个人简历

医学博士，教授，博士生导师。河北医科大学心血管医学研究中心主任，河北省医学生物技术重点实验室主任。
近年基金资助情况
1.\t国家自然科学基金重大研究计划-培育项目，50万，2019-1-2021.12，在研，主持
2.\t河北省自然科学基金重点项目，100万,2019.01-2021.12，在研，主持
3.\t国家自然科学基金重大研究计划集成项目，260万，2018.01-2020.12，在研，主持
4.\t国家自然科学基金重大研究计划培育项目，100万元，2015/01-2017/12,已结题，主持；
5.\t国家自然科学基金面上项目，87万元，2015/01-2018/12，已结题，主持；

研究领域

肌动蛋白动力学及其调节蛋白在血管稳态与重构中的作用与调控机制。

近期论文

1.\tDouYQ,KongP,LiCL,SunHX,LiWW,YuY,NieL,ZhaoLL,MiaoSB,LiXK,DongCh,ZhangJW,LiuY,HuoXX,ChiK,GaoX,ZhangN,WengL,YangH,ZhangF,HanM*.SmoothmuscleSIRT1reprogramsendothelialcellstosuppressangiogenesisafterischemia.Theranostics.2020,10:1197-1212.
2.\tKongP，YuY,WangL,DouYQ,ZhangXH,CuiY,WangHY,YongYT,LiuYB,HuHJ,CuiW,SunSG,LiBH,ZhangF,HanM*.circ-Sirt1controlsNF-κBactivationviasequence-specificinteractionandenhancementofSIRT1expressionbybindingtomiR-132/212invascularsmoothmusclecells.NucleicAcidsRes,2019,47:3580-3593.
3.\tMiaoSB,XieXL,YinYJ,ZhaoLL,ZhangF,ShuYN,ChenR,ChenP,DongLH,LinYL,LvP,ZhangDD,NieX,XueZY,HanM*.Accumulationofsmoothmuscle22αproteinacceleratessenescenceofvascularsmoothmusclecellsviastabilizationofp53invitroandinvivo.ArteriosclerThrombVascBiol,2017,37:1849-1859.
4.\tShuYN,DongLH,LiH,PeiQQ,MiaoSB,ZhangF,ZhangDD,ChenR,YinYJ,LinYL,XueZY,LvP,XieXL,ZhaoLL,NieX,ChenP,HanM*.CKII-SIRT1-SM22LoopEvokesaSelf-limitedInflammatoryResponseinVascularSmoothMuscleCells.CardiovascRes,2017,113:1198-1207.
5.\tLvP,ZhangF,YinYJ,WangYC,GaoM,XieXL,ZhaoLL,DongLH,LinYL,ShuYN,ZhangDD,LiuGX,HanM*.SM22αinhibitslamellipodiumformationandmigrationviaRas-Arp2/3signalinginsyntheticVSMCs.AmJPhysiol-CellPhysiol,2016,311:C758-C767.
6.\tZhaoLL,ZhangF,ChenP,XieXL,DouYQ,LinYL,NieL,LvP,ZhangDD,LiXK,MiaoSB,YinYJ,DongLH,SongY,ShuYN,HanM*.Insulin-independentGLUT4translocationinproliferativevascularsmoothmusclecellsinvolvesSM22α.JMolMed（Berl）,2016,95:181-192.
7.\tDongLH,LiL,SongY,DuanZL,SunSG,LinYL,MiaoSB,YinYJ,ShuYN,LiH,ChenP,ZhaoLL,HanM*.TRAF6-mediatedSM22αK21ubiquitinationpromotesG6PDactivationandNADPHproduction,contributingtoGSHhomeostasisandVSMCsurvivalinvitroandinvivo.CircRes.2015,117:684-694.
8.\tShuYN,ZhangF,BiW,DongLH,ZhangDD,ChenR,LvP,XieXL,LinYL,XueZY,LiHB,MiaoSB,ZhaoLL,WangH,HanM*.SM22αinhibitsvascularinflammationviastabilizationofIκBαinvascularsmoothmusclecells.JMolCellCardiol,2015,84:191-199.
9.\tXieXL,NieX,ZhangF,ZhaoLL,LinYL,YinYJ,LiuH,ShuYN,MiaoSB,LiH,ChenP,HanM*.Smoothmuscle22αfacilitatesangiotensinII-inducedsignalingandvascularcontraction,JMolMed（Berl）,2015,93(5):547-58.
10.\tChenR,SongL,ShuYN,LinYL,ZhangF,DongLH,NieX,ZhangD,ChenP,HanM*.TranscriptomeprofilingrevealsanincreasedtendencytodevelopatherosclerosisinSM22α-deficientmice.JMolCellCardiol,2014,72:263-272.
11.\tLvP,MiaoSB,ShuYN,DongLH,LiuG,XieXL,GaoM,WangYC,YinYJ,WangXJ,HanM*.Phosphorylationofsmoothmuscle22αfacilitatesangiotensinII–inducedROSproductionviaactivationofthePKCδ-p47phoxaxisthroughreleaseofPKCδandactindynamicsandisassociatedwithhypertrophyandhyperplasiaofvascularsmoothmusclecellsinvitroandinvivo.CircRes.2012,111:697-707.
12.\tZhangHB,WenJK,ZhangJ,MiaoSB,MaGY,WangYY,ZhengB,HanM*.FlavonoidsfromInulabritannicareducesoxidativestressthroughinhibitingexpressionandphosphorylationofp47phoxinVSMCs.PharmBiology,2011;49(8):815-820.
13.\tDongLH,WenJK,MiaoSB,JiaZ,HuHJ,SunRH,WuY，HanM*.BaicalininhibitsPDGF-BB-stimulatedvascularsmoothmusclecellproliferationthroughsuppressingPDGFRβ-ERKsignalingandincreaseinp27accumulationandpreventsinjury-inducedneointimalhyperplasia.CellRes,2010,20:1252-1262.
14.\tDongLH,WenJK,LiuG,McNuttMA,MiaoSB,GaoR,ZhengB,ZhangH,HanM*.BlockadeofRas-ERK1/2pathwayisinvolvedinSM22α-mediatedsuppressionofVSMCproliferationandneointimahyperplasia.ArteriosclerThrombVascBiol,2010,30:683-691.
受聘CellRes，ArteriosclerThrombVascBiol，NatureCommun，Theranostics等期刊特邀审稿人；以第一或通讯作者在CirculationResearch（IF15.86）,CellResearch（IF17.84）,NucleicAcidsResearch（IF11.14）,Theranostics（IF8.06）,ArteriosclerosisThrombosisandVascularBiology（IF6.61）,CardiovascularResearch（IF7.01）等SCI期刊上发表论文30多篇。任《中国生物化学与分子生物学学报》、《中国细胞生物学学报》、《生命的化学》等期刊编委，中国病理生理学会动脉粥样硬化专业委员会、心血管专业委员会、ISHR中国分会以及ISHR中国转化工作委员会委员,国际动脉粥样硬化学会中国分会理事，河北省生物化学与分子生物学会理事长。