个人简历

成果获奖情况
1.2型糖尿病及其并发症机制探讨及干预措施研究,2016年度河北省科技进步三等奖，第一完成人。
2.过氧亚硝基阴离子在哮喘气道高反应性形成中的作用及机制研究，2009年度河北省科技进步三等奖，第一完成人。
完成科研项目
1.国家自然科学基金面上项目，81071846、FilaminA与Caveolin-1相互作用对EGFR活化的影响、2011/01-2013/12、33万元、主持人。
2.教育部回国留学人员科研启动基金项目，2010年批准、FilaminA对表皮生长因子受体活化的调控作用、2010/01-2012/12、5万元、主持人。
3.河北省科技支撑计划项目，10276105D-66、PDTC对高糖\

近期论文

1.TongyouSun,TienianZhu*,XiujunLiang,ShifangYang,RuijingZhao.Effectsofrecombinantcircularlypermutedtumornecrosisfactor(TNF)-relatedapoptosis-inducingligand(TRAIL)(recombinantmutanthumanTRAIL)incombinationwith5-FluorouracilinhumancolorectalcancercelllinesHCT116andSW480.MedSciMonit.2018,24(4):2550-2561.（通讯作者）
2.YunaZhang,TienianZhu*,JingpuLiu,JiankunLiu,DongmeiGao,TongyiSu,RuijingZhao.FLNanegativelyregulatedproliferationandmetastasisinlungadenocarcinomaA549cellsviasuppressionofEGFR.ActaBiochimBiophysSin.2018,50(2):164-170.（通讯作者）.
3.JuanliYang,TienianZhu*,RuijingZhao,DongmeiGao,YujieCui,KunWang,YanliGuo.Caveolin-1InhibitsProliferation,Migration,andInvasionofHumanColorectalCancerCellsbySuppressingPhosphorylationofEpidermalGrowthFactorReceptor.MedSciMonit.2018,24(1):332-341.（通讯作者）.
4.YujieCui,TienianZhu,XuejingSong,JiankunLiu,ShuangLiu,RuijingZhao.Downregulationofcaveolin-1increasedEGFR-TKIssensitivityinlungadenocarcinomacelllinewithEGFRmutation.BiochemBiophysResCommun.2018,495(1):733-739.（通讯作者）.
5.YanliGuo,TienianZhu*,WeiGuo,ZhimingDong,ZhenZhou,YujieCui,RuijingZhao.AberrantCpGislandshoreregionmethylationofCAV1isassociatedwithtumorprogressionandpoorprognosisingastriccardiaadenocarcinoma.ArchMedRes,2016,47(6):460-470.（通讯作者）.
6.LuanTY,ZhuTN*,CuiYJ,ZhangG,SongXJ,GaoDM,ZhangYM,ZhaoQL,LiuS,SuTY,ZhaoRJ.Expressionofcaveolin-1iscorrelatedwithlungadenocarcinomaproliferation,migration,andinvasion.MedOncol,2015,32(7):207.（通讯作者）
7.GuihongLiu,TienianZhu*,YujieCui,JingpuLiu,JiankunLiu,QinglanZhao,KaiZhang,RuijingZhao.CorrelationbetweenIGF2BP2genepolymorphismandtheriskofbreastcancerinChineseHanwomen.Biomedicine&Pharmacotherapy,2015,69：297-300.（通讯作者）
8.YanHuang,XiuhuaGuo,HongyangWang,TienianZhu*.Predictivevalueofthymidylatesynthasefortheprognosisandsurvivaloflungadenocarcinomapatients.OncologyLetters,2015,9:252-256.(通讯作者)
9.KaiZhang,TienianZhu*,DongmeiGao,YimeiZhang,QinglanZhao,ShuangLiu,TongySu,MichelBernier,RuijingZhao.FilaminAexpressioncorrelateswithproliferationandinvasivepropertiesofhumanmetastaticmelanomatumors:implicationsforsurvivalinpatients.JCancerResClinOncol,2014,140:1913–1926.（通讯作者）
10.HaiyanDing,TienianZhu*,XiaomeiYin,JiankunLiu,LizhongZhang,MichelBernier,RuijingZhao.Pyrrolidinedithiocarbamateprotectspancreaticb-cellsfromoxidativedamagethroughregulationofFoxO1activityintype2diabetesrats.ActaBiochimBiophysSin,2014,46(7):582-589.（通讯作者）
11.GuoW,ZhuT*,DongZ,CuiL,ZhangM,KuangG.DecreasedexpressionandaberrantmethylationofGadd45Gisassociatedwithtumorprogressionandpoorprognosisinesophagealsquamouscellcarcinoma.ClinExpMetastasis.2013,30(8):977-992.（通讯作者）
12.GuoW,DongZ,LinX,ZhangM,KuangG,ZhuT*.DecreasedexpressionandaberrantmethylationofRafkinaseinhibitoryproteingeneinesophagealsquamouscellcarcinoma.CancerInvest,2012,30(10):703-711.（通讯作者）
13.TienianZhu*,RuijingZhao,LizhongZhang,MichelBernier,JiankunLiu.PyrrolidineDithiocarbamateEnhancesHepaticGlycogenSynthesisandReducesFoxO1-mediatedGeneTranscriptionintheFat-fed,Streptozotocin-treatedRats.AmJPhysiolEndocrinolMetab.2012,302(4)：E409-E416.
14.JenniferL.Fiori,Tie-NianZhu*,MichaelP.O’Connell,KeithS.Hoek,FredE.Indig,BrittanyP.Frank,ChristaMorris,SutapaKole,JoanneHasskamp,GeorgeElias,AshaniT.Weeraratna,andMichelBernier.FilaminAmodulateskinaseactivationandintracellulartraffickingofepidermalgrowthfactorreceptorsinhumanmelanomacells.Endocrinology,2009,150(6):2551–2560.(并列第一作者)
15.Tie-NianZhu,Hua-JunHe,SutapaKole,TheresaD’Souza,RachanaAgarwal,PatriceJ.MorinandMichelBernier.FilaminA-MediatedDownregulationoftheExchangeFactorRas-GRF1CorrelateswithDecreasedMatrixMetalloproteinase-9ExpressioninHumanMelanomaCells.JBiolChem,2007,282（20）：14816-14826.
16.Hua-JunHe,Tie-NianZhu*,YiXie,JinshuiFan,SutapaKole,SatyaSaxena,andMichelBernier.PyrrolidineDithiocarbamateInhibitsInterleukin-6SignalingthroughImpairedSTAT3ActivationandAssociationwithTranscriptionalCoactivatorsinHepatocytes.JBiolChem,2006,281(42):31369–31379.(并列第一作者)
17.Hua-JunHe,RickPires,Tie-NianZhu,AnhongZhou,AdolfasK.Gaigalas,Sige,Zou,LiliWang.AFluorescenceResonanceEnergyTransferBasedMethodforDetectionofDNABindingActivitiesofNuclearFactorB.Biotechniques,2007,43(1):93-98.
18.MichelBernier,Yong-KookKwon,SanjayK.Pandey,Tie-NianZhu,Rui-JingZhao,AlexandreMaciuk,Hua-JunHe,RafaelDeCabo,andSutapaKole.BindingofmanumycinAnegativelyregulatesIBKinaseActivity.JBiolChem,2006,281(5):2551-2561.
19.Jun-FengLiu,Shao-WeiZhang,GlynG.Jamieson,Gui-JunZhu,Tie-ChengWu,Tie-NianZhu,Bao-EnShan,PaulA.Drew.TheeffectsofaCOX-2inhibitormeloxicamonsquamouscellcarcinomaoftheesophagusinvivo.IntJCancer,2008,122(7):1639-44.
20.Jun-FengLiu,Gui-JunZhu,GlynG.Jamieson,Tie-ChengWu,Tie-NianZhu,Bao-EnShan,PaulA.Drew.NS-398inducesapoptosisinhumanesophagealcancercellsthroughinhibitionofNF-kappaBdownstreamregulationofcyclooxygenase-2.CancerInvest,2009,27(1):17-23.
21.Jun-FengLiu,GlynG.Jamieson,PaulA.Drew,Gui-JunZhu,Shao-WeiZhang,Tie-NianZhu,Bao-EnShanQi-ZhangWang.AspirininducesapoptosisinoesophagealcancercellsbyinhibitingthepathwayofNF-kappaBdownstreamregulationofcyclooxygenase-2.ANZJSurg,2005,75(11):1011-1016.
22.Xin-LiHUANG,Yi-QunLING,Tie-NianZHU,Jun-LanZHANG,Yi-LingLING.Multiplefactorscontributingtolipopolysaccharide-inducedreactivitychangesinrabbitpulmonaryartery.ActaPhysiologicaSinica,2005,57(6):737-741.
23.王捷，朱铁年.细丝蛋白A结构与功能的研究进展.临床与病理杂志，2014,34(1):87-92.（通讯作者）
18.张凯，赵瑞景，陈连刚，朱铁年.应用分子靶向治疗的时机选择.医学与哲学,2014,35(1B):46-48.（通讯作者）
24.崔玉洁，张凯，苏同义，朱铁年.乳腺癌分子靶向治疗研究进展.解放军医药杂志,2014，26(1):95-98.(通讯作者)
25.徐陆亭，赵瑞景，董增军，朱铁年.非小细胞肺癌中ROS1基因重排及其临床意义.中国肺癌杂志,2013,16(12):663-670.(通讯作者)
26.陈连刚，张怡梅，刘建坤，朱铁年.吉非替尼治疗晚期肺腺癌脑转移的临床观察.中国肿瘤临床与康复，2011,18(6):529-532.(通讯作者)
27.吴艳萍,李京彬,赵瑞景,王小玲,单保恩,朱铁年.细丝蛋白A在浸润性乳腺癌中的表达及意义.肿瘤，2009,29(7):659-662.(通讯作者)