个人简历

学习和工作简历：
1983年9月-1987年7月：武汉大学化学系四年制本科生；
1987年9月-1990年7月：武汉大学化学系三年制硕士生；
1990年8月-1993年12月：：北京大学化学与分子工程学院四年制博士生；
1993年12月-1995年11月：中科院研究生院化学部博士后；
1995年12月-现在：湖北大学生命科学学院教授、博士生导师。

承担科研项目情况：
1.杜仲叶、山麦冬标准提取物研究。01年武汉市科委重大科技攻关项目（50万，No.20016001008），主持人
2.指纹图谱应用示范研究。科技部十五攻关项目（中医药现代化研究与产业化开发）（程翼宇主持，No.2001BA701A01），联合申报单位负责人（分配经费10万）
3.中药标准提取物及其指纹图谱研究。湖北省青年杰出人才科学基金（10万，No.2002AC004），主持人
4.慢性肝炎中医“证”分型的分子基础研究。国家重大基础研究前期专项（30万，No.2002ccc00300），主持人
5.用于中药临床前安全性评价的毒理芯片开发研究。湖北省科技厅（6万，No.2004AA303B05）和武汉市科技局重点攻关项目（10万，No.20036003042），主持人
6.确有疗效复方中药痹祺胶囊的药代动力学研究。07年国家自然科学基金重点项目（刘昌孝院士主持，No.30630075），联合申报单位主持人（分配经费35万）
7.复方脉君安片的药动学与分子药理学研究。湖北省高等学校优秀中青年团队计划项目（32万，No.T200807），主持人
8.浓缩型脉君安片临床前研究。湖北省发改委生物产业专项项目（No.鄂发改高技[2008]1365号-1，40万），主持人
9.抗乙肝病毒药物筛选关键技术。湖北省发改委生物产业专项项目（湖北省生物产业专项，No.鄂发改投资[2009]1734号，50万），主持人
10.与乙型病毒性肝炎病毒生活周期相关的细胞因子或靶分子。艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项课题（吴建国主持，No.2008ZX10204），联合申报单位负责人（分配经费20万）
获得的授权发明专利
1．陈勇，李紫，蔡敏。山麦冬多糖提取工艺。发明专利，专利号ZL02147758.2
2.韩凤梅，杜鹏，郭小龙，陈勇。一种以枸杞酒渣为原料制备高免疫调节活性枸杞多糖的酶解工艺。发明专利，专利授权号ZL200710052400.7
3.陈勇，韩凤梅，张继业，张仙，王恒松。一种服用剂量小的浓缩型脉君安片或胶囊配方及其制备方法。发明专利，专利授权号ZL200810048199.X

近期论文

1.HuaixiaChen,YongChen,HongWang,PengDu,FengmeiHan,HuashanZhang.AnalysisofscopolamineanditseighteenmetabolitesinraturinebyLCtandemmassspectrometry.Talanta,2005,67:984-991
2.HuaixiaChen,HongWang,YongChen,HuangshanZhang.Liquidchromatography-tandemmassspectrometryanalysisofanisodamineanditsphaseIandIImetabolitesinraturine.J.chromatographyB,2005,824:21-29
3.YongChen,HuaixiaChen,PengDu,FengmeiHan,HuashanZhang,TheAnalysisofAnisodineandtheIdentificationofTwentyofItsMetabolitesinRatUrinebyLiquidChromatography-TandemMassSpectrometry.Chromatographia,2005，62：563-569
4.HuaixiaChen,YongChen,PengDu,FengmeiHan,HongWang,HuashanZhang.Sensitiveandspecificliquidchromatographic-tandemmassspectrometricassayforatropineanditselevenmetabolitesinraturine.J.PharmaceuticalandBiomedicalAnalysis，2006，40：142
5.HANFeng-Mei,CHENGMing,XIAQi-Song,CHENYong.Geneexpressionprofileinimmunologicallyinjuredlivercellofmice.ScienceinChinaSeriesC-LifeSciences，2006，49(5):454-459
6.M.M.Zhu,H.X.Chen,F.M.Han,Y.Chen.AnalysisofArecolineandIdentificationofItsMetabolitesinRatUrinebyLiquidChromatography-TandemMassSpectrometry.Chromatographia，2006，64(11/12):705-708
7.H.X.Chen,Y.Chen,P.Du,F.M.Han.LC-MSforidentificationandelucidationofthestructureofin-vivoandin-vitrometabolitesofatropine.Chromatographia,2007,65:413-418
8.MingmingZhu,FengmeiHan,HuaixiaChen,ZhihongPengYongChen.Identificationofpalmatineanditsmetabolitesinraturinebyliquidchromatography-tandemmassspectrometry.Rapidcommunicationsinmassspectrometry,2007,21（13）:2019-2022
9.YongChen,Xiao-mingZhang,Feng-meiHan,PengDu,Qi-songXia.GeneexpressionprofilinganalysesofinjuredmiceliversbyLeigongteng(TripterygiumWilfordiiHook.f.).WorldJournalofgastroenterology,2007,13（26）：3619-3624
10.F.M.Han,Z.H.Peng,W.Song,H.M.Zhang,M.M.Zhu,Y.Chen.Identificationofdauricineanditsmetabolitesinraturinebyliquidchromatography-tandemmassspectrometry.J.ofChromatographyB,2007,854(1/2):1-7
11.HuaixiaChen,YongChen,PengDu,FengmeiHan.Structuralelucidationofin–vivoandin-vitrometabolitesofanisodinebyliquidchromatography-tandemmassspectrometry.J.ofPharmaceuticalandBiomedicalAnalysis.2007,44(3):773-778
12.Y.Chen,Z.H.Peng,M.M.Zhu,F.M.Han.Chromatographictandemmassspectrometricdetectionofpapaverineanditsmajormetabolitesinraturine.InternationalJ.ofMassSpectrometry,2007,266:114-121
13.B.Y.Ge,H.X.Chen,F.M.Han,Y.Chen.IdentificationofAmygdalinanditsmajormetabolitesinRatUrinebyLC-MS/MS.J.ofChromatographyB,2007,857:281-286
14.WeiSong,ZhihongPeng,BaoyingGe,FengmeiHan,YongChen.Identificationofmetabolitesoflobelineintheraturinebyliquidchromatography-tandemmassspectrometry.InternationalJ.ofMassSpectrometry,2007,269:131-137
15.Y.Chen*;Z.H.Peng;W.Song;M.M.Zhu;F.M.Han.ChromatographicTandemMassSpectrometricDetectionofPhysostigmineanditsMajorMetabolitesinRatUrine.AnalyticalLetters,2007(40):3256-3266
16.Y.Chen,W.Song,Z.H.Peng,B.Y.Ge,F.M.Han.Identificationofmetabolitesoftectoridininvivoandinvitrobyliquidchromatography-tandemmassspectrometry.J.ofPharmacyandPharmacology,2008,60:1-8
17.Yizhang,WenhuaWu,FengmeiHan,YongChen.LC/MS/MSforidentificationofinvivoandinvitrometabolitesofjatrorrhizine.BiomedicalChromatography,2008,22(12):1360-1367(SCI)
18.QianC.Yang,WenH.Wu,FengM.Han,YongChen.Identificationofinvivoandinvitrometabolitesofpalmatinebyliquidchromatography-tandemmassspectrometry.J.ofPharmacyandPharmacology,2009,61:647-652
19.XingxingKong,HengFan,XiaojunLiu,RuiWang,JichaoLiang,NishithGupta,YongChen,FudeFang,YongshengChang.PeroxisomeProliferator-ActivatedReceptorγCoactivator-1αEnhancesAntiproliferativeActivityof5′-Deoxy-5-FluorouridineinCancerCellsthroughInductionofUridinePhosphorylase.MolecularPharmacology,2009,76:854-860
20.PengZH,SongW,HanFM,ChenY.Invivoandinvitrostudyofpapaverineanditsmajormetabolites.ActaPhamaceuticaSinica,2009(44):95-100
21.Feng-meiHan,Qian-chengYang,PengDu,Wen-huaWu,YongChen.Themetabolismofstrychnineinratlivermicrosomesandmetabolicinteractionwithglycyrrheticacidinvitro.AsianJournalofPharmacodynamicsandPharmacokinetics,2009,9(4):301-312
22.F.M.Han,M.M.Zhu,H.X.Chen,Y.Chen.Identificationofsophoridineanditsmetabolitesinraturinebyliquidchromatography-tandemmassspectrometry.AnalyticalLetters,2010,43(1):45-54
23.Liu-LuanZhu,YangLiu,An-FangCui,DiShao,Ji-ChaoLiang,Xiao-JunLiu,YongChen,NishithGupta,Fu-DeFang,Yong-ShengChang.PGC-1αcoactivatesestrogen-relatedreceptor-αtoinducetheexpressionofglucokinase.AmJPhysiolEndocrinolMetab.2010,298:1210–E1218.
24.XingxingKong,RuiWang,YuanXue,XiaojunLiu,HuabingZhang,YongChen,FudeFang,YongshengChang.Sirtuin3,aNewTargetofPGC-1a,PlaysanImportantRoleintheSuppressionofROSandMitochondrialBiogenesis.PLoSOne.2010,5:1-13
25.YangQC,HanFM,XiongYQ,XingPP,ChenY.ThemetabolismofglycyrrheticacidinratlivermicrosomesandinvitrometabolicinteractionwithsixCYP450probesubstrates.AsianJofPharmacodynamicsandPharmacokinetics,2010,10(4):310-319
26.LiLiu,JuanXiao,ZhihongPeng,YongChen.InvitrometabolismofglycyrrheticacidbyhumancytochromeP450.ActaPhamaceuticaSinica,2011，46（1）：81-87
27.XINGPan-pan,WUWen-hua,DUPeng,HANFeng-mei,CHENYong.EffectsofbrucinecombinedwithglycyrrhetinicacidorliquiritinonrathepaticcytochromeP450activitiesinvivo[J].ActaPharmaceuticaSinica2011,46(5):573-580.
28.QianGao,Jun-junWang,Feng-meiHan,YongChen.EffectofstrychninehydrochlorideonlivercytochromeP450mRNAexpressionandmonooxygenaseactivitiesinrat[J].ActaPharmaceuticaSinicaB,2011;1(2):121–128.
29.AijunQiao,JichaoLiang,YaojunKe,ChenghongLi,YingCui,LianShen,HuabingZhang,AnfangCui,XiaojunLiu,ChangzhengLiu,YongChen,YiZhu,YoufeiGuan,FudeFang,andYongshengChang.MousePatatin-LikePhospholipaseDomain-Containing3InfluencesSystemicLipidandGlucoseHomeostasis[J].Hepatology,2011,54(2):509-521.
30.Zhi-hongPeng,Jun-junWang,PengDu,YongChen.Identificationofinvivoandinvitrometabolitesoftriptolidebyliquidchromatography–tandemmassspectrometry[J].JournalofPharmaceuticalandBiomedicalAnalysis,2012,70:624–630.
31.JichaoLiang,FengmeiHan,YongChen.Anelectrochemicalmethodforhighsensitivedetectionofnicotineanditsinteractionwithbovineserumalbumin[J].ElectrochemistryCommunications,2012,24:93–96.
32.JichaoLiang,ChangzhengLiu,AijunQiao,YingCui2,,HuabingZhang,AnfangCui,ShutianZhang,YanliYang,,XinhuaXiao,YongChen,FudeFang,YongshengChang.MicroRNA-29a-cdecreasefastingbloodglucoselevelsbynegativelyregulatinghepaticgluconeogenesis[J].JournalofHepatology,2013,58:535–542.
33.Xiao-minChen,MinWei,Hai-mouZhang,Cheng-haoLuo,Yi-kunChen,YongChen.EffectofvanillinandethylvanillinonCytochromeP450activityinvitroandinvivo[J].FoodChemToxicol,2012,50(6):1897-1901
34.YiMingjing,PengWei,ChenXiaomin,WangJunjun,ChenYong.EffectofhypaconitinecombinedwithliquiritinontheexpressionofCalmodulinandConnexin43inratcardiacmuscleinvivoo[J].JournalofPharmacyandPharmacology.2012,64:1654–1658.
35.LIULi,XIAOJuan,PENGZhi-hong,WUWen-hua,DUPeng,CHENYong.InvitroMetabolismofStrychninebyHumanCytochromeP450andItsInteractionwithGlycyrrheticAcido[J].ChineseHerbalMedicines,2012,4(2):118-125.