu,PinChen,YangWang,WentaoLi,ShuangCheng,ChunmeiWang,AndingZhang,andQigaiHe.MicrobialDrugResistance,2012,18(6):604-15

15)Porcinereproductiveandrespiratorysyndromevirusnonstructuralprotein2contributestoNF-κBactivation.YingFang,LiurongFang,YangWang,YingyingLei,RuiLuo,DangWang,HuanchunChenandShaoboXiao.VirologyJournal,2012,9:83.

16)BroadactivityagainstporcinebacterialpathogensdisplayedbytwoinsectantimicrobialpeptidesmoricinandcecropinB.HanHu,ChunmeiWang,XiaozhenGuo,WentaoLi,YangWang,QigaiHe.MoleculesandCells,2013,35:106-114.

17)Efficacyofsingledoseofaninactivatedporcinecircovirustype2(PCV2)whole-virusvaccinewithoiladjuvantinpiglets.KunYang,WentaoLi,HuihuiNiu,WeidongYan,XiaoliLiu,YangWang,ShuangCheng,XugangkuandQigaiHe.ActaVeterinariaScandinavica,2012,54,67.

18)Treatmentofcoloncancerwithoncolyticherpessimplexvirusinpreclinicalmodels.HYang,TPeng,JLi,YangW,WZhang,PZhang,SPeng,TDu,YLi,QYanandBLiu.GeneTherapy,2016,23:450-459