栗彦宁
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一直进行生物活性小分子基因表达调控与糖尿病及其并发症、肿瘤逆转分化等的分子机制与干预研究。主持国家和省自然科学基金等多项课题研究。发表论文30余篇(SCI论文20余篇,2篇IF5.0,5篇IF3.0以上,其中通讯作者SCI论文4篇)。科研项目:1.国家自然科学基金项目:β-羟丁酸激活claudin-5表达干预糖尿病心脏微血管病变的机制(81600384),17万,主持。2.河北省自然科学基金项目:硝基化激活TGF-β1转录导致糖尿病肾病的分子机制研究(H2012206005),3万元,主持。3.河北省科技支撑计划项目:斑马鱼肿瘤模型建立与组蛋白乙酰化评价(11277160),主持。4.国家自然科学基金项目:β-羟丁酸抗硝基化干预糖尿病心脏微血管病变的机制(81470595),73万,第三主研人。5.国家自然科学基金项目:C-肽调控核因子-kappaB及其共激活因子p300防治糖尿病肾病的分子机制(81070658),33万,第三主研人。6.河北省科学技术成果:基于SLE机制及药物筛选研究的转基因斑马鱼的构建(20133797),第四完成人,2013.12,取得成果证书。近期论文
1.WuXL,MiaoDZ,LiuZJ,LiuK,ZhangBN,LiJL,LiY*,QiJS*,β-hydroxybutyrateantagonizesaorticendothelialinjurybypromotinggenerationofVEGFindiabeticrats,TissueandCell,2020,64,101345.2.JingZhang,RuonanMao,XinyuWang,KunLiu,QiGeng,YijinYu,YanningLi*,JinshengQi*.Targetedinductionofbonemarrowmesenchymalstemcellstohaveeffectivenessondiabeticpancreaticrestoration.InVitroCellDevBiolAnim.2019Jun;55(6):453-461.3.王浩,罗伟刚,栗彦宁*,齐锦生*.β-羟丁酸的保护作用及其机制.生命的化学,2018;38(2):267-272.4.LiY,LiX,HeK,LiB,LiuK,QiJ*,WangH,WangY,LuoW.C-peptidepreventsNF-κBfromrecruitingp300andbindingtotheinospromoterindiabeticnephropathy.FASEBJ.2018;32(4):2269-2279.5.YanningLi,YanZhong,WenjianGong,XuehanGao,HuanliQi,KunLiu,JinshengQi*.C-peptidepreventsSMAD3bindingtoαpromoterstoinhibitcollagentypeIVsynthesis.JMolEndocrinol.2018Jul;61(1):47-56.6.BinLi,YanningLi,KunLiu,XiujuanWang,JinshengQi*,BoyaWang,YuWang.Highglucosedecreasesclaudins-5and-11incardiacmicrovascularendothelialcells:Antagonisticeffectsoftongxinluo.EndocrineResearch.2017;42(1):15-21.7.LiY,ZongY,XiaoZ,ZhuM,XiaoH,QiJ*,LiuK,WangH.DevelopmentalStage-SpecificEmbryonicInductionofHepG2CellDifferentiation.DigDisSci.2016;61(4):1098-106.8.YanningLi,ZhigangXiao,BinLi,KunLiu,HuiWang,JinshengQi*,YuWang.Ginsenosideexhibitsconcentration-dependentdualeffectsonHepG2cellproliferationviaregulationofc-MycandHNF-4α.EurJPharm.2016;792:26-32.9.WangJ,LiY*,XuM,LiD,WangY,QiJ,HeK.Cpeptideexhibitsalateinductioneffectonmatrixmetallopeptidase9inhighglucosestimulatedratmesangialcells.ExpTherMed.2016;12(6):4142-4146.10.LiuK,WangXJ,LiYN,LiB,QiJS*,ZhangJ,WangY.Tongxinluoreversesthehypoxia-suppressedclaudin-9incardiacmicrovascularendothelialcells.ChinMedJ(Engl).2016,129(4):442-447.11.LiYN,WangXJ,LiB,LiuK,QiJS*,LiuBH,TianY.Tongxinluoinhibitscyclooxygenase-2,induciblenitricoxidesynthase,hypoxia-induciblefactor-2α/vascularendothelialgrowthfactortoantagonizeinjuryinhypoxia-stimulatedcardiacmicrovascularendothelialcells.ChinMedJ(Engl).2015;128(8):1114-20.12.LiY,LiuD,ZongY,QiJ*,LiB,LiuK,XiaoH.Developmentalstage-specifichepatocytesinducematurationofHepG2cellsbyrebuildingtheregulatorycircuit.MolMed.2015;21(1):285-95.13.WangX,LiuK,LiB,LiY,YeK,QiJ*,WangY.Macrophagesaggravatehypoxia-inducedcardiacmicrovascularendothelialcellinjuryviaperoxynitrite:protectionbyTongxinluo.CellCommunAdhes.2015;22(2-6):39-47. 相关热点